Detection and Control of Ventricular Dysfunction

Objectives

– Electrical remodeling: experimental studies on the protective effect against the arrhythmic vulnerability of modifications of the signaling pathways
– Ventricular remodeling: evaluation of the role of microvascular damage, prediction of postinfarction clinical evolution
– Biomarkers: clinical studies aimed at the validation of biomarkers related to the degradation of components of the extra-cellular matrix

Research Lines

– Characterization of the direct electrophysiological effects of the active metabolite of sacubitril
– Study of the modifications of the electrophysiological effects of overload sharp mechanics
– Analysis of the protective effects produced by chronic treatment with inhibitors
– Mechanisms involved in the deterioration of systolic function, fibrosis and the inducibility of arrhythmias
– Development of useful working instruments in the study of cardiac electrophysiology
– Basic research related to ischemia and myocardial infarction
– Prospective and multicenter registry (Hospital Clínico Universitario de Valencia and Hospital Clínic de Barcelona and Hospital Vall d’Hebrón de Barcelona) of patients
– Prognostic value of geriatric conditions in older patients admitted for acute coronary syndrome