Área Reproductiva

GI de Células Madre aplicadas a la Reproducción; Viabilidad embrionaria y receptividad endometrial.

Carlos Simón Vallés

El profesor Simón se licenció en Medicina y Cirugía por la Universitat de València en 1985 con Premio Extraordinario de Licenciatura, obteniendo el Doctorado un año después. En la actualidad es Médico Especialista y Catedrático de Obstetricia y Ginecología de esa universidad; Profesor Clínico Adjunto, Departamento de Obstetricia y Ginecología de la Universidad de Stanford, CA. USA y Director Científico del Instituto Valenciano de Infertilidad (IVI). Además es Director Científico y Fundador de IGENOMIX S.L. compañía referente  mundial que ofrece servicios avanzados en genética reproductiva. Ha sido director de 28 Tesis Doctorales todas calificadas con “Sobresaliente Cum Laude”, incluyendo 5 Premios Extraordinarios de Doctorado y 4 Doctorados Europeos.

Desde 1991 ha contribuido con sus trabajos pioneros a la investigación y solución clínica de los problemas que afectan a la receptividad endometrial humana. Utilizando la tecnología de microarrays identificó y cuantificó jerárquicamente los genes implicados en la receptividad endometrial humana. Cuenta con 8 patentes internacionales y 5 nacionales, destacando la relativa a la creación de un array customizado denominado endometrial receptivity array (ERA) para el diagnóstico molecular de la receptividad endometrial en pacientes infértiles. Ha creado un banco de datos de libre acceso (www.endometrialdatabase.com) sobre receptividad endometrial gestionada por la Universitat de València. Ha sido el primero en descubrir las células madre somáticas que aisladas son capaces de reconstruir el endometrio humano.

Es uno de los científicos españoles más prolíficos, un análisis bibliométrico independiente que estudió los trabajos publicados entre 2003 y 2005 en Biología de la Reproducción, identificó al Dr. Simón como el noveno autor más productivo del mundo. Ha publicado un total de 348 trabajos en revistas internacionales peer-review que suman un índice de impacto de 1.541,47 las cuales han recibido 11.139 citas y su índice H es de 60, es editor de 15 libros, siendo “StemCells in Reproductive Medicine” un BestSeller en 2007.

Su impacto científico se ha traducido en múltiples galardones, de prestigiosas entidades Científicas como la Sociedad Española de Fertilidad (SEF); Society for Gynecologic Investigation (SGI); American Society for Reproductive Medicine (ASRM); Serono Symposia International Foundation y European Society of Human Reproduction and Embryology (ESHRE). En 2011 recibió el Premio Rey Jaime I de investigación médica.

 

GI de Células Madre aplicadas a la Reproducción; Viabilidad embrionaria y receptividad endometrial

Investigador colaborador

Alessia Grasso
Amparo Mercader Bayarri
Ana Cristina Cerveró Sanz
Anna Buigues Monfort
Antonio Díez Juan
David Blesa Jarque
Diana Valbuena Perilla
Elena Labarta Demur
Ernesto Bosch Aparicio
Felip Vilella Mitjana
Francisco Domínguez Hernández
Hannes Marcus Campo
Hortensia Ferrero Cháfer
Inmaculada Moreno Gimeno
José Manuel Mínguez Forján
María Herrero Baena
Maria José de los Santos Molina
Nuria López Pérez
Patricia Díaz Gimeno
Silvia Pérez Deben
Stefania Salsano
Xavier Santamaria Costa

Técnico

Alicia Quiñonero Villora
José Bellver Pradas
Mª Amparo Faus Esteve

Investigador predoctoral

Marta Gonzalo Moja
Pilar Alamá Faubel
  • Se ha comprobado la presencia  del marcador Lgr5 y su función biológica en el endometrio humano, este marcador ya descrito como marcador de células madre somáticas en otros tejidos adultos (piel, intestino…) podría tener un papel clave en el endometrio.)
  • Se ha conseguido desarrollar una técnica diagnóstica que determine el momento adecuado de recepción endometrial, desde un punto de vista genómico.
  • Se han identificado dos lípidos específicos que se encuentran presentes en el momento de la adquisición de la receptividad endometrial, son concretamente la prostaglandina E2 (PGE2) y la prostaglandina F2a (PGF2a), se han correlacionado los valores de estos dos lípidos en las pacientes que han quedado embarazadas, comparándolo con las pacientes que no se han quedado embarazadas.
Número total de publicaciones: 184. Factor de Impacto acumulado: 803.06
Preeclampsia: novel insights from global RNA profiling of trophoblast subpopulations.
Gormley M, Ona K, Kapidzic M, Garrido-Gomez T, Zdravkovic T, Fisher SJ.
American journal of obstetrics and gynecology. 2017 Aug. 200. FI: 5.226
Economic impact of ovarian stimulation with corifollitropin alfa versus conventional daily gonadotropins in oocyte donors: a randomized study.
Cruz M, Alamá P, Muñoz M, Collado D, Blanes C, Solbes E, Requena A.
Reproductive biomedicine online. 2017 Mar 14. . FI: 3.249
Why should patients experience infertility or poor outcomes before using assisted reproductive technologies?
Simon C.
Fertility and sterility. 2017 Apr. 878-879. FI: 4.447
Hydrogen Sulfide Improves Cardiomyocyte Function in a Cardiac Arrest Model.
Garcia NA, Moncayo-Arlandi J, Vazquez A, Genovés P, Calvo CJ, Millet J, Martí N, Aguado C, Knecht E, Valiente-Alandi I, Montero JA, Díez-Juan A, Sepúlveda P.
Annals of transplantation. 2017 May 9. 285-295. FI: 1.252
Retraction: Rtt107 Phosphorylation Promotes Localisation to DNA Double-Stranded Breaks (DSBs) and Recombinational Repair between Sister Chromatids
Ullal P, Vilella-Mitjana F, Jarmuz A, Aragón L; PLOS ONE Editors.
PloS one. 2017 Apr 12. e0176035. FI: 2.806
Role of Stro1+/CD44+ stem cells in myometrial physiology and uterine remodeling during pregnancy
Mas A, Prusinski L, Yang Q, Diaz-Gimeno P, Stone L, Diamond MP, Simón C, Al-Hendy A.
Biology of reproduction. 2017 Jan 1. . FI: 3.432
In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study.
Rubio C, Bellver J, Rodrigo L, Castillón G, Guillén A, Vidal C, Giles J, Ferrando M, Cabanillas S, Remohí J, Pellicer A, Simón C.
Fertility and sterility. 2017 Apr 19. . FI: 4.447
Introduction: To transfer or not transfer…a mosaic embryo, that is the question.
Simon C.
Fertility and sterility. 2017 Apr 19. . FI: 4.447
A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of Euploid Embryos.
Labarta E, Bosch E, Mercader A, Alamá P, Mateu E, Pellicer A.
BioMed research international. 2017. 5637923. FI: 2.476
Does an increased body mass index affect endometrial gene expression patterns in infertile patients? A functional genomics analysis.
Comstock IA, Diaz-Gimeno P, Cabanillas S, Bellver J, Sebastian-Leon P, Shah M, Schutt A, Valdes CT, Ruiz-Alonso M, Valbuena D, Simon C, Lathi RB.
Fertility and sterility. 2017 Mar. 740-748.e2. FI: 4.447
Developmental Exposure to Endocrine Disruptors Expands Murine Myometrial Stem Cell Compartment as a Prerequisite to Leiomyoma Tumorigenesis.
Mas A, Stone L, O'Connor PM, Yang Q, Kleven D, Simon C, Walker CL, Al-Hendy A.
Stem cells. 2017 Mar. 666-678. FI: 5.599
Aberrant expression of epithelial leucine-rich repeat containing G protein-coupled receptor 5-positive cells in the eutopic endometrium in endometriosis and implications in deep-infiltrating endometriosis
Vallvé-Juanico J, Suárez-Salvador E, Castellví J, Ballesteros A, Taylor HS, Gil-Moreno A, Santamaria X.
Fertility and sterility. 2017 Nov. . FI: 4.447
Does cumulative live birth plateau beyond a certain ovarian response?
Bosch E, Labarta E, Pellicer A.
Fertility and sterility. 2017 Dec. . FI: 4.447
Implantation failure of endometrial origin: it is not pathology, but our failure to synchronize the developing embryo with a receptive endometrium.
Valdes CT, Schutt A, Simon C.
Fertility and sterility. 2017 Jul. 15-18. FI: 4.447
Endometrial function: facts, urban legends, and an eye to the future.
Valbuena D, Valdes CT, Simon C.
Fertility and sterility. 2017 Jun 7. . FI: 4.447
Corrigendum to "A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of Euploid Embryos"
Labarta E, Bosch E, Mercader A, Alamá P, Mateu E, Pellicer A.
BioMed research international. 2017. . FI: 2.476
Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers
Altmäe S, Koel M, Võsa U, Adler P, Suhorutšenko M, Laisk-Podar T, Kukushkina V, Saare M, Velthut-Meikas A, Krjutškov K, Aghajanova L, Lalitkumar PG, Gemzell-Danielsson K, Giudice L, Simón C, Salumets A.
Scientific reports. 2017 Aug 30. . FI: 4.259
Window of implantation transcriptomic stratification reveals different endometrial subsignatures associated with live birth and biochemical pregnancy
Díaz-Gimeno P, Ruiz-Alonso M, Sebastian-Leon P, Pellicer A, Valbuena D, Simón C.
Fertility and sterility. 2017 Oct. 703-10. FI: 4.447
Dynamic expression of PGRMC1 and SERBP1 in human endometrium: an implication in the human decidualization process
Salsano S, Quiñonero A, Pérez S, Garrido Gómez T, Simón C, Dominguez F
Fertility and sterility. 2017 Nov. 832-842. FI: 4.447
Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology
Garrido-Gomez T, Dominguez F, Quiñonero A, Diaz-Gimeno P, Kapidzic M, Gormley M, Ona K, Padilla-Iserte P, McMaster M, Genbacev O, Perales A, Fisher SJ, Simón C
Proceedings of the National Academy of Sciences of the United States of America. 2017 Oct. E8468-E8477. FI: 9.661
De- and recellularization of the pig uterus: a bioengineering pilot study.
Campo H, Baptista PM, López-Pérez N, Faus A, Cervelló I, Simón C
Biology of reproduction.. 2017 Jan 1. 34-45. FI: 3.471
Lipidomic profiling of endometrial fluid in women with ovarian endometriosis.
Domínguez F, Ferrando M, Díaz-Gimeno P, Quintana F, Fernández G, Castells I, Simón C
Biology of reproduction.. 2017 Mar 18. . FI: 3.471
Leucine-rich repeat-containing G-protein-coupled receptor 5-positive cells in the endometrial stem cell niche.
Cervelló I, Gil-Sanchis C, Santamaría X, Faus A, Vallvé-Juanico J, Díaz-Gimeno P, Genolet O, Pellicer A, Simón C
Fertility and sterility.. 2017 Feb. 510-519.e3. FI: 4.447
A novel homologous model for noninvasive monitoring of endometriosis progression.
Ferrero H, Buigues A, Martínez J, Simón C, Pellicer A, Gómez R
Biology of reproduction.. 2017 Feb 1. 302-312. FI: 3.471
miRNA-1 and miRNA-133a are involved in early commitment of pluripotent stem cells and demonstrate antagonistic roles in the regulation of cardiac differentiation.
Izarra A, Moscoso I, Cañón S, Carreiro C, Fondevila D, Martín-Caballero J, Blanca V, Valiente I, Díez-Juan A, Bernad A.
Journal of tissue engineering and regenerative medicine.. 2017 Mar. 787-799. FI: 3.989
Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion.
Garrido-Gomez T, Ona K, Kapidzic M, Gormley M, Simón C, Genbacev O, Fisher SJ
Development. Supplement.. 2017 Mar 1. 767-777. FI: 6.059
Evidence that the endometrial microbiota has an effect on implantation success or failure.
Moreno I, Codoñer FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazán J, Alonso R, Alamá P, Remohí J, Pellicer A, Ramon D, Simon C
American journal of obstetrics and gynecology.. 2016 Dec. 684-703. FI: 5.226
Detection of Missing Proteins Using the PRIDE Database as a Source of Mass Spectrometry Evidence.
Garin-Muga A, Odriozola L, Martínez-Val A, Del Toro N, Martínez R, Molina M, Cantero L, Rivera R, Garrido N, Dominguez F, Sanchez Del Pino MM, Vizcaíno JA, Corrales FJ, Segura V
Journal of proteome research.. 2016 Nov 4. 4101-4115. FI: 4.173
Bioengineering the uterus: an overview of recent advances and future perspectives in reproductive medicine.
Campo H, Cervelló I, Simón C
Annals of biomedical engineering.. 2016 Dec 27. . FI: 2.887
Integrin α4-positive human trophoblast progenitors: functional characterization and transcriptional regulation.
Genbacev O, Larocque N, Ona K, Prakobphol A, Garrido-Gomez T, Kapidzic M, Bárcena A, Gormley M, Fisher SJ
Human reproduction. 2016 Jun. 1300-14. FI: 5.02
Revised guidelines for good practice in IVF laboratories (2015).
ESHRE Guideline Group on Good Practice in IVF Labs, De los Santos MJ, Apter S, Coticchio G, Debrock S, Lundin K, Plancha CE, Prados F, Rienzi L, Verheyen G, Woodward B, Vermeulen N
Journal of the British Fertility Society.. 2016 Apr. 685-6. FI: 4.621
Aging and the environment affect gamete and embryo potential: can we intervene?
Meldrum DR, Casper RF, Diez-Juan A, Simon C, Domar AD, Frydman R
Fertility and sterility.. 2016 Mar. 548-59. FI: 4.59
Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study.
Santamaria X, Cabanillas S, Cervelló I, Arbona C, Raga F, Ferro J, Palmero J, Remohí J, Pellicer A, Simón C
Human reproduction. 2016 May. 1087-96. FI: 5.02
Both slowly developing embryos and a variable pace of luteal endometrial progression may conspire to prevent normal birth in spite of a capable embryo.
Franasiak JM, Ruiz-Alonso M, Scott RT, Simón C
Fertility and sterility.. 2016 Apr. 861-6. FI: 4.59
Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes.
Garcia NA, Moncayo-Arlandi J, Sepulveda P, Diez-Juan A
Cardiovascular research.. 2016 Mar 1. 397-408. FI: 5.94
Diagnosis of Endometrial-Factor Infertility: Current Approaches and New Avenues for Research.
Katzorke N, Vilella F, Ruiz M, Krüssel JS, Simón C
Geburtshilfe und Frauenheilkunde.. 2016 Jun. 699-703. FI: 0.931
Endometrial 'scratching': what the data show.
Santamaria X, Katzorke N, Simón C
Current opinion in obstetrics & gynecology, with evaluated MEDLINE. 2016 Jun 2. . FI: 2.134
Evaluation of the antiproliferative, proapoptotic, and antiangiogenic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of leiomyoma.
García-Pascual CM, Ferrero H, Juarez I, Martínez J, Villanueva A, Pozuelo-Rubio M, Soengas M, Tormo D, Simón C, Gómez R, Pellicer A
Fertility and sterility.. 2016 Feb. 529-38. FI: 4.59
Human somatic cells subjected to genetic induction with six germ line-related factors display meiotic germ cell-like features.
Medrano JV, Martínez-Arroyo AM, Míguez JM, Moreno I, Martínez S, Quiñonero A, Díaz-Gimeno P, Marqués-Marí AI, Pellicer A, Remohí J, Simón C
Scientific reports.. 2016 Apr 26. 24956. FI: 5.578
Human spermatogonial stem cells display limited proliferation in vitro under mouse spermatogonial stem cell culture conditions.
Medrano JV, Rombaut C, Simon C, Pellicer A, Goossens E
Fertility and sterility.. 2016 Aug 1. . FI: 4.426
Intrauterine human chorionic gonadotropin infusion in oocyte donors promotes endometrial synchrony and induction of early decidual markers for stromal survival: a randomized clinical trial.
Strug MR, Su R, Young JE, Dodds WG, Shavell VI, Díaz-Gimeno P, Ruíz-Alonso M, Simón C, Lessey BA, Leach RE, Fazleabas AT
Journal of the British Fertility Society.. 2016 Apr 26. . FI: 4.569
Molecular disturbance underlies to arrhythmogenic cardiomyopathy induced by transgene content, age and exercise in a truncated PKP2 mouse model.
Moncayo-Arlandi J, Guasch E, Sanz-de la Garza M, Casado M, Garcia NA, Mont L, Sitges M, Knöll R, Buyandelger B, Campuzano O, Diez-Juan A, Brugada R
Human molecular genetics.. 2016 Jul 12. . FI: 5.985
Monitoring Stemness in Long-Term hESC Cultures by Real-Time PCR.
Galán A, Simón C
Photosynthesis research protocols. 2016. 89-104
Morphokinetic analysis and embryonic prediction for blastocyst formation through an integrated time-lapse system.
Motato Y, de Los Santos MJ, Escriba MJ, Ruiz BA, Remohí J, Meseguer M
Fertility and sterility.. 2016 Feb. 376-384.e9. FI: 4.447
ART and uterine pathology: how relevant is the maternal side for implantation?
Galliano D, Bellver J, Díaz-García C, Simón C, Pellicer A
Human reproduction update. 2015 Jan-Feb. 13-38. FI: 10.165
Artificial gametes from stem cells.
Moreno I, Míguez-Forjan JM, Simón C
Clinical and experimental reproductive medicine. 2015 Jun. 33-44
Biomarkers in reproductive medicine: the quest for new answers.
Simon C, Sakkas D, Gardner DK, Critchley HO
Human reproduction update.. 2015 Nov. 695-7. FI: 10.165
Cell therapy and tissue engineering from and toward the uterus.
Cervelló I, Santamaría X, Miyazaki K, Maruyama T, Simón C
Seminars in reproductive medicine.. 2015 Sep. 366-72. FI: 2.352
Circulating miR-200-family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time.
Rekker K, Saare M, Roost AM, Kaart T, Sõritsa D, Karro H, Sõritsa A, Simón C, Salumets A, Peters M
Fertility and sterility.. 2015 Oct. 938-946.e2. FI: 4.59
Congenital malformations, chromosomal abnormalities and perinatal results in IVF/ICSI newborns resulting from very poor quality embryos: a case-control study.
Mendoza R, Perez S, de Los Santos MJ, Larreategui Z, Ayerdi F, Expósito A, Burgos J, Martínez Indart L, Pijoan JI, Matorras R
Gynecologic and obstetric investigation. 2015. 83-9. FI: 1.696
Contribution of different bone marrow-derived cell types in endometrial regeneration using an irradiated murine model.
Gil-Sanchis C, Cervelló I, Khurana S, Faus A, Verfaillie C, Simón C
Fertility and sterility.. 2015 Jun. 1596-605.e1. FI: 4.59
Converting a Problem into an Opportunity: mtDNA Heteroplasmy Shift.
Diez-Juan A, Simón C
Cell stem cell. 2015 May 7. 457-8. FI: 22.268
Day-3 embryo metabolomics in the spent culture media is altered in obese women undergoing in vitro fertilization.
Bellver J, De Los Santos MJ, Alamá P, Castelló D, Privitera L, Galliano D, Labarta E, Vidal C, Pellicer A, Domínguez F
Fertility and sterility. 2015 Jun. 1407-15.e1. FI: 4.59
Dopamine agonist inhibits vascular endothelial growth factor protein production and secretion in granulosa cells.
Ferrero H, García-Pascual CM, Pellicer N, Simón C, Pellicer A, Gómez R
Reproductive biology and endocrinology : RB&E.. 2015 Sep 17. 104. FI: 2.226
Doubtful association between progesterone therapy and fetal nuchal translucency.
Serra V, Bellver J, Garrido N
American journal of obstetrics and gynecology.. 2015 Sep. 437. FI: 4.704
Evaluation of the potential therapeutic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of endometriosis.
García-Pascual CM, Martínez J, Calvo P, Ferrero H, Villanueva A, Pozuelo-Rubio M, Soengas M, Tormo D, Simón C, Pellicer A, Gómez R
Fertility and sterility.. 2015 Nov. 1310-8. FI: 4.59
Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).
Bosch E, Nyboe Andersen A, Barri P, García-Velasco JA, de Sutter P, Fernández-Sánchez M, Visnova H, Klein BM, Mannaerts B, Arce JC
Clinical endocrinology.. 2015 Dec. 902-12. FI: 3.457
Follicular fluid and mural granulosa cells microRNA profiles vary in in vitro fertilization patients depending on their age and oocyte maturation stage.
Moreno JM, Núñez MJ, Quiñonero A, Martínez S, de la Orden M, Simón C, Pellicer A, Díaz-García C, Domínguez F
Fertility and sterility.. 2015 Oct. 1037-1046.e1. FI: 4.59
Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells.
Garcia NA, Ontoria-Oviedo I, González-King H, Diez-Juan A, Sepúlveda P
PLoS hub for clinical trials. 2015. e0138849. FI: 3.234
High responders and patients with a good prognosis are not immune to the negative impact on live birth rate of elevated P on the day of triggering.
Bosch E
Fertility and sterility. 2015 Jun. 1423. FI: 4.59
Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome.
Vilella F, Moreno-Moya JM, Balaguer N, Grasso A, Herrero M, Martínez S, Marcilla A, Simón C
Development. Supplement.. 2015 Sep 15. 3210-21. FI: 6.462
Human CD133(+) bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome.
Cervelló I, Gil-Sanchis C, Santamaría X, Cabanillas S, Díaz A, Faus A, Pellicer A, Simón C
Fertility and sterility.. 2015 Dec. 1552-1560.e3. FI: 4.59
Human Endometrial Transcriptomics: Implications for Embryonic Implantation.
Gómez E, Ruíz-Alonso M, Miravet J, Simón C
Cold Spring Harbor perspectives in medicine. 2015 Mar 27. a022996. FI: 9.468999999999999
Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.
Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent LC, Loring JF, Fisher SJ
Development. Supplement.. 2015 Dec 1. 4010-25. FI: 6.462
Is endometrial receptivity transcriptomics affected in women with endometriosis? A pilot study.
Garcia-Velasco JA, Fassbender A, Ruiz-Alonso M, Blesa D, D'Hooghe T, Simon C
Reproductive biomedicine online.. 2015 Nov. 647-54. FI: 3.015
Mir-661: A key Factor in Embryo-Maternal dialog With Potential Clinical Application to Predict Implantation Outcome?
Cano A, Gomez R
EBioMedicine.. 2015 Oct. 1312-3
Mitochondrial DNA content as a viability score in human euploid embryos: less is better.
Diez-Juan A, Rubio C, Marin C, Martinez S, Al-Asmar N, Riboldi M, Díaz-Gimeno P, Valbuena D, Simón C
Fertility and sterility.. 2015 Sep. 534-41.e1. FI: 4.59
Molecular analysis of products of conception obtained by hysteroembryoscopy from infertile couples.
Campos-Galindo I, García-Herrero S, Martínez-Conejero JA, Ferro J, Simón C, Rubio C
Journal of assisted reproduction and genetics. 2015 May. 839-48. FI: 1.718
New strategy for diagnosing embryo implantation potential by combining proteomics and time-lapse technologies.
Dominguez F, Meseguer M, Aparicio-Ruiz B, Piqueras P, Quiñonero A, Simón C
Fertility and sterility.. 2015 Oct. 908-14. FI: 4.59
Ovary transplantation: to activate or not to activate.
Kawamura K, Cheng Y, Sun YP, Zhai J, Diaz-Garcia C, Simon C, Pellicer A, Hsueh AJ
Journal of the British Fertility Society.. 2015 Nov. 2457-60. FI: 4.569
Overexpression of the truncated form of High Mobility Group A proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation.
Mas A, Cervelló I, Fernández-Álvarez A, Faus A, Díaz A, Burgués O, Casado M, Simón C
Molecular human reproduction. 2015 Apr. 330-8. FI: 3.747
Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis.
Vera-Rodriguez M, Chavez SL, Rubio C, Pera RA, Simon C
Nature communications. 2015 Jul 7. 7601. FI: 11.47
Prospective study into the value of the automated Elecsys antimüllerian hormone assay for the assessment of the ovarian growing follicle pool.
Anderson RA, Anckaert E, Bosch E, Dewailly D, Dunlop CE, Fehr D, Nardo L, Smitz J, Tremellen K, Denk B, Geistanger A, Hund M
Fertility and sterility. 2015 Apr. 1074-1080.e4. FI: 4.59
Soluble ligands and their receptors in human embryo development and implantation.
Thouas GA, Dominguez F, Green MP, Vilella F, Simon C, Gardner DK
Endocrine reviews. 2015 Feb. 92-130. FI: 21.059
Stem cells in reproductive medicine: ready for the patient?
Vassena R, Eguizabal C, Heindryckx B, Sermon K, Simon C, van Pelt AM, Veiga A, Zambelli F, ESHRE special interest group Stem Cells
Journal of the British Fertility Society.. 2015 Sep. 2014-21. FI: 4.569
Stro-1/CD44 as putative human myometrial and fibroid stem cell markers.
Mas A, Nair S, Laknaur A, Simón C, Diamond MP, Al-Hendy A
Fertility and sterility.. 2015 Jul. 225-34.e3. FI: 4.59
The educational and professional status of clinical embryology and clinical embryologists in Europe†.
Kova?i? B, Plas C, Woodward BJ, Verheyen G, Prados FJ, Hreinsson J, De Los Santos MJ, Magli MC, Lundin K, Plancha CE
Human reproduction (Oxford, England). 2015 Aug. 1755-62. FI: 4.569
The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies.
Martínez-Varea A, Pellicer B, Serra V, Hervás-Marín D, Martínez-Romero A, Bellver J, Perales-Marín A, Pellicer A
Journal of immunology research.. 2015. 128616
The Metabolomic Profile of Spent Culture Media from Day-3 Human Embryos Cultured under Low Oxygen Tension.
de Los Santos MJ, Gámiz P, de Los Santos JM, Romero JL, Prados N, Alonso C, Remohí J, Dominguez F
PLoS hub for clinical trials. 2015. e0142724. FI: 3.234
The necessity to define the sub-optimal responders.
Garcia-Velasco JA, Bosch E
Journal of the British Fertility Society.. 2015 Dec. 2958. FI: 4.569
The time to prevent mendelian genetic diseases from donated or own gametes has come.
Garrido N, Bosch E, Alamá P, Ruiz A
Fertility and sterility.. 2015 Oct. 833-5. FI: 4.59
Trends in clinical reproductive medicine research: 10 years of growth.
Aleixandre-Benavent R, Simon C, Fauser BC
Fertility and sterility.. 2015 Jul. 131-7.e5. FI: 4.59
Understanding and improving endometrial receptivity.
Miravet-Valenciano JA, Rincon-Bertolin A, Vilella F, Simon C
Current opinion in obstetrics & gynecology, with evaluated MEDLINE. 2015 Jun. 187-92. FI: 2.067
Understanding Mammalian Germ Line Development with In Vitro Models.
Martínez-Arroyo AM, Míguez-Forján JM, Remohí J, Pellicer A, Medrano JV
Stem cells and development.. 2015 Sep 15. 2101-13. FI: 3.727
A multicenter prospective study to assess the effect of early cleavage on embryo quality, implantation, and live-birth rate.
de Los Santos MJ, Arroyo G, Busquet A, Calderón G, Cuadros J, Hurtado de Mendoza MV, Moragas M, Herrer R, Ortiz A, Pons C, Ten J, Vilches MA, Figueroa MJ, ASEBIR Interest Group in Embryology
Fertility and sterility. 2014 Apr. 981-7. FI: 4.295
Angiogenic growth factors in maternal and fetal serum in concordant and discordant twin pregnancies.
Ruiz-Sacedón N, Perales-Puchalt A, Borras D, Gómez R, Perales A
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2014 Jun. 870-3. FI: 1.208
BACs-on-Beads technology: a reliable test for rapid detection of aneuploidies and microdeletions in prenatal diagnosis.
García-Herrero S, Campos-Galindo I, Martínez-Conejero JA, Serra V, Olmo I, Lara C, Simón C, Rubio C
BioMed research international. 2014. 590298
Clinical management of endometrial receptivity.
Blesa D, Ruiz-Alonso M, Simón C
Seminars in reproductive medicine. 2014 Sep. 410-4. FI: 3
Clinical validation of embryo culture and selection by morphokinetic analysis: a randomized, controlled trial of the EmbryoScope.
Rubio I, Galán A, Larreategui Z, Ayerdi F, Bellver J, Herrero J, Meseguer M
Fertility and sterility. 2014 Nov. 1287-1294.e5. FI: 4.59
Comment on 'Recombinant LH supplementation to a standard GnRH antagonist protocol in women of 35 years old or older undergoing IVF/ICSI: a randomized controlled multicentre study'.
Bosch E
Human reproduction (Oxford, England). 2014 Mar. 636-7. FI: 4.585
Complete method to obtain, culture, and transfer mouse blastocysts nonsurgically to study implantation and development.
Moreno-Moya JM, Ramírez L, Vilella F, Martínez S, Quiñonero A, Noguera I, Pellicer A, Simón C
Fertility and sterility. 2014 Mar. e13. FI: 4.59
Current understanding of somatic stem cells in leiomyoma formation.
Mas A, Cervello I, Gil-Sanchis C, Simón C
Fertility and sterility. 2014 Sep. 613-620. FI: 4.59
Deciphering the proteomic signature of human endometrial receptivity.
Garrido-Gómez T, Quiñonero A, Antúnez O, Díaz-Gimeno P, Bellver J, Simón C, Domínguez F
Human reproduction (Oxford, England). 2014 Sep. 1957-67. FI: 4.569
Does progesterone elevation compromise pregnancy rates in high responders? Insufficient evidence to draw a conclusion.
Bosch E
Fertility and sterility. 2014 Jan. e3-4. FI: 4.295
Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in an ovarian hyperstimulation syndrome (OHSS) animal model: implications for treatment of OHSS with dopamine receptor 2 agonists.
Ferrero H, García-Pascual CM, Gaytán M, Morales C, Simón C, Gaytán F, Pellicer A, Gómez R
Fertility and sterility. 2014 Nov. 1468-1476.e1. FI: 4.295
Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in vitro: implications for treatment of ovarian hyperstimulation syndrome with dopamine receptor 2 agonists.
Ferrero H, García-Pascual CM, Gómez R, Delgado-Rosas F, Cauli O, Simón C, Gaytán F, Pellicer A
Fertility and sterility. 2014 May. 1411-1418.e2. FI: 4.295
Embryonic miRNA profiles of normal and ectopic pregnancies.
Dominguez F, Moreno-Moya JM, Lozoya T, Romero A, Martínez S, Monterde M, Gurrea M, Ferri B, Núñez MJ, Simón C, Pellicer A
PloS one. 2014. e102185. FI: 3.234
Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment.
Court F, Tayama C, Romanelli V, Martin-Trujillo A, Iglesias-Platas I, Okamura K, Sugahara N, Simón C, Moore H, Harness JV, Keirstead H, Sanchez-Mut JV, Kaneki E, Lapunzina P, Soejima H, Wake N, Esteller M, Ogata T, Hata K, Nakabayashi K, Monk D
Genome research. 2014 Apr. 554-69. FI: 13.852
Germ cell transplantation into mouse testes procedure.
Medrano JV, Martínez-Arroyo AM, Sukhwani M, Noguera I, Quiñonero A, Martínez-Jabaloyas JM, Pellicer A, Remohí J, Orwig KE, Simón C
Fertility and sterility. 2014 Oct. e11-2. FI: 4.295
Germ line development: lessons learned from pluripotent stem cells.
Martínez-Arroyo AM, Medrano JV, Remohí J, Simón C
Current opinion in genetics & development. 2014 Oct. 64-70. FI: 8.568
Guidelines for the design, analysis and interpretation of 'omics' data: focus on human endometrium.
Altmäe S, Esteban FJ, Stavreus-Evers A, Simón C, Giudice L, Lessey BA, Horcajadas JA, Macklon NS, D'Hooghe T, Campoy C, Fauser BC, Salamonsen LA, Salumets A
Human reproduction update. 2014 Jan-Feb. 47088. FI: 8.657
High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study.
Requena A, Cruz M, Bosch E, Meseguer M, García-Velasco JA
Reproductive biology and endocrinology : RB&E. 2014 Jul 26. 69. FI: 2.226
Human germ cell differentiation from pluripotent embryonic stem cells and induced pluripotent stem cells.
Medrano JV, Simon C, Pera RR
Methods in molecular biology (Clifton, N.J.). 2014. 563-78
Impact of final oocyte maturation using gonadotropin-releasing hormone agonist triggering and different luteal support protocols on endometrial gene expression.
Bermejo A, Cerrillo M, Ruiz-Alonso M, Blesa D, Simón C, Pellicer A, Garcia-Velasco JA
Fertility and sterility. 2014 Jan. 138-146.e3. FI: 4.295
Impact of ovarian stimulation with gonadotrophins on embryo aneuploidy.
Labarta E, Bosch E, Pellicer A
Human reproduction update. 2014 Nov-Dec. 964. FI: 8.657
Inhibition of Delta-like 4 mediated signaling induces abortion in mice due to deregulation of decidual angiogenesis.
García-Pascual CM, Ferrero H, Zimmermann RC, Simón C, Pellicer A, Gómez R
Placenta. 2014 Jul. 501-8. FI: 3.285
Introduction: Are we advancing in our scientific understanding and therapeutic improvement of uterine fibroids… or not?
Simón C
Fertility and sterility. 2014 Sep. 611-2. FI: 4.295
Is ovarian reserve related to blood type?
Bellver J
Fertility and sterility. 2014 Dec. 1563-4. FI: 4.295
ISGE statement on oral emergency contraception.
Glasier A, Gemzell-Danielsson K, Bouchard P, Genazzani AR, Al-Azzawi F, Berga S, Birkhaeuser M, Brincat M, De Melo NR, Foidart JM, Kenemans P, Lunenfeld B, Maruo T, Milewicz A, Naftolin F, Ng EH, Schindler A, Simon C, Simoncini T, Simpson E, Siseles N, Smetnik V, Tarlatzis B, von Schoultz B
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2014 Oct. 681-2. FI: 1.136
Live birth after embryo transfer in an unresponsive thin endometrium.
Cruz F, Bellver J
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2014 Jul. 481-4. FI: 1.136
MicroRNA and gynecological reproductive diseases.
Santamaria X, Taylor H
Fertility and sterility. 2014 Jun. 1545-51. FI: 4.295
MicroRNA: key gene expression regulators.
Moreno-Moya JM, Vilella F, Simón C
Fertility and sterility. 2014 Jun. 1516-1523. FI: 4.59
New tools for embryo selection: comprehensive chromosome screening by array comparative genomic hybridization.
Rodrigo L, Mateu E, Mercader A, Cobo AC, Peinado V, Milán M, Al-Asmar N, Campos-Galindo I, García-Herrero S, Mir P, Simón C, Rubio C
BioMed research international. 2014. 517125
Ovarian response to recombinant human follicle-stimulating hormone: a randomized, antimüllerian hormone-stratified, dose-response trial in women undergoing in vitro fertilization/intracytoplasmic sperm injection.
Arce JC, Nyboe Andersen A, Fernández-Sánchez M, Visnova H, Bosch E, García-Velasco JA, Barri P, de Sutter P, Klein BM, Fauser BC
Fertility and sterility. 2014 Dec. 1633-1640.e5. FI: 4.295
Reply of the authors.
de Los Santos MJ
Fertility and sterility. 2014 May. e35. FI: 4.295
Reply of the authors.
Bellver J, Serra V
Fertility and sterility. 2014 Mar. e19. FI: 4.295
Reply: Endometrial scratching for women with repeated implantation failure.
Simón C, Bosch E, Bellver J
Human reproduction (Oxford, England). 2014 Dec. 2856-7. FI: 4.585
Scratching beneath 'The Scratching Case': systematic reviews and meta-analyses, the back door for evidence-based medicine.
Simón C, Bellver J
Human reproduction (Oxford, England). 2014 Aug. 1618-21. FI: 4.585
The impact of using the combined oral contraceptive pill for cycle scheduling on gene expression related to endometrial receptivity.
Bermejo A, Iglesias C, Ruiz-Alonso M, Blesa D, Simón C, Pellicer A, García-Velasco J
Human reproduction (Oxford, England). 2014 Jun. 1271-8. FI: 4.585
The Lin28/Let-7 system in early human embryonic tissue and ectopic pregnancy.
Lozoya T, Domínguez F, Romero-Ruiz A, Steffani L, Martínez S, Monterde M, Ferri B, Núñez MJ, AinhoaRomero-Espinós, Zamora O, Gurrea M, Sangiao-Alvarellos S, Vega O, Simón C, Pellicer A, Tena-Sempere M
PloS one. 2014. e87698. FI: 3.234
The transcriptomic and proteomic effects of ectopic overexpression of miR-30d in human endometrial epithelial cells.
Moreno-Moya JM, Vilella F, Martínez S, Pellicer A, Simón C
Molecular human reproduction. 2014 Jun. 550-66. FI: 3.747
Timing the window of implantation by nucleolar channel system prevalence matches the accuracy of the endometrial receptivity array.
Nejat EJ, Ruiz-Alonso M, Simón C, Meier UT
Fertility and sterility. 2014 Nov. 1477-81. FI: 4.295
Transcriptomics of the human endometrium.
Díaz-Gimeno P, Ruíz-Alonso M, Blesa D, Simón C
The International journal of developmental biology. 2014. 127-37. FI: 2.567
Variable maternal methylation overlapping the nc886/vtRNA2-1 locus is locked between hypermethylated repeats and is frequently altered in cancer.
Romanelli V, Nakabayashi K, Vizoso M, Moran S, Iglesias-Platas I, Sugahara N, Simón C, Hata K, Esteller M, Court F, Monk D
Epigenetics. 2014 May. 783-90. FI: 5.108
What a difference two days make: "personalized" embryo transfer (pET) paradigm: a case report and pilot study.
Ruiz-Alonso M, Galindo N, Pellicer A, Simón C
Human reproduction (Oxford, England). 2014 Jun. 1244-7. FI: 4.585
A "double hit" murine model for schizophrenia shows alterations in the structure and neurochemistry of the medial prefrontal cortex and the hippocampus.
Gilabert-Juan J, Belles M, Saez AR, Carceller H, Zamarbide-Fores S, Moltó MD, Nacher J
Neurobiology of disease. 2013 Nov. 126-40. FI: 5.624
A time to look back: analysis of morphokinetic characteristics of human embryo development.
Herrero J, Tejera A, Albert C, Vidal C, de los Santos MJ, Meseguer M
Fertility and sterility. 2013 Dec. 1602-9.e1-4. FI: 4.295
Acadesine for patients with relapsed/refractory chronic lymphocytic leukemia (CLL): a multicenter phase I/II study.
Van Den Neste E, Cazin B, Janssens A, González-Barca E, Terol MJ, Levy V, Pérez de Oteyza J, Zachee P, Saunders A, de Frias M, Campàs C
Cancer chemotherapy and pharmacology. 2013 Mar. 581-91. FI: 2.795
Age-associated telomere shortening in mouse oocytes.
Yamada-Fukunaga T, Yamada M, Hamatani T, Chikazawa N, Ogawa S, Akutsu H, Miura T, Miyado K, Tarín JJ, Kuji N, Umezawa A, Yoshimura Y
Reproductive biology and endocrinology : RB&E. 2013 Nov 21. 108. FI: 2.144
Are physicians underestimating the challenges of hypertension management? Results from the Supporting Hypertension Awareness and Research Europe-wide (SHARE) survey.
Erdine S, Redon J, Böhm M, Ferri C, Kolloch R, Kreutz R, Laurent S, Persu A, Schmieder RE, SHARE Steering Committee
European journal of preventive cardiology. 2013 Oct. 786-92
Cells expressing markers of immature neurons in the amygdala of adult humans.
Martí-Mengual U, Varea E, Crespo C, Blasco-Ibáñez JM, Nacher J
The European journal of neuroscience. 2013 Jan. 44835. FI: 3.753
Cells, stem cells, and cancer stem cells.
Aguilar-Gallardo C, Simón C
Seminars in reproductive medicine. 2013 Jan. 41395. FI: 3.211
Defining the genomic signature of totipotency and pluripotency during early human development.
Galan A, Diaz-Gimeno P, Poo ME, Valbuena D, Sanchez E, Ruiz V, Dopazo J, Montaner D, Conesa A, Simon C
PloS one. 2013. e62135. FI: 3.73
Effect of vitrification on human oocytes: a metabolic profiling study.
Dominguez F, Castello D, Remohí J, Simón C, Cobo A
Fertility and sterility. 2013 Feb. 565-572.e3. FI: 4.174
Gene expression in amygdala as a function of differential trait anxiety levels in genetically heterogeneous NIH-HS rats.
Díaz-Morán S, Palència M, Mont-Cardona C, Cañete T, Blázquez G, Martínez-Membrives E, López-Aumatell R, Sabariego M, Donaire R, Morón I, Torres C, Martínez-Conejero JA, Tobeña A, Esteban FJ, Fernández-Teruel A
Behavioural brain research. 2013 Sep 1. 422-31. FI: 3.327
Gene expression in hippocampus as a function of differential trait anxiety levels in genetically heterogeneous NIH-HS rats.
Díaz-Morán S, Palència M, Mont-Cardona C, Cañete T, Blázquez G, Martínez-Membrives E, López-Aumatell R, Sabariego M, Donaire R, Morón I, Torres C, Martínez-Conejero JA, Tobeña A, Esteban FJ, Fernández-Teruel A
Behavioural brain research. 2013 Oct 1. 129-139. FI: 3.327
Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy.
Palomares AR, Lendínez-Ramírez AM, Pérez-Nevot B, Cortés-Rodríguez M, Martínez F, Garrido N, Ruiz-Galdón M, Reyes-Engel A
Fertility and sterility. 2013 Jun. 2009-2016.e2. FI: 4.295
Germ cell differentiation from pluripotent cells.
Medrano JV, Pera RA, Simón C
Seminars in reproductive medicine. 2013 Jan. 14-23. FI: 3.211
Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) as a putative human endometrial stem cell marker.
Gil-Sanchis C, Cervelló I, Mas A, Faus A, Pellicer A, Simón C
Molecular human reproduction. 2013 Jul. 407-14. FI: 3.483
Incidence and predictors of ovarian function recovery (OFR) in breast cancer (BC) patients with chemotherapy-induced amenorrhea (CIA) who switched from tamoxifen to exemestane.
Guerrero A, Gavilá J, Folkerd E, Ortiz B, Martínez F, García A, Climent MA, Guillem V, Ruíz A
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2013 Mar. 674-9. FI: 7.384
Lipidomics as an emerging tool to predict endometrial receptivity.
Vilella F, Ramirez LB, Simón C
Fertility and sterility. 2013 Mar 15. 1100-6. FI: 4.295
New insights in aneuploidy screening: old principles, new approaches.
Rubio C
Fertility and sterility. 2013 Sep. 652-3. FI: 4.174
Outcome of cryotransfer of embryos developed from vitrified oocytes: double vitrification has no impact on delivery rates.
Cobo A, Castellò D, Vallejo B, Albert C, de Los Santos JM, Remohí J
Fertility and sterility. 2013 May. 1623-1630.e7. FI: 4.174
Periorbital necrobiosis lipoidica.
Pitarch G, Giner F
Actas dermo-sifiliográficas. 2013 Sep. 636-8
Preface. Biomarkers in reproductive medicine.
Simón C, Barnhart K
Fertility and sterility. 2013 Mar 15. 953. FI: 4.174
Profiling the gene signature of endometrial receptivity: clinical results.
Garrido-Gómez T, Ruiz-Alonso M, Blesa D, Diaz-Gimeno P, Vilella F, Simón C
Fertility and sterility. 2013 Mar 15. 1078-85. FI: 4.295
Protocols for tracking and witnessing samples and patients in assisted reproductive technology.
de los Santos MJ, Ruiz A
Fertility and sterility. 2013 Dec. 1499-502. FI: 4.174
Response to lenalidomide in myelodysplastic syndromes with del(5q): influence of cytogenetics and mutations.
Mallo M, Del Rey M, Ibáñez M, Calasanz MJ, Arenillas L, Larráyoz MJ, Pedro C, Jerez A, Maciejewski J, Costa D, Nomdedeu M, Diez-Campelo M, Lumbreras E, González-Martínez T, Marugán I, Such E, Cervera J, Cigudosa JC, Alvarez S, Florensa L, Hernández JM, Solé F
British journal of haematology. 2013 Jul. 74-86. FI: 4.942
Somatic stem cells in the human endometrium.
Cervelló I, Mas A, Gil-Sanchis C, Simón C
Seminars in reproductive medicine. 2013 Jan. 69-76. FI: 3
Stem cells helping reproductive medicine.
Simón C
Seminars in reproductive medicine. 2013 Jan. 41732. FI: 3.211
The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.
Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, Gómez E, Fernández-Sánchez M, Carranza F, Carrera J, Vilella F, Pellicer A, Simón C
Fertility and sterility. 2013 Sep. 818-24. FI: 4.295
The impact of next-generation sequencing technology on preimplantation genetic diagnosis and screening.
Martín J, Cervero A, Mir P, Conejero Martinez JA, Pellicer A, Simón C
Fertility and sterility. 2013 Mar 15. 1054-61.e3. FI: 4.174
Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivo effects on migration capacity and tumor growth.
Belmar-Lopez C, Mendoza G, Oberg D, Burnet J, Simon C, Cervello I, Iglesias M, Ramirez JC, Lopez-Larrubia P, Quintanilla M, Martin-Duque P
BMC medicine. 2013 May 28. 139. FI: 7.276
Transobturator suburethral tape in the treatment of stress urinary incontinence: Efficacy and quality of life after 5 year follow up.
Cañete P, Ortiz E, Domingo S, Cano A
Maturitas. 2013 Feb. 166-71. FI: 2.844
Vascular disrupting and antiangiogenic agents: better together than on their own.
Gómez R
Fertility and sterility. 2013 Nov. 1234-5. FI: 4.174
PGE2 and PGF2? Concentrations in Human Endometrial Fluid as Biomarkers for Embryonic Implantation.
Vilella F, Ramirez L, Berlanga O, Martínez S, Alamá P, Meseguer M, Pellicer A, Simón C
The Journal of clinical endocrinology and metabolism. 2013 Oct. 4123-32. FI: 6.31
A novel model of human implantation: 3D endometrium-like culture system to study attachment of human trophoblast (Jar) cell spheroids.
Wang H, Pilla F, Anderson S, Martínez-Escribano S, Herrer I, Moreno-Moya JM, Musti S, Bocca S, Oehninger S, Horcajadas JA
Molecular human reproduction. 2012 Jan. 33-43. FI: 4.542
Annexin A2 is critical for embryo adhesiveness to the human endometrium by RhoA activation through F-actin regulation.
Garrido-Gómez T, Dominguez F, Quiñonero A, Estella C, Vilella F, Pellicer A, Simon C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 Sep. 3715-27. FI: 5.704
Bone marrow-derived cells from male donors do not contribute to the endometrial side population of the recipient.
Cervelló I, Gil-Sanchis C, Mas A, Faus A, Sanz J, Moscardó F, Higueras G, Sanz MA, Pellicer A, Simón C
PloS one. 2012. e30260. FI: 3.73
Can we skip weekends in GnRH antagonist cycles without compromising the final outcome?
Bosch E
Fertility and sterility. 2012 Jun. 1299-300. FI: 4.174
Chromosomal abnormalities in embryos from couples with a previous aneuploid miscarriage.
Al-Asmar N, Peinado V, Vera M, Remohí J, Pellicer A, Simón C, Hassold T, Rubio C
Fertility and sterility. 2012 Jul. 145-50. FI: 4.174
Cleavage of endometrial ?-integrins into their functional forms is mediated by proprotein convertase 5/6.
Paule S, Aljofan M, Simon C, Rombauts LJ, Nie G
Human reproduction (Oxford, England). 2012 Sep. 2766-74. FI: 4.67
Comparison of Cryotip vs. Cryotop for mouse and human blastomere vitrification.
Valbuena D, Póo ME, Aguilar-Gallardo C, Martinez S, Cobo AC, Pellicer A, Simón C
Fertility and sterility. 2012 Jan. 209-17. FI: 4.174
Differential metabolic profiling of non-pure trisomy 21 human preimplantation embryos.
Sánchez-Ribas I, Riqueros M, Vime P, Puchades-Carrasco L, Jönsson T, Pineda-Lucena A, Ballesteros A, Domínguez F, Simón C
Fertility and sterility. 2012 Nov. 1157-1164.e2. FI: 4.174
Divergent RNA-binding proteins, DAZL and VASA, induce meiotic progression in human germ cells derived in vitro.
Medrano JV, Ramathal C, Nguyen HN, Simon C, Reijo Pera RA
Stem cells (Dayton, Ohio). 2012 Mar. 441-51. FI: 7.701
Efficiency and purity provided by the existing methods for the isolation of luteinized granulosa cells: a comparative study.
Ferrero H, Delgado-Rosas F, Garcia-Pascual CM, Monterde M, Zimmermann RC, Simón C, Pellicer A, Gómez R
Human reproduction (Oxford, England). 2012 Jun. 1781-9. FI: 4.67
Follicular and endocrine profiles associated with different GnRH-antagonist regimens: a randomized controlled trial.
García-Velasco JA, Kupesic S, Pellicer A, Bourgain C, Simón C, Mrazek M, Devroey P, Arce JC
Reproductive biomedicine online. 2012 Feb. 153-62. FI: 2.675
Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation.
Evans GE, Martínez-Conejero JA, Phillipson GT, Simón C, McNoe LA, Sykes PH, Horcajadas JA, Lam EY, Print CG, Sin IL, Evans JJ
Fertility and sterility. 2012 Jun. 1365-73.e1-2. FI: 4.174
Hormonal and molecular characterization of follicular fluid, cumulus cells and oocytes from pre-ovulatory follicles in stimulated and unstimulated cycles.
de los Santos MJ, García-Láez V, Beltrán-Torregrosa D, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Pellicer A, Labarta E
Human reproduction (Oxford, England). 2012 Jun. 1596-605. FI: 4.67
Human embryonic stem cells derived in xeno-free conditions.
Galán A, Simón C
Methods in molecular biology (Clifton, N.J.). 2012. 13-32
Human pre-implantation embryo development.
Niakan KK, Han J, Pedersen RA, Simon C, Pera RA
Development (Cambridge, England). 2012 Mar. 829-41. FI: 6.208
Identification and characterization of the human leiomyoma side population as putative tumor-initiating cells.
Mas A, Cervelló I, Gil-Sanchis C, Faus A, Ferro J, Pellicer A, Simón C
Fertility and sterility. 2012 Sep. 741-751.e6. FI: 4.174
In vitro production of haploid cells after coculture of CD49f+ with Sertoli cells from testicular sperm extraction in nonobstructive azoospermic patients.
Riboldi M, Rubio C, Pellicer A, Gil-Salom M, Simón C
Fertility and sterility. 2012 Sep. 580-590.e4. FI: 4.174
Inhibition of histone deacetylase activity in human endometrial stromal cells promotes extracellular matrix remodelling and limits embryo invasion.
Estella C, Herrer I, Atkinson SP, Quiñonero A, Martínez S, Pellicer A, Simón C
PloS one. 2012. e30508. FI: 3.73
Migration of cells from experimental endometriosis to the uterine endometrium.
Santamaria X, Massasa EE, Taylor HS
Endocrinology. 2012 Nov. 5566-74. FI: 4.717
miRNA Signature and Dicer Requirement during Human Endometrial Stromal Decidualization In Vitro.
Estella C, Herrer I, Moreno-Moya JM, Quiñonero A, Martínez S, Pellicer A, Simón C
PloS one. 2012. e41080. FI: 3.73
Moderate ovarian stimulation does not increase the incidence of human embryo chromosomal abnormalities in in vitro fertilization cycles.
Labarta E, Bosch E, Alamá P, Rubio C, Rodrigo L, Pellicer A
The Journal of clinical endocrinology and metabolism. 2012 Oct. E1987-94. FI: 6.43
Outcomes of vitrified early cleavage-stage and blastocyst-stage embryos in a cryopreservation program: evaluation of 3,150 warming cycles.
Cobo A, de Los Santos MJ, Castellò D, Gámiz P, Campos P, Remohí J
Fertility and sterility. 2012 Nov. 1138-1146.e1. FI: 4.174
Overcoming challenges of ovarian cancer stem cells: novel therapeutic approaches.
Aguilar-Gallardo C, Rutledge EC, Martínez-Arroyo AM, Hidalgo JJ, Domingo S, Simón C
Stem cell reviews. 2012 Sep. 994-1010. FI: 4.523
Somatic stem cells and tissue engineering shed light on unsolved clinical issues in reproductive medicine: in stem cells we trust.
Simón C
Fertility and sterility. 2012 Jul. 41671. FI: 4.174
The dynamics of in vitro maturation of germinal vesicle oocytes.
Escrich L, Grau N, de los Santos MJ, Romero JL, Pellicer A, Escribá MJ
Fertility and sterility. 2012 Nov. 1147-51. FI: 4.174
The genomics of the human endometrium.
Ruiz-Alonso M, Blesa D, Simón C
Biochimica et biophysica acta. 2012 Dec. 1931-42
The Role of LH in Ovarian Stimulation.
Munoz E, Bosch E, Fernandez I, Portela S, Ortiz G, Remohi J, Pellicer A
Current pharmaceutical biotechnology. 2012 Mar 1. 409-16. FI: 2.69
Viral screening of spent culture media and liquid nitrogen samples of oocytes and embryos from hepatitis B, hepatitis C, and human immunodeficiency virus chronically infected women undergoing in vitro fertilization cycles.
Cobo A, Bellver J, de Los Santos MJ, Remohí J
Fertility and sterility. 2012 Jan. 74-8. FI: 4.174

Herramienta para el Diagnóstico Precoz de Preeclampsia basado en el fallo de decidualización endometrial que se manifiesta en el embarazo de mujeres.

Referencia:
GV/2016/033
Investigador principal:
Tamara Garrido Gomez
Entidad financiadora:
Conselleria de Educación, Cultura y Deporte
Duración:
01/01/2016 - 31/12/2018
Presupuesto total:
€16.000

Estudio de los miRNAs secretados al líquido endometrial y su papel en la regulación del embrión en los primeros estadios de desarrollo.

Referencia:
PI14/00545
Investigador principal:
Felip Vilella Mitjana
Entidad financiadora:
Instituto de Salud Carlos III
Duración:
01/01/2015 - 31/12/2017
Presupuesto total:
€81.500

Desarrollo de una herramienta diagnóstica de fallo de implantación. Descripción del perfil proteómico y definición del interactoma del fallo de implantación.

Referencia:
CP13/00076
Investigador principal:
Francisco Domínguez Hernández
Entidad financiadora:
Instituto de Salud Carlos III
Duración:
01/01/2014 - 31/12/2016
Presupuesto total:
€121.450

Herramienta de diagnóstico para predecir obesidad y diabetes de tipo 2 en la descendencia. Papel de los miRNAs maternos en la transmisión de la obesidad y la diabetes de tipo 2 al embrión.

Referencia:
GV/2014/136
Investigador principal:
Felip Vilella Mitjana
Entidad financiadora:
Conselleria de Educación, Cultura y Deporte
Duración:
01/01/2014 - 31/12/2014
Presupuesto total:
€6.000

Descripción del perfil proteómico endometrial del Fallo de Implantación recurrente. Creación del interactoma del fallo de implantación

Referencia:
ACOMP/2014/004
Investigador principal:
Francisco Domínguez Hernández
Entidad financiadora:
Conselleria de Educación, Cultura y Deporte
Duración:
01/01/2014 - 31/12/2014
Presupuesto total:
€10.900

Descripción del perfil proteómico endometrial del Fallo de Implantación recurrente. Creación del interactoma del fallo de implantación.

Referencia:
PI12/00450
Investigador principal:
Francisco Domínguez Hernández
Entidad financiadora:
Instituto de Salud Carlos III
Duración:
01/01/2013 - 31/12/2015
Presupuesto total:
€29.645

Implicación del marcador Lgr5 en la generación endotelial en modelos animales.

Referencia:
Convocatoria 2012 de ayudas intramurales para grupos emergentes
Investigador principal:
Irene Cervelló Alcaraz
Entidad financiadora:
Fundación Investigación Hospital Clínico Universitario de Valencia
Duración:
01/01/2013 - 31/12/2014
Presupuesto total:
€8.500

Aislamiento y caracterización de células madre endometriales lgr5+. Reconstrucción del endometrio humano a través de xenotrasplante en un modelo de ratón NOD-SCID.

Referencia:
GV/2013/120
Investigador principal:
Irene Cervelló Alcaraz
Entidad financiadora:
Conselleria de Educación, Cultura y Deporte
Duración:
01/01/2013 - 31/12/2014
Presupuesto total:
€6.000

INCLIVA, aliado de investigación para las empresas del Patronato de ADEIT

Reunión entre ADEIT e INCLIVA para buscar sinergias.

Publicado el 19/04/2018.Leer más »

Un año más, los investigadores de INCLIVA entre los mejores investigadores de Valencia

Según el ranking basado en el factor h elaborado por DIH, el Dr. Carlos Simón el segundo en el ranking de su especialidad en España.

Publicado el 11/01/2017.Leer más »

Un estudio científico relaciona por primera vez la baja presencia de lactobacilos en el útero con un peor pronóstico reproductivo

Un equipo de investigadores de INCLIVA y de las empresas Igenomix, Biopolis y Lifesequencing acaban de publicar, en American Journal of Obstetrics and Gynecology, un estudio que relaciona por primera vez la baja presencia de Lactobacillus en el útero con un peor pronóstico reproductivo. El estudio confirma una vez más la importancia del endometrio ante la gestación y abre la puerta a un análisis previo de la flora del útero en pacientes con dificultades reproductivas.

Publicado el 08/12/2016.Leer más »

Carlos Simón, primer europeo en ser galardonado por la Sociedad Americana de Medicina Reproductiva por su trayectoria investigadora

Solo doce investigadores de reproducción humana, de todo el mundo, han conseguido el ASRM Distinguished Researcher Award. Carlos Simón es el primer europeo que ostenta este galardón.

Publicado el 18/10/2016.Leer más »

INCLIVA y el IVI investigarán la influencia de la madre obesa y/o fumadora en el perfil genético de su bebe durante la gestación

Se estudiará la influencia epigenética de la gestante fumadora y si influye en la genética del feto dejar de fumar. 

Publicado el 06/06/2016.Leer más »