Research Group on Epigenomics and Translational Epigenetics

Metabolism and Organic Damage Area

Our research is focused on elucidating the importance of redox control of post-translational histone modifications and the intricate control of epigenetic mechanisms by oxidative stress. Specifically, our research is aimed to elucidate how oxidative stress and inflammation drive the dysregulation of epigenetic mechanisms, which in turn contribute to diseases (Free Rad. Biol. Med. 2010, 2012, 2013, 2015, 2017, 2021).Moreover, we are looking for potential epigenetic biomarkers which can improve precision medicine in sepsis. Particularly, we are investigating how extracellular histones contributes to tissue damage and organ dysfunction during sepsis, as well as the potential of extracellular histones to become diagnostic and prognostic biomarkers for sepsis and septic shock. In addition, DNA methylation and microRNAs are analyzed by EPIC850K methylation arrays and smallRNA-seq to further clarify the immune response dysregulation and immunosuppression in septic patients.

Generation of 3D biomodels (i.e. spheroids and organoids) as models to study organ damage in sepsis.

Research on the epigenetic mechanisms related with inflammation and immunosuppression.

Working group in EpiENoD strategy to create the first reference methylome of Spanish population.

Dr. Jose Luis García Giménez
Coordinator
Dr. Jose Luis García Giménez
j.luis.garcia@uv.es

RESEARCHERS
Leading, R4
Established, R3

Salvador Mena Mollá
Nieves Carbonell Monleón
Jose Luis García Giménez    

Recognised/Emerging, R2

Marta Seco Cervera

First Stage, R1

María Rodríguez Gimillo
Irene Cánovas Cervera
Elena Nácher Sendra
Beatriz Quevedo Sánchez

STAFF
Collaborating Researchers
Nurse
Technicians

Rosa Calpe Fortea
Enric Dolz Andrés
Elena Climent Martínez

Administrative assistant
Publications
Alterations in leukocyte DNA methylome are associated to immunosuppression in severe clinical phenotypes of septic patients. Beltran-Garcia J, Casabo-Valles G, Osca-Verdegal R, Navarrete-Lopez P, Rodriguez-Gimillo M, Nacher-Sendra E, Ferrando-Sanchez C, Garcia-Lopez E, Pallardo F, Carbonell N, Mena-Molla S, Garcia-Gimenez J. Frontiers in Immunology. 2024 Jan 3:14:1333705. doi: 10.3389/fimmu.2023.1333705. PMID: 38235139

Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. Matuozzo D, Talouarn E, Marchal A, et al. Genome Medicine. 2024 Jan 6;16(1):6. doi: 10.1186/s13073-023-01278-0. PMID: 38184654

miRNAs Related to Immune Checkpoint Inhibitor Response: a systematic review. García-Giménez J, Saadi W, Ortega A, Lahoz A, Suay G, Carretero J, Pereda J, Fatmi A, Pallardó F, Mena-Molla S. International Journal of Molecular Sciences. 2024 Feb 1;25(3):1737. doi: 10.3390/ijms25031737. PMID: 38339019

Oxidative stress and metabolism meet epigenetic modulation in physical exercise. Garcia-Gimenez J, Canovas-Cervera I, Pallardo F. Free Radical Biology & Medicine. 2024 Jan 8:213:123-137. doi: 10.1016/j.freeradbiomed.2024.01.008. PMID: 38199289

Age-Related microRNA overexpression in Lafora disease male mice provides links between neuroinflammation and oxidative stress. Roma-Mateo C, Lorente-Pozo S, Marquez-Thibaut L, Moreno-Estelles M, Garces C, Gonzalez D, Lahuerta M, Aguado C, Garcia-Gimenez JL, Sanz P, Pallardo FV. International Journal of Molecular Sciences. 2023 Jan 6;24(2):1089. doi: 10.3390/ijms24021089. PMID: 36674605

Clinical outcomes of critical COVID-19 in HIV-Infected adults: a propensity score matched analysis. Cilloniz C, Motos A, Canseco J, Peñasco Y, Ricart P, Abril E, García J, Ortiz A, Mateo N, Sánchez-Miralles A, Franco N, Riera J, Ferrer R, Bustamante-Munguira E, Caballero J, de la Gándara A, Sancho S, Masclans J, Urrelo-Cerrón L, Carbonell N, Socías L, Barberà C, Lorente J, Rodríguez O, Menéndez R, de Gonzalo-Calvo D, Ceccato A, Fernandez-Barat L, Garcia-Gasulla D, Gabarrus A, Garcia-Vidal C, Moreno A, Barbé F, Miro J, Torres A. Archivos de Bronconeumologia. 2023 Nov;59(11):772-778. doi: 10.1016/j.arbres.2023.07.029. PMID: 37661559

Effects of intubation timing in patients with COVID-19 throughout the four waves of the pandemic: a matched analysis. Riera J, Barbeta E, Tormos A, Mellado-Artigas R, Ceccato A, Motos A, Fernandez-Barat L, Ferrer R, Garcia-Gasulla D, Penuelas O, Lorente J, Menendez R, Roca O, Palomeque A, Ferrando C, Sole-Violan J, Novo M, Boado M, Tamayo L, Estella A, Galban C, Trenado J, Huerta A, Loza A, Aguilera L, Garmendia J, Barbera C, Gumucio V, Socias L, Franco N, Valdivia L, Vidal P, Sagredo V, Ruiz-Garcia A, Varela I, Lopez J, Pozo J, Nieto M, Gomez J, Blandino A, Valledor M, Bustamante-Munguira E, Sanchez-Miralles A, Penasco Y, Barberan J, Ubeda A, Amaya-Villar R, Martin M, Jorge R, Caballero J, Marin J, Anon J, Sipmann F, Muniz G, Castellanos-Ortega A, Adell-Serrano B, Catalan M, de la Gandara A, Ricart P, Carbajales C, Rodriguez A, Diaz E, de la Torre M, Gallego E, Canton-Bulnes L, Carbonell N, Gonzalez J, de Gonzalo-Calvo D, Barbe F, Torres A. The European Respiratory Journal. 2023 Mar 2;61(3):2201426. doi: 10.1183/13993003.01426-2022. PMID: 36396142

Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells. Perez-Cremades D, Bueno-Beti C, Garcia-Gimenez J, Ibanez-Cabellos J, Pallardo F, Hermenegildo C, Novella S. Journal of Physiology and Biochemistry. 2023 May;79(2):251-260. doi: 10.1007/s13105-022-00935-z. PMID: 36464762

Hernández J,Chow CY,Chatras H,França PDD,Samuels ZV,Cornejo M,King GF,Lewis JS,Reiner T,Gonzales J. Development and Validation of Nerve-Targeted Bacteriochlorin Sensors. J. Am. Chem. Soc. 2023. 145. (26):p. 14276-14287. IF:14,400. (1).

Key factors associated with pulmonary sequelae in the follow-up of critically ill covid-19 patients. Gonzalez J, de Batlle J, Benitez I, Torres G, Santisteve S, Targa A, Gort-Paniello C, Moncusi-Moix A, Aguila M, Seck F, Ceccato A, Ferrer R, Motos A, Riera J, Fernandez L, Menendez R, Lorente J, Penuelas O, Garcia-Gasulla D, Penasco Y, Ricart P, Abril Palomares E, Aguilera L, Rodriguez A, Boado Varela M, Betere B, Pozo-Laderas J, Sole-Violan J, Salvador-Adell I, Novo M, Barberan J, Amaya Villar R, Garnacho-Montero J, Gomez J, Blandino Ortiz A, Tamayo Lomas L, Ubeda A, Catalan-Gonzalez M, Sanchez-Miralles A, Martinez Varela I, Jorge Garcia R, Franco N, Gumucio-Sanguino V, Bustamante-Munguira E, Valdivia L, Caballero J, Gallego E, Rodriguez C, Castellanos-Ortega A, Trenado J, Marin-Corral J, Albaiceta G, de la Torre M, Loza-Vazquez A, Vidal P, Anon J, Carbajales Perez C, Sagredo V, Carbonell N, Socias L, Barbera C, Estella A, Diaz E, de Gonzalo-Calvo D, Torres A, Barbe F. Archivos de Bronconeumologia. 2023 Apr;59(4):205-215. doi: 10.1016/j.arbres.2022.12.017. PMID: 36690515

Oxidative stress and epigenetics: miRNA involvement in rare autoimmune diseases. Ibanez-Cabellos J, Pallardo F, Garcia-Gimenez J, Seco-Cervera M. Antioxidants. 2023 Mar 25;12(4):800. doi: 10.3390/antiox12040800. PMID: 37107175

Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients. Galli F, Bindo F, Motos A, Fernández-Barat L, Barbeta E, Gabarrús A, Ceccato A, Bermejo-Martin J, Ferrer R, Riera J, Peñuelas O, Lorente J, de Gonzalo-Calvo D, Menéndez R, Gonzalez J, Misuraca S, Palomeque A, Amaya-Villar R, Añón J, Mariño A, Barberà C, Barberán J, Ortiz A, Bustamante-Munguira E, Caballero J, Cantón-Bulnes M, Pérez C, Carbonell N, Catalán-González M, de Frutos R, Franco N, Galbán C, Lago A, Gumucio-Sanguino V, de la Torre M, Díaz E, Estella A, Curto E, García-Garmendia J, Gómez J, Huerta A, García R, Loza-Vázquez A, Marin-Corral J, Delgado M, de la Gándara A, Varela I, Messa J, Albaiceta G, Nieto M, Novo M, Peñasco Y, Pérez-García F, Pozo-Laderas J, Ricart P, Sagredo V, Sánchez-Miralles A, Chinesta S, Roche-Campo F, Socias L, Solé-Violan J, Suarez-Sipmann F, Lomas L, Trenado J, Ubeda A, Valdivia L, Vidal P, Boado M, Rodríguez A, Antonelli M, Blasi F, Barbé F, Torres A. Intensive Care Medicine. 2023 Aug;49(8):934-945. doi: 10.1007/s00134-023-07161-1. PMID: 37507573

Proposal for antimicrobial therapy stewardship of lower respiratory tract infection in mechanically-ventilated patients based upon the Biofire Filmarray Pneumonia Plus panel results. Clari M, Carbonell N, Albert E, Navarro D. Enfermedades Infecciosas y Microbiologia Clinica (English ed.). 2023 Oct;41(8):521-523. doi: 10.1016/j.eimce.2023.04.022. PMID: 37838453

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. Matuozzo D, Talouarn E, Marchal A, Zhang P, Manry J, Seeleuthner Y, Zhang Y, Bolze A, Chaldebas M, Milisavljevic B, Gervais A, Bastard P, Asano T, Bizien L, Barzaghi F, Abolhassani H, Abou Tayoun A, Aiuti A, Alavi Darazam I, Allende LM, Alonso-Arias R, Arias AA, Aytekin G, Bergman P, Bondesan S, Bryceson YT, Bustos IG, Cabrera-Marante O, Carcel S, Carrera P, Casari G, Chaïbi K, Colobran R, Condino-Neto A, Covill LE, Delmonte OM, El Zein L, Flores C, Gregersen PK, Gut M, Haerynck F, Halwani R, Hancerli S, Hammarström L, Hatipoglu N, Karbuz A, Keles S, Kyheng C, Leon-Lopez R, Franco JL, Mansouri D, Martinez-Picado J, Metin Akcan O, Migeotte I, Morange PE, Morelle G, Martin-Nalda A, Novelli G, Novelli A, Ozcelik T, Palabiyik F, Pan-Hammarström Q, de Diego RP, Planas-Serra L, Pleguezuelo DE, Prando C, Pujol A, Reyes LF, Rivière JG, Rodriguez-Gallego C, Rojas J, Rovere-Querini P, Schlüter A, Shahrooei M, Sobh A, Soler-Palacin P, Tandjaoui-Lambiotte Y, Tipu I, Tresoldi C, Troya J, van de Beek D, Zatz M, Zawadzki P, Al-Muhsen SZ, Alosaimi MF, Alsohime FM, Baris-Feldman H, Butte MJ, Constantinescu SN, Cooper MA, Dalgard CL, Fellay J, Heath JR, Lau YL, Lifton RP, Maniatis T, Mogensen TH, von Bernuth H, Lermine A, Vidaud M, Boland A, Deleuze JF, Nussbaum R, Kahn-Kirby A, Mentre F, Tubiana S, Gorochov G, Tubach F, Hausfater P, Meyts I, Zhang SY, Puel A, Notarangelo LD, Boisson-Dupuis S, Su HC, Boisson B, Jouanguy E, Casanova JL, Zhang Q, Abel L, Cobat A. Genome Medicine. 2023 Apr 5;15(1):22. doi: 10.1186/s13073-023-01173-8. PMID: 37020259

Rationale for combined therapies in severe-to-critical COVID-19 patients. Gonzaga A, Andreu E, Hernández-Blasco L, Meseguer R, Al-Akioui-Sanz K, Soria-Juan B, Sanjuan-Gimenez J, Ferreras C, Tejedo J, Lopez-Lluch G, Goterris R, Maciá L, Sempere-Ortells J, Hmadcha A, Borobia A, Vicario J, Bonora A, Aguilar-Gallardo C, Poveda J, Arbona C, Alenda C, Tarín F, Marco F, Merino E, Jaime F, Ferreres J, Figueira J, Cañada-Illana C, Querol S, Guerreiro M, Eguizabal C, Martin-Quirós A, Robles-Marhuenda A, Pérez-Martínez A, Solano C, Soria B. Frontiers in Immunology. 2023 Sep 11:14:1232472. doi: 10.3389/fimmu.2023.1232472. PMID: 37767093

Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study. Cilloniz C, Motos A, Castaneda T, Gabarrus A, Barbe F, Torres A, CIBERESUCICOVID Project (COV20/00110 ISCIII). Journal of Infection. 2022 Dec 31:S0163-4453(22)00753-8. doi: 10.1016/j.jinf.2022.12.027. PMID: 36596315

The Biofire Filmarray Pneumonia Plus panel for management of lower respiratory tract infection in mechanically-ventilated patients in the COVID-19 era: a diagnostic and cost-benefit evaluation. Ferrer J, Clari M, Gimenez E, Carbonell N, Torres I, Blasco M, Albert E, Navarro D. Diagnostic Microbiology and Infectious Disease. 2023 Feb;105(2):115847. doi: 10.1016/j.diagmicrobio.2022.11584. PMID: 36403558

The intricate role of non-coding RNAs in sepsis-associated disseminated intravascular coagulation. Canovas Cervera I, Nacher Sendra E, Osca Verdegal R, Dolz Andres E, Beltran Garcia J, Rodriguez Gimillo M, Ferrando Sanchez C, Carbonell N, Garcia Gimenez JL. International Journal of Molecular Sciences. 2023 Jan 30;24(3):2582. doi: 10.3390/ijms24032582. PMID: 36768905

Utility of exome sequencing for the diagnosis of pediatric-onset neuromuscular diseases beyond diagnostic yield: a narrative review. Piñeros-Fernández MC, Morte B, García-Giménez JL. Neurological Sciences. 2023 Nov 22. doi: 10.1007/s10072-023-07210-z. PMID: 37989827

Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patients. Garcia-Gimenez J, Garcia-Lopez E, Mena-Molla S, Beltran-Garcia J, Osca-Verdegal R, Nacher-Sendra E, Aguado-Velasco C, Casabo-Valles G, Roma-Mateo C, Rodriguez-Gimillo M, Antunez O, Ferreres J, Pallardo F, Carbonell N. Journal of Translational Medicine. 2023 May 23;21(1):344. doi: 10.1186/s12967-023-04197-1. PMID: 37221624

Autoantibodies against type I IFNs in patients with critical influenza pneumonia. Zhang Q, Pizzorno A, Miorin L, Bastard P, Gervais A, Le Voyer T, Bizien L, Manry J, Rosain J, Philippot Q, Goavec K, Padey B, Cupic A, Laurent E, Saker K, Vanker M, Sarekannu K, Garcia-Salum T, Ferres M, Le Corre N, Sanchez-Cespedes J, Balsera-Manzanero M, Carratala J, Retamar-Gentil P, Abelenda-Alonso G, Valiente A, Tiberghien P, Zins M, Debette S, Meyts I, Haerynck F, Castagnoli R, Notarangelo LD, Gonzalez-Granado LI, Dominguez-Pinilla N, Andreakos E, Triantafyllia V, Rodriguez-Gallego C, Sole-Violan J, Ruiz-Hernandez JJ, Rodriguez de Castro F, Ferreres J, Briones M, Wauters J, Vanderbeke L, Feys S, Kuo CY, Lei WT, Ku CL, Tal G, Etzioni A, Hanna S, Fournet T, Casalegno JS, Queromes G, Argaud L, Javouhey E, Rosa-Calatrava M, Cordero E, Aydillo T, Medina RA, Kisand K, Puel A, Jouanguy E, Abel L, Cobat A, Trouillet-Assant S, Garcia-Sastre A, Casanova JL. Journal of Experimental Medicine. 2022 Nov 7;219(11):e20220514. doi: 10.1084/jem.20220514. PMID: 36112363

CAPA in progress: a new real-life approach for the management of critically ill COVID-19 patients. Carbonell N, Alcaraz M, Serrano-Lazaro A, Rodriguez-Gimillo M, Ramos D, Ros F, Ferrer J, Blasco M, Navarro D, Clari M. Biomedicines. 2022 Jul 13;10(7):1683. doi: 10.3390/biomedicines10071683. PMID: 35884988

Characterization of Early Peripheral Immune Responses in Patients with Sepsis and Septic Shock. Beltran-Garcia J, Osca-Verdegal R, Javega B, Herrera G, O’Connor J, Garcia-Lopez E, Casabo-Valles G, Rodriguez-Gimillo M, Ferreres J, Carbonell N, Pallardo F, Garcia-Gimenez J. Biomedicines. 2022 Feb 23;10(3):525. doi: 10.3390/biomedicines10030525. PMID: 35327327

CIBERER: Spanish national network for research on rare diseases: a highly productive collaborative initiative. Luque J, Mendes I, Gomez B, Morte B, de Heredia M, Herreras E, Corrochano V, Bueren J, Gallano P, Artuch R, Fillat C, Perez-Jurado L, Montoliu L, Carracedo A, Millan J, Webb S, Palau F, Lapunzina P, Pallardo Calatayud F, CIBERER Network. Clinical Genetics. 2022 May;101(5-6):481-493. doi: 10.1111/cge.14113. PMID: 35060122

Clinical and immunological aspects of microRNAs in neonatal sepsis. Fatmi A, Chabni N, Cernada M, Vento M, Gonzalez-Lopez M, Aribi M, Pallardo FV, Garcia-Gimenez JL. Biomedicine & Pharmacotherapy. 2021 Nov 19;145:112444. doi: 10.1016/j.biopha.2021.112444. PMID: 34808550

Combined kinetic analysis of SARS-CoV-2 RNAemia, N-antigenemia and virus-specific antibodies in critically ill adult COVID-19 patients. Costa R, Alberola J, Olea B, Gozalbo-Rovira R, Gimenez E, Cuevas-Ferrando E, Torres I, Albert E, Carbonell N, Ferreres J, Sanchez G, Rodriguez-Diaz J, Blasco M, Navarro D. Scientific Reports. 2022 May 18;12(1):8273. doi: 10.1038/s41598-022-12461-5. PMID: 35585163

Extracellular histones activate endothelial NLRP3 inflammasome and are associated with a severe sepsis phenotype. Beltrán-García J, Osca-Verdegal R, Pérez-Cremades D, Novella S, Hermenegildo C, Pallardó FV, García-Giménez JL. Journal of Inflammation Research. 2022 Jul 25;15:4217-4238. doi: 10.2147/JIR.S363693. PMID: 35915852

Histone citrullination mediates a protective role in endothelium and modulates inflammation. Osca-Verdegal R, Beltran-Garcia J, Paes A, Nacher-Sendra E, Novella S, Hermenegildo C, Carbonell N, Garcia-Gimenez J, Pallardo F. Cells. 2022 Dec 15;11(24):4070. doi: 10.3390/cells11244070. PMID: 36552833

Identification of circulating miRNAs differentially expressed in patients with Limb-girdle, Duchenne or facioscapulohumeral muscular dystrophies. Garcia-Gimenez JL, Garcia-Trevijano ER, Aviles-Alia AI, Ibanez-Cabellos JS, Bovea-Marco M, Bas T, Pallardo FV, Vina JR, Zaragoza R. Orphanet Journal of Rare Diseases. 2022 Dec 27;17(1):450. doi: 10.1186/s13023-022-02603-3. PMID: 36575500

Initial SARS-CoV-2 RNA load in nasopharyngeal specimens is not associated with severity and midterm resolution of pneumonia in COVID-19 patients. Costa R, Signes-Costa J, Olea B, Tarraso J, Carbonell N, Blasco M, Navarro D. Journal of Infection. 2022 Dec;85(6):702-769. doi: 10.1016/j.jinf.2022.10.031. PMID: 36346264

Long non-coding RNAs as epigenetic regulators of immune checkpoints in cancer immunity. Saadi W, Fatmi A, Pallardo FV, Garcia-Gimenez JL, Mena-Molla S. Cancers. 2022 Dec 28;15(1):184. doi: 10.3390/cancers15010184. PMID: 36612180

Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study. Torres A, Motos A, Cilloniz C, Ceccato A, Fernandez-Barat L, Gabarrus A, Bermejo-Martin J, Ferrer R, Riera J, Perez-Arnal R, Garcia-Gasulla D, Penuelas O, Lorente J, de Gonzalo-Calvo D, Almansa R, Menendez R, Palomeque A, Villar R, Anon J, Marino A, Barbera C, Barberan J, Ortiz A, Boado M, Bustamante-Munguira E, Caballero J, Canton-Bulnes M, Perez C, Carbonell N, Catalan-Gonzalez M, de Frutos R, Franco N, Galban C, Gumucio-Sanguino V, de la Torre M, Diaz E, Estella A, Gallego E, Garmendia J, Gomez J, Huerta A, Garcia R, Loza-Vazquez A, Marin-Corral J, Delgado M, de la Gandara A, Varela I, Messa J, Albaiceta G, Nieto M, Novo M, Penasco Y, Perez-Garcia F, Pozo-Laderas J, Ricart P, Sagredo V, Sanchez-Miralles A, Chinesta S, Serra-Fortuny M, Socias L, Sole-Violan J, Suarez-Sipmann F, Lomas L, Trenado J, Ubeda A, Valdivia L, Vidal P, Barbe F. Intensive Care Medicine. 2022 Jul;48(7):850-864. doi: 10.1007/s00134-022-06726-w. PMID: 35727348

MicroRNA-132 is overexpressed in fetuses with late-onset fetal growth restriction. Morales-Rosello J, Loscalzo G, Garcia-Lopez E, Garcia-Gimenez J, Perales-Marin A. Health Science Reports. 2022 Mar 15;5(2):e558. doi: 10.1002/hsr2.558. PMID: 35317418

MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction. Morales-Rosello J, Loscalzo G, Garcia-Lopez EM, Ibanez Cabellos JS, Garcia-Gimenez JL, Canada Martinez AJ, Perales Marin A. Epigenetics. 2022 Nov;17(11):1345-1356. doi: 10.1080/15592294.2021.2023271. PMID: 34969362

Monitoring of Torque Teno virus DNAemia in critically ill COVID-19 patients: may it help to predict clinical outcomes?. Forque L, Albert E, Gimenez E, Torres I, Carbonell N, Ferreres J, Blasco M, Navarro D. Journal of Clinical Virology. 2022 Jan 23;148:105082. doi: 10.1016/j.jcv.2022.105082. PMID: 35091226

Neurodevelopmental outcome and epigenetic changes at 2 years associated with the oxygen load received upon postnatal stabilization: a pilot study. Lorente-Pozo S, Boronat N, Parra-Llorca A, Lara-Canton I, Solaz-Garcia A, Soler J, Buso E, Casabo-Valles G, Garcia-Gimenez J, Pallardo F, Vento M. Neonatology. 2022;119(5):575-584. doi: 10.1159/000525305. PMID: 35760056

Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: a multicenter, observational study. Benitez I, de Batlle J, Torres G, Gonzalez J, De Gonzalo-Calvo D, Targa A, Gort-Paniello C, Moncusi-Moix A, Ceccato A, Fernandez-Barat L, Ferrer R, Garcia-Gasulla D, Menendez R, Motos A, Penuelas O, Riera J, Bermejo-Martin J, Penasco Y, Ricart P, Delgado M, Aguilera L, Rodriguez A, Varela M, Suarez-Sipmann F, Pozo-Laderas J, Sole-Violan J, Nieto M, Novo M, Barberan J, Villar R, Garnacho-Montero J, Garcia-Garmendia J, Gomez J, Lorente J, Ortiz A, Lomas L, Lopez-Ramos E, Ubeda A, Catalan-Gonzalez M, Sanchez-Miralles A, Varela I, Garcia R, Franco N, Gumucio-Sanguino V, Garcia A, Bustamante-Munguira E, Valdivia L, Caballero J, Gallego E, de la Gandara A, Castellanos-Ortega A, Trenado J, Marin-Corral J, Albaiceta G, de la Torre M, Loza-Vazquez A, Vidal P, Messa J, Anon J, Perez C, Sagredo V, Bofill N, Carbonell N, Socias L, Barbera C, Estella A, Mendez M, Diaz E, Lago A, Torres A, Barbe F. Lancet Regional Health-Europe. 2022 May 29;18:100422. doi: 10.1016/j.lanepe.2022.100422. PMID: 35655660

SARS-CoV-2 N-antigenemia in critically ill adult COVID-19 patients: frequency and association with inflammatory and tissue-damage biomarkers. Olea B, Albert E, Torres I, Gozalbo-Rovira R, Carbonell N, Ferreres J, Poujois S, Costa R, Colomina J, Rodriguez J, Blasco M, Navarro D. Journal of Medical Virology. 2022 Jan;94(1):222-228. doi: 10.1002/jmv.27300. PMID: 34449894

SARS-CoV-2-reactive IFN-gamma-producing CD4+ and CD8+ T cells in blood do not correlate with clinical severity in unvaccinated critically ill COVID-19 patients. Olea B, Albert E, Gimenez E, Torres I, Amat P, Remigia M, Alberola J, Carbonell N, Ferreres J, Blasco M, Navarro D. Scientific Reports. 2022 Aug 22;12(1):14271. doi: 10.1038/s41598-022-18659-x. PMID: 35995830

The endothelial glycocalyx and neonatal sepsis. Fatmi A, Saadi W, Beltran-Garcia J, Garcia-Gimenez JL, Pallardo FV. International Journal of Molecular Sciences. 2022 Dec 26;24(1):364. doi: 10.3390/ijms24010364. PMID: 36613805

The genetic diversity and dysfunctionality of catalase associated with a worse outcome in Crohn’s Disease. Iborra M, Moret I, Buso E, Garcia-Gimenez J, Ricart E, Gisbert J, Cabre E, Esteve M, Marquez-Mosquera L, Garcia-Planella E, Guardiola J, Pallardo F, Serena C, Algaba-Chueca F, Domenech E, Nos P, Beltran B. International Journal of Molecular Sciences. 2022 Dec 14;23(24):15881. doi: 10.3390/ijms232415881. PMID: 36555526

Use of circular RNAs in diagnosis, prognosis and therapeutics of renal cell carcinoma. Osca Verdegal R, Beltran Garcia J, Gorriz J, Jabaloyas J, Pallardo F, Garcia Gimenez J. Frontiers in Cell and Developmental Biology. 2022 Jun 22;10:879814. doi: 10.3389/fcell.2022.879814. PMID: 35813211

Alvarez NH,Bauer D,Hernández J,Lewis JS. Recent Advances in Radiometals for Combined Imaging and Therapy in Cancer. ChemMedChem. 2021. 16(19):p. 2909-2941. IF:3,540. (3).

Braga M,Leow CH,Gil JH,Teh JH,Carroll L,Long NJ,Tang MX,Aboagye EO. Investigating CXCR4 expression of tumor cells and the vascular compartment: A multimodal approach. PLoS One. 2021. 16. (11):e0260186. IF:3,752. (2).

Comparative analysis of chromatin-delivered biomarkers in the monitoring of sepsis and septic shock: a pilot study. Beltran-Garcia J, Manclus J, Garcia-Lopez E, Carbonell N, Ferreres J, Rodriguez-Gimillo M, Garces C, Pallardo F, Garcia-Gimenez J, Montoya A, Roma-Mateo C. International Journal of Molecular Sciences. 2021 Sep 14;22(18):9935. doi: 10.3390/ijms22189935. PMID: 34576097

DNA Methylation Analysis to Unravel Altered Genetic Pathways Underlying Early Onset and Late Onset Neonatal Sepsis. A Pilot Study. Lorente-Pozo S, Navarrete P, Garzón MJ, Lara-Cantón I, Beltrán-García J, Osca-Verdegal R, Mena-Mollá S, García-López E, Vento M, Pallardó FV, García-Giménez JL. Frontiers in Immunology. 2021 Feb 15;12:622599. doi: 10.3389/fimmu.2021.622599. PMID: 33659006

Gonzales J,Hernández J,Wilson TC,Adilbay D,Cornejo M,Franca PDD,Guru N,Schroeder CI,King GF,Lewis JS,Reiner T. Bimodal Imaging of Mouse Peripheral Nerves with Chlorin Tracers. Mol. Pharm. 2021. 18. (3):p. 940-951. IF:5,364. (1).

Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers. Garcia-Gimenez J, Mena-Molla S, Tarazona-Santabalbina F, Vina J, Gomez-Cabrera M, Pallardo F. International Journal of Environmental Research and Public Health. 2021 Feb 15;18(4):1883. doi: 10.3390/ijerph18041883. PMID: 33672064

Lower respiratory tract and plasma SARS-CoV-2 RNA load in critically ill adult COVID-19 patients: Relationship with biomarkers of disease severity. Olea B, Albert E, Torres I, Gozalbo-Rovira R, Carbonell N, Ferreres J, Poujois S, Costa R, Colomina J, Rodriguez J, Blasco M, Navarro D. Journal of Infection. 2021 Sep;83(3):381-412. doi: 10.1016/j.jinf.2021.05.036. PMID: 34087349

Overexpression of microRNAs miR-25-3p, miR-185-5p and miR-132-3p in Late Onset Fetal Growth Restriction, Validation of Results and Study of the Biochemical Pathways Involved. Loscalzo G, Scheel J, Ibañez-Cabellos JS, García-Lopez E, Gupta S, García-Gimenez JL, Mena-Mollá S, Perales-Marín A, Morales-Roselló J. International Journal of Molecular Sciences. 2021 Dec 28;23(1):293. doi: 10.3390/ijms23010293. PMID: 35008715

Oxidative stress and rare diseases: from molecular crossroads to therapeutic avenues. Roma-Mateo C, Garcia-Gimenez J. Antioxidants. 2021 Apr 16;10(4):617. doi: 10.3390/antiox10040617. PMID: 33923815

Oxidative stress-mediated alterations in histone post-translational modifications. Garcia-Gimenez J, Garces C, Roma-Mateo C, Pallardo F. Free Radical Biology & Medicine. 2021 Jul;170:6-18. doi: 10.1016/j.freeradbiomed.2021.02.027. PMID: 33689846

Role of microRNAs as biomarkers in sepsis-associated encephalopathy. Osca-Verdegal R, Beltran-Garcia J, Pallardo FV, Garcia-Gimenez JL. Molecular Neurobiology. 2021 Sep;58(9):4682-4693. doi: 10.1007/s12035-021-02445-3. PMID: 34160774

Role of non-coding RNAs as biomarkers of deleterious cardiovascular effects in sepsis. Beltran Garcia J, Osca Verdegal R, Nacher Sendra E, Cardona Monzonis A, Sanchis Gomar F, Carbonell N, Pallardo FV, Lavie CJ, Garcia Gimenez JL. Progress in Cardiovascular Diseases. 2021;68:70-77. doi: 10.1016/j.pcad.2021.07.005. PMID: 34265333

Teh JH,Braga M,Allott L,Barnes C,Hernandez J,Tang MX,Aboagye EO,Long N. A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles. Chem. Commun. 2021. 57. (88):p. 11677-11680. IF:6,065. (2).

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients. Torres A, Motos A, Riera J, Fernandez-Barat L, Ceccato A, Perez-Arnal R, Garcia-Gasulla D, Penuelas O, Lorente J, Rodriguez A, de Gonzalo-Calvol D, Almansa R, Gabarrus A, Menendez R, Bermejo-Martin J, Ferrer R, Villar R, Anon J, Barbera C, Barberan J, Ortiz A, Bustamante-Munguira E, Caballero J, Carbajales C, Carbonell N, Catalan-Gonzalez M, Galban C, Gumucio-Sanguino V, de la Torre M, Diaz E, Estella A, Gallego E, Garmendia J, Garnacho-Montero J, Gomez J, Huerta A, Garcia R, Loza-Vazquez A, Marin-Corral J, de la Gandara A, Varela I, Messa J, Albaiceta G, Novo M, Penasco Y, Pozo-Laderas J, Ricart P, Salvador-Ade I, Sanchez-Miralles A, chinesta S, Socias L, Sole-Violan J, Sipmann F, Lomas L, Trenado J, Barbe F, CIBERESUCICOVID Project Cov20 0011, ISCIII. Critical Care. 2021 Sep 13;25(1):331. doi: 10.1186/s13054-021-03727-x. PMID: 34517881

Projects
Reference: RYC2022-037234-I
Title: Development of CXCR4-specific PET imaging agents in neuroendocrine tumors by using a multidisciplinary approach(Smart_PET_tracers)
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: JAVIER HERNÁNDEZ GIL
Duration: 2024 – 2029
Total budget: 244.350 €
Reference: PI22/00990
Title: Biomarcadores de pronóstico de Escoliosis Idiopática en Adolescentes
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Salvador Mena Mollá
Duration: 2023 – 2025
Total budget: 123.420 €
Reference: DTS21/00193
Title: Test basados en péptidos spike-in y espectrometría de masas para la cuantificación de histonas circulantes y proteína APC, para el manejo clínico del paciente crítico
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Jose Luis García Giménez
Duration: 2022 – 2023
Total budget: 122.100 €
Reference: CPP2021-008643
Title: Identificación y validación de biomarcadores mediante el uso de las ómicas y la Inteligencia Artificial para el diagnóstico temprano y mejora del manejo clínico de la sepsis
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Edurne Carbonell
Duration: 2022 – 2024
Total budget: 150.269 €
Reference: FIPSE 3819-21
Title: Valorización e internacionalización de HistShock, un test IVD para el diagnóstico y pronóstico de la sepsis y el shock séptico
Funding body: Fundación para la Innovación y Prospectiva en Salud en España (FIPSE)
Principal Investigator: José Luis García Giménez
Duration: 2021 – 2021
Total budget: 30.000 €
Reference: INNTA2/2020/4
Title: Incorporación de investigadores y tecnólogos para proyectos de innovación en empresas
Funding body: Agencia Valenciana de Innovación (AVI)
Principal Investigator: José Luis García Giménez
Duration: 2020 – 2021
Total budget: 33.013 €
Reference: INNVA1/2020/85
Title: Valorización, estrategia de protección y transferencia de un método de diagnóstico y pronóstico de la sepsis y el shock séptico
Funding body: Agencia Valenciana de la Innovación-AVI Generalitat Valenciana
Principal Investigator: Jose Luis García Giménez
Duration: 2020 – 2021
Total budget: 110.670 €
Reference: PI19/00994
Title: Biomarcadores epigenéticos en sepsis y su implicación en inmunosupresión y futuras comorbilidades en supervivientes
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: José Luis García Giménez
Duration: 2020 – 2022
Total budget: 111.320 €
Reference: RTC2019-006825-1
Title: Potencial de la leriglitazona para el tratamiento de enfermedades asociadas a la acumulación de hierro, distrofias y enfermedades neuromusculares
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Pilar González Cabo
Duration: 2020 – 2023
Total budget: 90.000 €
Reference: ACCI-2018
Title: Validación de biomarcadores para el diagnóstico y el pronóstico de la sepsis neonatal
Funding body: CIBER de Enfermedades Raras (CIBERER-ISCIII)
Principal Investigator: José Luis García Giménez
Duration: 2019 – 2020
Total budget: 49.500 €
Reference: PI16/01036
Title: Epigenética e inmunosupresión. Uso de las histonas circulantes y sus modificaciones posttraduccionales como biomarcadores de diagnóstico y pronóstico en sepsis y shock séptico
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: José Luis García Giménez
Duration: 2017 – 2019
Total budget: 87.725 €
Reference:
Title: Co-financiación Investigadores
Funding body: CENTRO DE INVESTIGACION PRINCIPE FELIPE; CONSELLERIA DE SANIDAD
Principal Investigator: JOSEP GAVARA DOÑATE
Duration: –
Total budget: 3.347.450 €
Reference: PID2023-151284OB-I00
Title: Development of CXCR4-specific theranostic agents in Colorectal cancer (Smart_PET_Tracers).
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: JAVIER HERNÁNDEZ GIL
Duration: –
Total budget: 0 €
Reference: PI24/01194
Title: Desarrollo de radioteranósticos específicos de CXR4 en cáncer colorrectal.
Funding body: INSTITUTO SALUD CARLOS III
Principal Investigator: JAVIER HERNÁNDEZ GIL
Duration: –
Total budget: 0 €
+ Info
Title: The study of the formation of DNA damage by [2+2] photocycloaddition and its photo-repair by single or multiphoton absorption
Doctoral candidate: Juan Antonio Soler Orenes
Director(s): Virginie L. Lhiaubet y Javier Hernández Gil
Date of the defense: 20/12/2024
University: University Politécnica de Valencia

Title: Identificación de los mecanismos epigenéticos relacionados con los fenómenos de inmunosupresión en sepsis y su uso como biomarcadores de pronóstico
Doctoral candidate: Osca Verdegal, Rebeca
Director(s):
Date of the defense: 19/05/2023
University: University de Valencia

Title: Potencial uso de la tecnología basada en microARNs para el diagnóstico y pronóstico de la escoliosis idiopática del adolescente
Doctoral candidate: Berenguer Pascual, Ester
Director(s): García Giménez, José Luis; Pérez Machado, Giselle; Mena Mollá Salvador
Date of the defense: 10/02/2022
University: Universitat de València

Title: Uso de las histonas circulantes y sus modificaciones post-traduccionales como biomarcadores en sepsis y shock séptico
Doctoral candidate: Beltrán García, Jesús
Director(s): García Giménez, José Luis; Pallardó Calatayud, Federico
Date of the defense: 20/01/2022
University: Universitat de València

Title: Influencia de factores epigeneticos en el desarrollo de la escoliosis idiopatica del adolescente
Doctoral candidate: Rubio Belmar, Pedro Antonio
Director(s): Bas Hermida, Teresa; García Giménez, José Luis
Date of the defense: 27/05/2021
University: Universitat de València

Title: Búsqueda de MIARNS en fluido crevicular gingival: expresión diferencial en sujetos con periodontitis crónica avanzada
Doctoral candidate: Almiñana Pastor, Pedro José
Director(s): García Giménez, José Luis; Bagán Sebastián, Jose Vicente; López Roldán, Andrés
Date of the defense: 04/03/2021
University: Universitat de València