Área Cardiovascular

Endothelial Cell Investigation Unit

Carlos Hermenegildo Caudevilla

Dr. Hermenegildo completed his studies in Medicine and Surgery in the Faculty of Medicine at the University of Valencia where he graduated in 1990; three years later he obtained his doctorate and recognition of his work with the award of the Outstanding Doctoral Thesis Special Prize. 

After a postdoctoral residence at the Institute of Cytological Research in Canada between 2000 and 2008, he became a researcher at the Instituto de Salud Carlos III, first in the Hospital Clínico de Valencia and afterwards at its Research Foundation. In 2008 he was appointed as an Associate Professor and in 2012 he became a permanent Senior Professor in the Physiology Department at the University of Valencia. 

His research focuses on the variations that sex hormones, mainly estrogens, induce in the physiology and physiopathology of the endothelium. Through a genetic and cell biology approach he studies the repercussions of these hormones in menopause, ageing, hypertension, and acute coronary syndrome. He has more than 125 scientific publications and has given in excess of 150 presentations at national and international conferences. He contributes to prestigious international journals and he has directed over 20 doctoral thesis and master’s dissertations. 

He has been the Principal Investigator on 25 projects, attaining competitive public financing over the last 15 years. He is part of the Cardiovascular Research Network (CRN) and is the current Central Research Unit coordinator in the Faculty of Medicine at the University of Valencia (UCIM; Unidad Central de Investigación de la Facultad de Medicina). 

 

•    To identify new endothelial signaling pathways regulated by sex steroid hormones: Analysis of the enzymatic activity of ECA1 and ECA2 in response to the hormone estradiol. 
•    Study of the role of the hormone estradiol in a murine senescence model: Publication of two manuscripts describing the characterization of the model and the participation of endothelial pathways in response to estradiol. 
•    Comparison of the effects of steroid hormones on endothelial cells in relation to the expression levels of estrogen receptors: Starting a differential study to examine the difference between cell samples taken from girls and boys and the impact of these findings on endothelial membrane function. 
•    A functional cell-culture study using human endothelial progenitor cells (EPCs): Publication of the EPC cell culture method and in vitro analysis of their function. Experiments with EPCs from patients with acute myocardial infarction have already been completed.