Research Group in Medical Chemistry for Drug Development
Metabolism and Organic Damage Area
Peroxisome proliferator activator receptors (PPARs)Liver X receptors (LXR)
Dopamine receptors
Biomarkers of inflammation
Coordinator
STAFF
Collaborating Researchers
Diego Cortés Martínez
Jordi Ferri Císcar
Nurse
Technicians
Laura Vila Dasí
Administrative assistant
Publications
Synthesis of 2-aminopropyl benzopyran derivatives as potential agents against triple-negative breast cancer. García A, Torres-Ruiz S, Vila L, Villarroel-Vicente C, Bernabeu A, Eroles P, Cabedo N, Cortes D. RSC Medicinal Chemistry. 2023 Oct 4;14(11):2327-2341. doi: 10.1039/d3md00385j. PMID: 38020071
Synthesis and biological studies of polycerasoidol and trans-delta-tocotrienolic acid derivatives as PPARalpha and/or PPARgamma agonists. Vila L, Cabedo N, Villarroel-Vicente C, Garcia A, Bernabeu A, Hennuyer N, Staels B, Franck X, Figadere B, Sanz MJ, Cortes D. Bioorganic & Medicinal Chemistry. 2022 Jan 1;53:116532. doi: 10.1016/j.bmc.2021.116532. PMID: 34863066
Projects
Title: Desarrollo de nuevos moduladores multidiana de receptores nucleares y biomarcadores lipídicos para el tratamiento del síndrome metabólico y las comorbilidades asociadas
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Nuria Cabedo Escrig
Duration: 2022 – 2024
Total budget: 174.240 €
Title: Desarrollo químico y farmacológico de nuevos fármacos “multidiana” en el tratamiento de la diabetes mellitus tipo 2 y la enfermedad cardiovascular asociada
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Nuria Cabedo Escrig
Duration: 2019 – 2022
Total budget: 61.710 €
Title: Multi-target paradigm for innovative ligand identification in the drug discovery process (MuTaLig)
Funding body: European Commission
Principal Investigator: Stefano Alcaro
Duration: 2016 – 2020
Total budget:
Title: Synthesis and pharmacological evaluation of new dual PPARalpha/gamma agonists as new therapeutic tools in the control of cardiometabolic disorders
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Nuria Cabedo Escrig
Duration: 2016 – 2021
Total budget: 121.500 €