Research Group on General and Digestive Surgery
Metabolism and Organic Damage Area
The General and Digestive Surgery Group is an extensive research group that is working on various aspects of General and Digestive Surgery. It is made up of different Units (Colorectal, Hepatobiliopancreatic, Esophagogastric and peritoneal carcinomatosis surgery, Endocrine-Metabolic, Breast, and Abdominal Wall). All of them are very active, developing different lines of research, in accordance with the objectives of each Unit, leading to multiple publications annually, many of them multicenter, focused mainly on oncological, endocrine-metabolic and process management aspects.
Coordinator
RESEARCHERS
Established, R3
Alejandro Espí Macías
Recognised/Emerging, R2
David Casado RodrigoDavid Moro ValdezateDimitri DorcarattoElena Muñoz FornerEstefanía García BotelloFernando López MozosJosé Martín ArévaloMª Carmen Fernández MorenoMarina Garcés AlbirNorberto Cassinello FernándezRaquel Alfonso BallesterVicente Pla Martí
First Stage, R1
Leticia Pérez SantiagoCarlos León EspinozaIsabel Mora OliverMaría Lapeña Rodríguez
STAFF
Collaborating Researchers
Elena Martí CuñatGuillermo Pou SantonjaMª Eugenia Barrios CarvajalMarcos Adrianzén VargasRosa Martí FernándezVicente López Flor
Nurse
Margarita Fernández GuardiolaVictoria Alejandra López Callejón
Technicians
Administrative assistant
Publications
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries. ESCP EAGLE Safe Anastomosis Collaborative and NIHR Global Health Research Unit in Surgery. British Journal of Surgery. 2024 Jan 3;111(1):znad370. doi: 10.1093/bjs/znad370. PMID: 38029386
Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID). Rojas-Holguín A, Fondevila-Campo C, Sanjuanbenito A, Fabregat-Prous J, Secanella-Medayo L, Rotellar-Sastre F, Pardo-Sánchez F, Prieto-Calvo M, Marín-Ortega H, Sánchez-Cabús S, Diez-Valladares L, Alonso-Casado Ó, González-Serrano C, Rodríguez-Sanjuan JC, García-Plaza G, Jaén-Torrejimeno I, Suárez-Muñoz MÁ, Becerra-Massare A, Rio PS, Pando E, López-Andújar R, Muñoz-Forner E, Rodriguez-López M, Pereira F, Serrablo-Requejo A, Turrión VS, Garrido MJ, Burdío F, Martín-Pérez E, Estevan-Estevan R, López-Guerra D, Castell-Gómez J, Salinas-Gómez J, López-Baena JÁ, López-Ben S, Solar-García L, Pérez-Alonso AJ, Martínez-Insfran LA, Blas JL, Cornejo M, Gutierrez-Calvo A, Pozo CD, Ochando-Cerdan F, Muñoz-Bellvís L, Rebollar-Saenz J, Sánchez B, Jover JM, Gómez-Bravo MÁ, Ramia JM, Blanco-Fernández G. Surgical Oncology-Oxford. 2024 Feb:52:102039. doi: 10.1016/j.suronc.2024.102039. PMID: 38301449
Solid pseudopapillary neoplasms of the pancreas: multicenter Vasepa study. Alvarez X, Fernando Alcazar C, Hernando Sanz A, Mora Oliver I, Granel L, Barreras J, Calero A, Carbonell Morote S, Domingo C, Estevan R, Oliver I, Lopez Andujar R, Sabater L, Compan A, Ramia J. Cirugia Espanola. 2024 Feb 12:S2173-5077(24)00047-4. doi: 10.1016/j.cireng.2024.02.001. PMID: 38355041
With COVID-19 came the change and expansion of MAS programs in breast pathology. Buch E, Bauza M, Munoz E, Adrianzen M, Lopez V. Cirugia Espanola. 2024 Jan 13:S2173-5077(24)00019-X. doi: 10.1016/j.cireng.2023.07.009. PMID: 38224765
An unusual case of proctalgia: kerosene rectal injury. Benitez Riesco A, Perez Santiago L, Puente Monserrat J, Moro Valdezate D. Revista Espanola de Enfermedades Digestivas. 2023 Nov 30. doi: 10.17235/reed.2023.10098/2023. PMID: 38031923
CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction. Hueso L, Marques P, Morant B, Gonzalez-Navarro H, Ortega J, Real J, Sanz M, Piqueras L. Frontiers in Endocrinology. 2023 Apr 12;14:1154158. doi: 10.3389/fendo.2023.1154158. PMID: 37124725
Characteristics of gastrointestinal stromal tumors associated to other tumors. Marti-Obiol R, Marti-Fernandez R, Fernandez-Moreno M, Barrios-Carvajal M, Lopez-Mozos F. Cirugia Espanola. 2023 Dec 20:S2173-5077(23)00252-1. doi: 10.1016/j.cireng.2023.11.014. PMID: 38135151
Clinical and cost outcomes of a polyethylene glycol (PEG)-coated patch versus drainage after axillary lymph node dissection in breast cancer: results from a multicentre randomized clinical trial. Buch-Villa E, Castaner-Puga C, Delgado-Garcia S, Fuster-Diana C, Vidal-Herrador B, Ripoll-Orts F, Galeote-Quecedo T, Prat A, Andres-Matias M, Jimeno-Fraile J, Munoz-Sorsona E, Vento G, Gumbau-Puchol V, Adrianzen M, Lopez-Flor V, Ortega J. British Journal of Surgery. 2023 Aug 11;110(9):1180-1188. doi: 10.1093/bjs/znad150. PMID: 37311694
ASO visual abstract: long-term outcomes of perioperative versus neoadjuvant chemotherapy for resectable colorectal liver metastases-an international multicenter propensity-score matched analysis with stratification by contemporary risk scoring. Di Martino M, Primavesi F, Syn N, Dorcaratto D, de la Hoz Rodriguez A, Dupre A, Piardi T, Rhaiem R, Blanco Fernandez G, de Armas Conde N, Rodriguez Sanjuan J, Fernandez Santiago R, Fernandez-Moreno M, Ferret G, Lopez Ben S, Suarez Munoz M, Perez-Alonso A, Koh Y, Jones R, Martin-Perez E. Annals of Surgical Oncology. 2022 Oct;29(11):6845-6846. doi: 10.1245/s10434-022-12077-z. PMID: 35810229
Concordance and survival implications of preoperative subclassification of T3 rectal cancers by depth of mesorectal invasion using a 5-mm cut-off point with endorectal ultrasound and magnetic resonance imaging. Botello S, Fernandez R, Lozano C, Salher S, Arevalo J, Valdezate D, Marti V, Macias A. Quantitative Imaging in Medicine and Surgery. 2022 Apr;12(4):2356-2367. doi: 10.21037/qims-21-880. PMID: 35371947
Dr. Luis Aparisi Quereda In memoriam. Sabater L, Sastre J, de Madaria E. Gastroenterologia y Hepatologia. 2022 Oct 12:S0210-5705(22)00218-7. doi: 10.1016/j.gastrohep.2022.08.011. PMID: 36243628
Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries. NIHR Global Health Unit on Global Surgery; COVIDSurg Collaborative. Lancet. 2022 Nov 5;400(10363):1607-1617. doi: 10.1016/S0140-6736(22)01846-3. PMID: 36328042
Botulinum toxin injection plus topical diltiazem for chronic anal fissure: a randomized double-blind clinical trial and long-term outcome. Herreros B, Espi A, Monton Rodriguez C, Garcia-Granero E, Sanchiz V, Ferriols FL, Almela P, Hernandez V, Mora F, Minguez M. Diseases of the Colon and Rectum. 2021 Dec 1;64(12):1521-1530. doi: 10.1097/DCR.0000000000001983. PMID: 34747917
Circulating Tumor DNA Detection by Digital-Droplet PCR in Pancreatic Ductal Adenocarcinoma: A Systematic Review. Huerta M, Rosello S, Sabater L, Ferrer A, Tarazona N, Roda D, Gambardella V, Alfaro-Cervello C, Garces-Albir M, Cervantes A, Ibarrola-Villava M. Cancers. 2021 Feb 27;13(5):994. doi: 10.3390/cancers13050994. PMID: 33673558
Clinical symptoms are correlated with gastrojejunal anastomosis complications only during the first year after laparoscopic Roux-en-Y gastric bypass. Lapena Rodriguez M, Cassinello Fernandez N, Martin Arevalo J, Sanchiz Soler V, Alfonso Ballester R, Ortega Serrano J. Nutricion Hospitalaria. 2021 Oct 13;38(5):978-982. doi: 10.20960/nh.03602. PMID: 34036791
Corrigendum to Corrigendum to Hydroxyethyl starch and acute kidney injury in high-risk patients undergoing cardiac surgery: A prospective multicenter study [J Clin Anesth 2021 Oct;73:110367]. Nagore D, Candela A, Burge M, Monedero P, Tamayo E, Alvarez J, Murie M, Wijeysundera DN, Vives M, Vives M, Mendez E, Pasqualetto A, Mon T, Pita R, Varela MA, Esteva C, Pereira MA, Sanchez J, Rodriguez MA, Garcia A, Carmona P, Lopez M, Pajares A, Vicente R, Aparicio R, Gragera I, Calderon E, Candela A, Marcos JM, Gomez L, Rodriguez JM, Matilla A, Medina A, Morales L, Santana L, Garcia E, Monedero P, Montesinos S, Munoz P, Bravo B, Alvarez J, Blanco V. Journal of Clinical Anesthesia. 2021 Dec;75:110436. doi: 10.1016/j.jclinane.2021.110436. PMID: 34509966
Projects
Title: Transección Pancreática asistida por Radiofrecuencia vs Endograpadora. TRANSPAIRE. Ensayo clínico en fase III
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Patricia Sánchez Velázquez
Duration: 2021 – 2023
Total budget: 75.020 €
Title: Anastomosis pancreática tras duodenopancreatect omía cefálica: pancreatogastrostomia versus anastomosis de blumgart. estudio prospectivo, aleatorizado y multicéntrico
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Luis Sabater Ortí
Duration: 2020 – 2024
Total budget: 85.910 €
Title: Impacto de la diseminación de las CTCs durante la duodenopancreatectomía cefálica en la aparición de metástasis y supervivencia en pacientes con tumores de páncreas y periampulares
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Javier Padillo
Duration: 2017 – 2019
Total budget: 80.465 €
Title: Duodenopancreatectomía cefálica en tumores de páncreas y periampulares: abordaje inicial de la arteria mesentérica superior versus abordaje clásico. Estudio prospectivo, aleatorizado y multicéntrico
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Luis Sabater Ortí
Duration: 2016 – 2019
Total budget: 56.265 €
+ Info
Doctoral candidate: Fernández Moreno, María Del Carmen
Director(s): Ortega Serrano, Joaquín; López Mozos, Fernando; Martí Obiol, Roberto
Date of the defense: 30/06/2023
University: University de Valencia
Title: Estándares de calidad en el tratamiento de la carcinomatosis peritoneal de origen colorectal mediante citorreducción y quimioterapia intraperitoneal hipertermia (HIPEC)
Doctoral candidate: García Fadrique, Alfonso Luis
Director(s): Sabater Ortí, Luis; Estevan Estevan, Rafael; Escrig Sos, Javier
Date of the defense: 18/12/2020
University: Universitat de València