Research Group on Maternal Fetal Communication
Reproductive Medicine Area
Project origin of diseases: functional capacity of miRNAs secreted into endometrial fluid in obese and type 2 diabetic patients to determine if they are capable of modifying mouse embryos transcriptomically and/or epigeneticallyProject Transcriptomic and epigenetic modifications in human embryos: obtain the target genes of miRNA miR-30d in human embryos to have a list of regions potentially susceptible to methylation. These regions will be used to design the PCRs of the bisulfite regions by miSeq sequencing
Project Function of DNA and RNA contained in extracellular vesicles secreted by the human endometrium on the pre-implantation embryo: it has been described that the endometrial fluid is secreted by a series of populations of extracellular vesicles (apoptotic bodies, microvesicles and exosomes) that represent a conveyance. We propose that these vesicles contain biomolecules of different natures, specifically focusing on the different types of RNAs and DNA, and that their composition in these chemical species varies throughout the menstrual cycle and depending on the subpopulation of vesicles that is analyzed
Coordinator
STAFF
Collaborating Researchers
Nurse
Technicians
Ana Ochando HernándezSofía Zaragozano MartínezAnna Quirant Pellín
Administrative assistant
Publications
The human periconceptional maternal-embryonic space in health and disease. Moreno I, Capalbo A, Mas A, Garrido-Gomez T, Roson B, Poli M, Dimitriadis E, Santamaria X, Vilella F, Simon C. Physiological Reviews. 2023 Jul 1;103(3):1965-2038. doi: 10.1152/physrev.00050.2021. PMID: 36796099
The role of extracellular vesicles in intercellular communication in human reproduction. Gonzalez Fernandez J, Moncayo Arlandi J, Ochando A, Simon C, Vilella F. Clinical Science. 2023 Feb 14;137(3):281-301. doi: 10.1042/CS20220793. PMID: 36762584
Vertical transmission of maternal DNA through extracellular vesicles associates with altered embryo bioenergetics during the periconception period. Bolumar D, Moncayo-Arlandi J, Gonzalez-Fernandez J, Ochando A, Moreno I, Monteagudo-Sanchez A, Marin C, Diez A, Fabra P, Checa M, Espinos J, Gardner D, Simon C, Vilella F. eLife. 2023 Dec 27:12:RP88008. doi: 10.7554/eLife.88008. PMID: 38149847
Understanding the human endometrium in the 21st century. Vilella F, Wang W, Moreno I, Quake SR, Simon C. American Journal of Obstetrics and Gynecology. 2021 Jul;225(1):1-2. doi: 10.1016/j.ajog.2021.04.224. PMID: 34023092
Projects
Title: Caracterización transcriptómica de la implantación embrionaria humana a nivel de célula única usando un endometrio 3D en un chip de microfluidica
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Vilella Mitjana
Duration: 2022 – 2024
Total budget: 90.750 €
Title: Human Uterus Cell Atlas
Funding body: European Commission
Principal Investigator: Carlos Simón Vallés
Duration: 2020 – 2022
Total budget: 4.118.943 €
Title: Función del ADN y ARN contenido en vesiculas extracelulares secretadas por el endometrio humano sobre el embrion pre-implantatorio
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felip Vilella Mitjana
Duration: 2019 – 2022
Total budget: 135.520 €
+ Info
Doctoral candidate: Bolumar Recuero, David
Director(s): Simón Vallés, Carlos; Vilella Mitjana, Felipe
Date of the defense: 21/12/2020
University: Universitat de València
Title: Epigenetic analysis of cell-free dna as a tool to study pathogenesis and maternal syndrome of preeclampsia
Doctoral candidate: Corachán García, Irene
Director(s): Simón Vallés, Carlos; Díez Juan, Antonio; Vilella Mitjana, Felipe
Date of the defense: 14/02/2020
University: Universitat de València
Title: Maternal-fetal crosstalk. Elucitaing the role of mir30d in endometrial receptivity and pregnancy outcome
Doctoral candidate: Balaguer Cuenca, Nuria
Director(s): Vilella Mitjana, Felipe; Simón Vallés, Carlos
Date of the defense: 14/01/2019
University: Universitat de València