Research Group on Molecular Microbiology and Microbial Pathogenesis
Oncology Area
Study of the basic aspects of infectious diseases
Study of the microorganisms that cause human pathology, characterization, biology and physiopathogenesis
The implementation and optimization of the use of new diagnostic technologies in the clinical management of infectious patients, particularly in the context of a basic onco-haematological pathology
Creation of multidisciplinary “diagnostic stewardship” Units (Programs for optimization of the use of diagnostic techniques -PRODIM-) with other services (Oncology/Hematology/ICU/Resuscitation, Primary Care)
Study of the immunobiology of patients with infectious diseases, characterization and study of their clinical impact on individuals and society
Coordinator
RESEARCHERS
Established, R3
Jesús Rodríguez Díaz
First Stage, R1
Ángela Sánchez SimarroCristina Santiso BellónJosé María Ferrer ChirivellaNazaret Peña GilRoberto Cárcamo Calvo
STAFF
Collaborating Researchers
Javier Colomina RodríguezMª Ángeles Clarí PonsSergi López Navarro
Nurse
Technicians
Ester Colomer RoigPatricia Navarro Domínguez
Administrative assistant
Publications
Emergence of cefiderocol resistance during ceftazidime/avibactam treatment caused by a large genomic deletion, including ampD and piuCD genes, in Pseudomonas aeruginosa. Gomis-Font M, Clari M, Lopez-Causapé C, Navarro D, Oliver A. Antimicrobial Agents and Chemotherapy. 2024 Jan 10;68(1):e0119223. doi: 10.1128/aac.01192-23. PMID: 38063398
A rapid MALDI-TOF mass spectrometry-based method for categorization of Pseudomonas aeruginosa from blood cultures as susceptible or resistant to meropenem. Sanchez D, Torres I, Gimenez E, Albert E, Costa R, Padron C, Carretero D, Colomina J, Navarro D. Journal of Microbiological Methods. 2023 Aug 6;212:106803. doi: 10.1016/j.mimet.2023.106803. PMID: 37544430
American Society of Transplantation and Cellular Therapy Series: #7-Management of Respiratory Syncytial Virus Infections in Hematopoietic Cell Transplant Recipients. El Chaer F, Kaul D, Englund J, Boeckh M, Batista M, Seo S, Carpenter P, Navarro D, Hirsch H, Ison M, Papanicolaou G, Chemaly R. Transplantation and Cellular Therapy. 2023 Dec;29(12):730-738. doi: 10.1016/j.jtct.2023.09.018. PMID: 37783338
Assessment of the potential value of plasma Torque Teno virus DNA load monitoring to predict cytomegalovirus DNAemia in patients with hematological malignancies treated with small molecule inhibitors: a proof-of-concept study. de la Asunción C, Giménez E, Hernández-Boluda J, Terol M, Albert E, López J, García-Gutiérrez V, Andreu R, Malo M, Fox M, Remigia M, Amat P, Solano C, Navarro D. Journal of Medical Virology. 2023 Jul;95(7):e28933. doi: 10.1002/jmv.28933. PMID: 37403897
Culture of human rotaviruses in relevant models shows differences in culture-adapted and nonculture-adapted strains. Peña-Gil N, Randazzo W, Carmona-Vicente N, Santiso-Bellón C, Carcamo-Cálvo R, Navarro-Lleó N, Monedero V, Yebra M, Buesa J, Gozalbo-Rovira R, Rodríguez-Díaz J. International Journal of Molecular Sciences. 2023 Dec 11;24(24):17362. doi: 10.3390/ijms242417362. PMID: 38139191
Applicability of probabilistic graphical models for early detection of SARS-CoV-2 reactive antibodies after SARS-CoV-2 vaccination in hematological patients. Pinana J, Rodriguez-Belenguer P, Caballero D, Martino R, Lopez-Corral L, Terol M, Vazquez L, Calabuig M, Sanz-Linares G, Marin-Jimenez F, Alonso C, Montoro J, Ferrer E, Facal A, Pascual M, Rodriguez-Fernandez A, Olave M, Cascales-Hernandez A, Gago B, Hernandez-Rivas J, Villalon L, Corona M, Roldan-Perez A, Ribes-Amoros J, Gonzalez-Santillana C, Garcia-Sanz R, Navarro D, Serrano-Lopez A, Cedillo A, Soria-Olivas E, Sureda A, Solano C. Annals of Hematology. 2022 Sep;101(9):2053-2067. doi: 10.1007/s00277-022-04906-8. PMID: 35780254
BD MAX enteric bacterial, bacterial plus, and virus panels for diagnosis of acute infectious gastroenteritis: a cost-benefit analysis. Ferrer J, Gimenez E, Carretero D, Buesa J, Morillas F, Granell R, Fuenmayor A, Navarro D, Albert E. Microbiology Spectrum. 2022 Oct 26;10(5):e0088022. doi: 10.1128/spectrum.00880-22. PMID: 36069590
Booster effect after SARS-CoV-2 vaccination in immunocompromised hematology patients with prior COVID-19. Piñana JL, Garcia-Sanz R, Martino R, Garcia-Roa M, Martin-Martin GA, Risco-Gálvez I, Tormo M, Martinez-Barranco P, Marcos-Corrales S, Calabuig M, Conesa V, Teruel A, Ruiz-Pérez S, Solano C, Navarro D, Cedillo Á, Sureda A. Blood Advances. 2022 Jan 8;6(3):848-853. doi: 10.1182/bloodadvances.2021006326. PMID: 34905620
CAPA in progress: a new real-life approach for the management of critically ill COVID-19 patients. Carbonell N, Alcaraz M, Serrano-Lazaro A, Rodriguez-Gimillo M, Ramos D, Ros F, Ferrer J, Blasco M, Navarro D, Clari M. Biomedicines. 2022 Jul 13;10(7):1683. doi: 10.3390/biomedicines10071683. PMID: 35884988
Amplification of human beta-glucoronidase gene for appraising the accuracy of negative SARS-CoV-2 RT-PCR results in upper respiratory tract specimens. Albert Vicent E, Ferrer Lores B, Torres Fink I, Serrano Alcalá A, Alcaráz Soriana M, Buesa Gomez J, Solano Vercet C, Colomina Rodríguez F, Bueno Ferrando F, Huntley Pascual D, Olea Miguel B, Valdivia Piqueres A, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):48-50. doi: 10.1002/jmv.26112. PMID: 32484950
Assessing the potential association between SARS-CoV-2 RNA load in the respiratory tract and COVID-19 mortality. Albert E, Bracho M, Serrano A, Ferrer B, Gonzalez-Candelas F, Navarro D. Journal of Medical Virology. 2021 Apr;93(4):1862-1864. doi: 10.1002/jmv.26644. PMID: 33135804
Bacterial metabolites trimethylamine N-oxide and butyrate as surrogates of small intestinal bacterial overgrowth in patients with a recent decompensated heart failure. Mollar A, Marrachelli V, Nunez E, Monleon D, Bodi V, Sanchis J, Navarro D, Nunez J. Scientific reports. 2021 Mar 17;11(1):6110. doi: 10.1038/s41598-021-85527-5. PMID: 33731747
Caveats in interpreting SARS-CoV-2 IgM positive/IgG negative antibody profile in asymptomatic health care workers.. Valdivia Piqueres A, Torres Fink I, Huntley Pascual D, Alcaráz Soriana M, Albert Vicent E, Solano De La Asunción C, González Padrón C, Ferrer Dot J, Navarro Ortega D. Journal of Medical Virology. 2021 Feb;93(2):634-636. doi: 10.1002/jmv.26400. PMID: 32761912
Projects
Title: Role of host mucosal glycosylation in SARS-CoV-2 infectivity
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Jesús Rodríguez Díaz
Duration: 2022 – 2024
Total budget: 90.000 €
Title: Inmunidad adaptativa de linfocitos B y T frente a SARS-CoV-2 tras la vacunación de pacientes en riesgo de sufrir COVID-19 severa
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: David Navarro Ortega, Estela Giménez
Duration: 2022 – 2024
Total budget: 169.400 €
Title: Personalisation of immunosuppression by monitoring viral load post kidney transplantation – a randomised controlled phase II trial
Funding body: European Commission
Principal Investigator: David Navarro Ortega
Duration: 2021 – 2026
Total budget: 85.625 €
Title: Glicosil hidrolasas bacterianas y su función en la infectividad viral
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Jesús Rodríguez Díaz
Duration: 2021 – 2024
Total budget: 160.930 €
Title: TECO: Validación de dos sistemas biosensor para la diagnosis simultánea de covid19 y otros patógenos aéreos
Funding body: Universidad de Valencia – INCLIVA
Principal Investigator: David Giménez Romero, Estela Giménez Quiles
Duration: 2021 – 2022
Total budget: 19.000 €
Title: Virología e inmunología de la infección por el citomegalovirus (CMV) en el paciente con neoplasia hematológicas en la era de las nuevas bioterapias
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: David Navarro Ortega
Duration: 2019 – 2022
Total budget: 111.320 €
Title: Inmunobiología de la infección por el citomegalovirus en el trasplante alogénico de precursores hematopoyéticos haploidéntico asociado al uso de ciclofosfamida postrasplante
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: David Navarro Ortega
Duration: 2016 – 2019
Total budget: 98.615 €
+ Info
Guidelines for the management of cytomegalovirus infection in patients with haematological malignancies and after stem cell transplantation from the 2017 European Conference on Infections in Leukaemia (ECIL 7). Ljungman P, de la Camara R, Robin C, Crocchiolo R, Einsele H, Hill JA6, Hubacek P7, Navarro D8, Cordonnier C3, Ward KN9; 2017 European Conference on Infections in Leukaemia group. LANCET INFECTIOUS DISEASES. 2019 Aug; 19(8): e260-e272. doi: 10.1016/S1473-3099(19)30107-0. PMID: 31153807
Doctoral candidate: Torres Fink, Ignacio
Director(s): Navarro Ortega, David
Date of the defense: 14/07/2022
University: Universitat de València
Title: Valor predictivo de la carga viral de citomegalovirus y torquetenovirus en heces y plasma del desarrollo de la enfermedad injerto contra huésped intestinal en pacientes sometidos a trasplante alogénico de precursores hematopoyéticos
Doctoral candidate: Bueno Ferrando, Felipe
Director(s): Navarro Ortega, David
Date of the defense: 15/06/2022
University: Universitat de València
Title: Factores predictivos de desarrollo y evolución de infección activa por citomegalovirus en el trasplante alogénico de precursores hematopoyéticos
Doctoral candidate: Vinuesa Velasco, Víctor
Director(s): Navarro Ortega, David
Date of the defense: 08/09/2021
University: Universitat de València
Title: Parámetros biológicos predictivos de la infección activa precoz por Citomegalovirus en el trasplante alogénico de precursores hematopoyéticos
Doctoral candidate: Talaya Peñalver, Alberto
Director(s): Navarro Ortega, David
Date of the defense: 26/05/2021
University: Universitat de València
Title: Desarrollo de un dispositivo médico tipo “point of care” para la detección rápida de infección urinaria y sensibilidad antibiótica en países en vías de desarrollo
Doctoral candidate: Jover García, Jorge
Director(s): Colomina Rodríguez, Javier
Date of the defense: 12/03/2021
University: Universitat de València
Title: Vigilancia de la susceptibilidad antibiótica y caracterización genotípica de aislados de Neisseria Gonorrhoeae en la Comunidad Valenciana: proyecto multicéntrico GONOvig
Doctoral candidate: Fabregat Bolufer, Aleix Borja
Director(s): Colomina Rodríguez, Javier
Date of the defense: 26/02/2021
University: Universitat de València
Title: Torque teno virus como marcador subrogado de inmunocompetencia en el trasplante
Doctoral candidate: Albert Vicent, Eliseo
Director(s): Navarro Ortega, David
Date of the defense: 13/02/2020
University: Universitat de València
Title: Concentración mínima inhibitoria de vancomicina para staphylococcus aureus y riesgo de bacteriemia complicada
Doctoral candidate: Falcón Abad, Rocío
Director(s): Navarro Ortega, David
Date of the defense: 02/10/2019
University: Universitat de València