Dr. Rafael Badenes Quiles

Principal Investigator
Research Group on Anesthesiology and Reanimation

Presentation

Dr. Badenes studied at the Faculty of Medicine of the University of Valencia (1995-2001), obtaining the title of specialist in Anesthesiology and Intensive Care via MIR at the Hospital Clínico Universitario de Valencia in 2006. He received his PhD from the Universidad Autónoma de Madrid in 2011 and obtained the Master’s Degree in Clinical Trials from the University of Valencia in 2016.

Since 2022 he has been Head of Department of Anesthesiology, Critical Care and Pain Clinic at the Hospital Clínico Universitario de Valencia. He has been Hospital Transplant Coordinator of the Hospital itself since 2016, Sectorial Transplant Coordinator and responsible for the mobile ECMO program for transplants in the Valencian Community since 2017, and since 2023, the Director of the Trasplant Program of the Valencian Community.

He has been Full Professor in the Department of Surgery since 2020, serving as the Secretary of the Department of Surgery at the University of Valencia and Coordinator of the Teaching Unit of Anesthesiology and Critical Care. He coordinates two core subjects in the Medical Degree program at the University of Valencia. His expertise stands out as a certified instructor in major international courses in the field, such as ATLS (Advanced Trauma Life Support), ETC (European Trauma Course), and FCCS (Fundamental Critical Care Support). He is a corresponding member of the Royal Academy of Medicine and Allied Sciences of the Valencian Community.

Additionally, he obtained the European Diploma in Anesthesiology and Intensive Care in 2014 by the ESAIC (European Society of Anesthesiology and Intensive Care), being an examiner for this Diploma since 2016.

His research activity has been carried out in parallel to his clinical activity, putting into practice translational research in the field of neurocritical care, organ donation, and transplantation. In this regard, his involvement in more than 100 national and international projects as both principal investigator and sub-investigator. He has completed fellowships in the Departments of Anesthesiology and Intensive Care at Vanderbilt University Medical Center, Erasme Hospital of the Université Libre de Bruxelles, and Policlinico Umberto I at Sapienza University of Rome.

He is very involved with the main national and international Anesthesiology and Intensive Care Scientific Societies. His role as Spanish representative in the NeuroIntensive Care section of the European Society of Intensive Care Medicine stands out. He is an elected member of the European Council for Organ Donation and Transplantation

Within the editorial activity, he is a member of the Editorial Board of indexed journals in the field of anesthesiology and intensive care and a reviewer for high-impact journals, not only in anesthesiology and intensive care but also in some of the highest impact journals worldwide, such as The Lancet. He has 170 publications in the most prestigious indexed journals in his field, with a total of 9,200 citations and a cumulative impact factor exceeding 1,500. His h-index is 37.

Principal
Investigator
Dr. Rafael Badenes Quiles

rafael.badenes@uv.es; rbadenes@uv.es

Publications
Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study. Robba C, Battaglini D, Abbas A, Sarrió E, Cinotti R, Asehnoune K, Taccone F, Rocco P, Schultz M, Citerio G, Stevens R, Badenes R. Intensive Care Medicine. 2024 Jan 31. doi: 10.1007/s00134-023-07305-3. PMID: 38294526Correction: Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study. Robba C, Battaglini D, Abbas A, Sarrió E, Cinotti R, Asehnoune K, Taccone FS, Rocco PR, Schultz MJ, Citerio G, Stevens RD, Badenes R. Intensive Care Medicine. 2024 Feb 23. doi: 10.1007/s00134-024-07358-y. PMID: 38393334

Early management of adult traumatic spinal cord injury in patients with polytrauma: a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS). Picetti E, Demetriades A, Catena F, Aarabi B, Abu-Zidan F, Alves O, Ansaloni L, Armonda R, Badenes R, Bala M, Balogh Z, Barbanera A, Bertuccio A, Biffl W, Bouzat P, Buki A, Castano-Leon A, Cerasti D, Citerio G, Coccolini F, Coimbra R, Coniglio C, Costa F, De Iure F, Depreitere B, Fainardi E, Fehlings M, Gabrovsky N, Godoy D, Gruen P, Gupta D, Hawryluk G, Helbok R, Hossain I, Hutchinson P, Iaccarino C, Inaba K, Ivanov M, Kaprovoy S, Kirkpatrick A, Klein S, Kolias A, Konovalov N, Lagares A, Lippa L, Loza-Gomez A, Luoto T, Maas A, Maciejczak A, Maier R, Marklund N, Martin M, Melloni I, Mendoza-Lattes S, Meyfroidt G, Munari M, Napolitano L, Okonkwo D, Otomo Y, Papadopoulos M, Petr O, Peul W, Pudkrong A, Qasim Z, Rasulo F, Reizinho C, Ringel F, Rizoli S, Rostami E, Rubiano A, Russo E, Sarwal A, Schwab J, Servadei F, Sharma D, Sharif S, Shiban E, Shutter L, Stahel P, Taccone F, Terpolilli N, Thome C, Toth P, Tsitsopoulos P, Udy A, Vaccaro A, Varon A, Vavilala M, Younsi A, Zackova M, Zoerle T, Robba C. World Journal of Emergency Surgery. 2024 Jan 18;19(1):4. doi: 10.1186/s13017-023-00525-4. PMID: 38238783

Effect of aging on the human myometrium at single-cell resolution. Punzon-Jimenez P, Machado-Lopez A, Perez-Moraga R, Llera-Oyola J, Grases D, Galvez-Viedma M, Sibai M, Satorres-Perez E, Lopez-Agullo S, Badenes R, Ferrer-Gomez C, Porta-Pardo E, Roson B, Simon C, Mas A. Nature Communications. 2024 Jan 31;15(1):945. doi: 10.1038/s41467-024-45143-z. PMID: 38296945

Anesthetic management of endovascular neurosurgical procedures in acute ischemic stroke patients: a systematic review of meta-analyses. Viderman D, Bilotta F, Badenes R, Abdildin Y. Revista Espanola de Anestesiologia y Reanimacion. 2023 Sep 6;S2341-1929(23)00142-7. doi: 10.1016/j.redare.2023.02.007. PMID: 37678462Artificial intelligence in resuscitation: a scoping review. Viderman D, Abdildin Y, Batkuldinova K, Badenes R, Bilotta F. Journal of Clinical Medicine. 2023 Mar 14;12(6):2254. doi: 10.3390/jcm12062254. PMID: 36983255

Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium. Sperotto F, Gutierrez-Sacristan A, Makwana S, Li X, Rofeberg V, Cai T, Bourgeois F, Omenn G, Hanauer D, Saez C, Bonzel C, Bucholz E, Dionne A, Elias M, Garcia-Barrio N, Gonzalez T, Issitt R, Kernan K, Laird-Gion J, Maidlow S, Mandl K, Ahooyi T, Moraleda C, Morris M, Moshal K, Pedrera-Jimenez M, Shah M, South A, Spiridou A, Taylor D, Verdy G, Visweswaran S, Wang X, Xia Z, Zachariasse J, Newburger J, Avillach P. Eclinicalmedicine. 2023 Sep 14:64:102212. doi: 10.1016/j.eclinm.2023.102212. PMID: 37745025

Cocaine and ischemic or hemorrhagic stroke: a systematic review and meta-analysis of clinical evidence. Rendon L, Malta S, Leung J, Badenes R, Nozari A, Bilotta F. Journal of Clinical Medicine. 2023 Aug 10;12(16):5207. doi: 10.3390/jcm12165207. PMID: 37629248

Early sedation in traumatic brain injury: a multicentre international observational study. Russo G, Harrois A, Anstey J, van der Jagt M, Taccone F, Udy A, Citerio G, Duranteau J, Ichai C, Badenes R, Prowle J, Ercole A, Oddo M, Schneider A, Wolf S, Helbok R, Nelson D, Cooper J. Critical Care and Resuscitation. 2023 Oct 16;24(4):319-329. doi: 10.51893/2022.4.OA2. PMID: 38047010

Effect of ketamine on postoperative neurocognitive disorders: a systematic review and meta-analysis. Viderman D, Aubakirova M, Nabidollayeva F, Yegembayeva N, Bilotta F, Badenes R, Abdildin Y. Journal of Clinical Medicine. 2023 Jun 27;12(13):4314. doi: 10.3390/jcm12134314. PMID: 37445346

Extremely missing numerical data in Electronic Health Records for machine learning can be managed through simple imputation methods considering informative missingness: a comparative of solutions in a COVID-19 mortality case study. Ferri P, Romero-Garcia N, Badenes R, Lora-Pablos D, Morales T, Gomez de la Camara A, Garcia-Gomez J, Saez C. Computer Methods and Programs in Biomedicine. 2023 Sep 7;242:107803. doi: 10.1016/j.cmpb.2023.107803. PMID: 37703700

Heart rate variability for outcome prediction in intracerebral and subarachnoid hemorrhage: a systematic review. Marino L, Badenes R, Bilotta F. Journal of Clinical Medicine. 2023 Jun 28;12(13):4355. doi: 10.3390/jcm12134355. PMID: 37445389

Individualized thresholds of hypoxemia and hyperoxemia and their effect on outcome in acute brain injured patients: a secondary analysis of the ENIO Study. Robba C, Battaglini D, Cinotti R, Asehnoune K, Stevens R, Taccone F, Badenes R, Pelosi P. Neurocritical Care. 2023 Jun 15. doi: 10.1007/s12028-023-01761-x. PMID: 37322325

Neurological pupil index and delayed cerebral ischemia after subarachnoid hemorrhage: a retrospective multicentric study. Bogossian E, Ortiz A, Esposito V, Caricato A, Shinotsuka C, Lopez B, Gianni G, Macchini E, Sanchez R, Pisapia L, Turon R, Goncalves B, Badenes R, Kurtz P, Taccone F. Neurocritical Care. 2023 Aug;39(1):116-124. doi: 10.1007/s12028-023-01744-y. PMID: 37225941

Outcomes in patients with COVID-19 with acute encephalopathy and coma: an international prospective study. Legriel S, Badenes R, Engrand N, Mendoza-Trujillo R, Soulier P, Benghanem S, Pizzi M, Maciel C, Chelly J, Zuber B, Labruyere M, Plantefeve G, Jacq G, Galbois A, Launey Y, Argaud L, Lesieur O, Ferre A, Paul M, Guillon A, Bailly P, Beuret P, de-Carne MC, Siami S, Benzekri D, Colin G, Gaviria L, Aldana JL, Bruel C, Stoclin A, Sedillot N, Geri G, Samano D, Sobczak E, Swafford E, O’Phelan K, Meffert A, Holleville M, Silva S, Alves da Costa MJ, Mejia J, Alkhachroum A. Neurology. 2023 May 30;100(22):e2247-e2258. doi: 10.1212/WNL.0000000000207263. PMID: 37041081

Outcomes of lung and liver transplantation after simultaneous recovery using abdominal normothermic regional perfusion in donors after the circulatory determination of death versus donors after brain death. Campo-Canaveral de la Cruz J, Minambres E, Coll E, Padilla M, Antolin G, de la Rosa G, Rosado J, Gonzalez Garcia F, Crowley Carrasco S, Sales Badia G, Fieria Costa E, Garcia Salcedo J, Mora V, de la Torre C, Badenes R, Atutxa Bizkarguenaga L, Dominguez-Gil B. American Journal of Transplantation. 2023 Jul;23(7):996-1008. doi: 10.1016/j.ajt.2023.04.016. PMID: 37100392

Postoperative delirium and cognitive dysfunction after general and regional anesthesia: a systematic review and meta-analysis. Viderman D, Nabidollayeva F, Aubakirova M, Yessimova D, Badenes R, Abdildin Y. Journal of Clinical Medicine. 2023 May 18;12(10):3549. doi: 10.3390/jcm12103549. PMID: 37240655

Processed electroencephalogram-based monitoring to guide sedation in critically ill adult patients: recommendations from an international expert panel-based consensus. Rasulo F, Hopkins P, Lobo F, Pandin P, Matta B, Carozzi C, Romagnoli S, Absalom A, Badenes R, Bleck T, Caricato A, Claassen J, Denault A, Honorato C, Motta S, Meyfroidt G, Radtke F, Ricci Z, Robba C, Taccone F, Vespa P, Nardiello I, Lamperti M. Neurocritical Care. 2023 Apr;38(2):296-311. doi: 10.1007/s12028-022-01565-5. PMID: 35896766

Quality improvement in the determination of death by neurologic criteria around the world. Lewis A, Kirschen M, Badenes R. Critical Care. 2023 Mar 21;27(1):96. doi: 10.1186/s13054-023-04373-1. PMID: 36941711

Reply to Farahani, P.; Wahid, L. Comment on Viderman et al. Remote monitoring of chronic critically ill patients after hospital discharge: a systematic review. J. Clin. Med. 2022, 11, 1010. Viderman D, Seri E, Aubakirova M, Abdildin Y, Badenes R, Bilotta F. Journal of Clinical Medicine. 2023 Oct 27;12(21):6797. doi: 10.3390/jcm12216797. PMID: 37959262

Risk factors of extubation failure in neurocritical patients with the most impaired consciousness. De Courson H, Massart N, Asehnoune K, Cinotti R. Intensive Care Medicine. 2023 Oct;49(10):1251-1253. doi: 10.1007/s00134-023-07189-3. PMID: 37610483

THE MANTLE bundle for minimizing cerebral hypoxia in severe traumatic brain injury. Godoy DA, Murillo-Cabezas F, Suarez JI, Badenes R, Pelosi P, Robba C. Critical Care. 2023 Jan 12;27(1):13. doi: 10.1186/s13054-022-04242-3. PMID: 36635711

The Neurological Pupil index for outcome prognostication in people with acute brain injury (ORANGE): a prospective, observational, multicentre cohort study. Oddo M, Taccone F, Petrosino M, Badenes R, Blandino-Ortiz A, Bouzat P, Caricato A, Chesnut R, Feyling A, Ben-Hamouda N, Hemphill J, Koehn J, Rasulo F, Suarez J, Elli F, Vargiolu A, Rebora P, Galimberti S, Citerio G. The Lancet. Neurology. 2023 Oct;22(10):925-933. doi: 10.1016/S1474-4422(23)00271-5. PMID: 37652068

TRansfusion strategies in Acute brain INjured patients (TRAIN): a prospective multicenter randomized interventional trial protocol. Taccone FS, Badenes R, Bittencourt Rynkowski C, Bouzat P, Caricato A, Kurtz P, Molle K, Quintana Diaz M, Van Der Jagt M, Videtta W, Vincent JL. Trials. 2023 Jan 7;24(1):20. doi: 10.1186/s13063-022-07061-7. PMID: 36611210

Treatments for intracranial hypertension in acute brain-injured patients: grading, timing, and association with outcome. Data from the SYNAPSE-ICU study. Robba C, Graziano F, Guglielmi A, Rebora P, Galimberti S, Taccone F, Citerio G, SYNAPSE-ICU Investigators. Intensive Care Medicine. 2023 Jan;49(1):50-61. doi: 10.1007/s00134-022-06937-1. PMID: 36622462

Using optic nerve sheath diameter for Intracranial Pressure (ICP) monitoring in traumatic brain injury: a scoping review. Martínez-Palacios K, Vásquez-García S, Fariyike O, Robba C, Rubiano A. Neurocritical Care. 2023 Dec 19. doi: 10.1007/s12028-023-01884-1. PMID: 38114797

Utilization of mechanical power and associations with clinical outcomes in brain injured patients: a secondary analysis of the extubation strategies in neuro-intensive care unit patients and associations with outcome (ENIO) trial. Wahlster S, Sharma M, Taran S, Town J, Stevens R, Cinotti R, Asehoune K, Pelosi P, Robba C, ENIO Study Grp Collaborators. Critical Care. 2023 Apr 20;27(1):156. doi: 10.1186/s13054-023-04410-z. PMID: 37081474

Ventilation targets for patients undergoing mechanical thrombectomy for acute ischemic stroke: a systematic review. Scudellari A, Dudek P, Marino L, Badenes R, Bilotta F. Journal of Clinical Medicine. 2023 Jul 26;12(15):4925. doi: 10.3390/jcm12154925. PMID: 37568327

Airway management in cardiac arrest and outcomes. Author’s reply. Robba C, Battaglini D, Badenes R, Nielsen N, Pelosi P. Intensive Care Medicine. 2022 Dec;48(12):1829-1832. doi: 10.1007/s00134-022-06888-7. PMID: 36173414Arterial and Venous Cerebral Blood Flow Velocities and Their Correlation in Healthy Volunteers and Traumatic Brain Injury Patients. Cardim D, Czosnyka M, Chandrapatham K, Badenes Quiles R, Bertuccio A, Corradi F, Donnelly J, Pelosi P, Hutchinson P, Robba C. Journal of Neurosurgical Anesthesiology. 2022 Jan 1;34(1):e24-e33. doi: 10.1097/ANA.0000000000000704. PMID: 32555064

Cerebral diseases in liver transplant recipients: systematic review of clinical evidence. Dudek P, Andruszkiewicz P, Gelo R, Badenes R, Bilotta F. Journal of Clinical Medicine. 2022 Feb 13;11(4):979. doi: 10.3390/jcm11040979. PMID: 35207251

Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries. NIHR Global Health Unit on Global Surgery; COVIDSurg Collaborative. Lancet. 2022 Nov 5;400(10363):1607-1617. doi: 10.1016/S0140-6736(22)01846-3. PMID: 36328042

Excessive sedation as a risk factor for delirium: a comparison between two cohorts of ARDS critically ill patients with and without COVID-19. Rasulo F, Badenes R, Longhitano Y, Racca F, Zanza C, Marchesi M, Piva S, Beretta S, Nocivelli G, Matta B, Cunningham D, Cattaneo S, Savioli G, Franceschi F, Robba C, Latronico N. Life. 2022 Dec 5;12(12):2031. doi: 10.3390/life12122031. PMID: 36556396

Extubation in neurocritical care patients: the ENIO international prospective study. Cinotti R, Mijangos JC, Pelosi P, Haenggi M, Gurjar M, Schultz MJ, Kaye C, Godoy DA, Alvarez P, Ioakeimidou A, Ueno Y, Badenes R, Elbuzidi AAS, Piagnerelli M, Elhadi M, Reza ST, Azab MA, McCredie V, Stevens RD, Digitale JC, Fong N, Asehnoune K. Intensive Care Medicine. 2022 Nov;48(11):1539-1550. doi: 10.1007/s00134-022-06825-8. PMID: 36038713

Homocysteine plasmatic concentration in brain-injured neurocritical care patients: systematic review of clinical evidence. Lauretta M, Melotti R, Sangermano C, George A, Badenes R, Bilotta F. Journal of Clinical Medicine. 2022 Jan 13;11(2):394. doi: 10.3390/jcm11020394. PMID: 35054087

Inhaled sedation in patients with COVID-19-related acute respiratory distress syndrome: an international retrospective study. Coupet R, Schlaepfer M, Neff TA, Boucher P, Bailly P, Bellgardt M, Badenes R, Carbonell J, Becher T, Varillon C, Morand D, Blondonnet R, Constantin JM, Pereira B, O’Gara B, Jabaudon M. Journal of Clinical Medicine. 2022 Dec 20;12(1):12. doi: 10.3390/jcm12010012. PMID: 36614813

Non-invasive multimodal neuromonitoring in non-critically ill hospitalized adult patients with COVID-19: a systematic review and meta-analysis. Battaglini D, Premraj L, Huth S, Fanning J, Whitman G, Arora R, Bellapart J, Porto D, Taccone F, Suen J, Li Bassi G, Fraser J, Badenes R, Cho S, Robba C. Frontiers in Neurology. 2022 Apr 14;13:814405. doi: 10.3389/fneur.2022.814405. PMID: 35493827

Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial. Robba C, Badenes R, Battaglini D, Ball L, Sanfilippo F, Brunetti I, Jakobsen JC, Lilja G, Friberg H, Wendel-Garcia PD, Young PJ, Eastwood G, Chew MS, Unden J, Thomas M, Joannidis M, Nichol A, Lundin A, Hollenberg J, Hammon N, Saxena M, Martin A, Solar M, Taccone FS, Dankiewicz J, Nielsen N, Grejs AM, Ebner F, Pelosi P. Critical Care. 2022 Oct 21;26(1):323. doi: 10.1186/s13054-022-04186-8. PMID: 36271410

Perceptions regarding the SARS-CoV-2 pandemic’s impact on neurocritical care delivery: results from a global survey. Lele A, Wahlster S, Alunpipachathai B, Gebrewold M, Chou S, Crabtree G, English S, Der-Nigoghossian C, Gagnon D, Kim-Tenser M, Karanjia N, Kirkman M, Lamperti M, Livesay S, Mejia-Mantilla J, Melmed K, Prabhakar H, Tumino L, Rao C, Udy A, Videtta W, Moheet A. Journal of Neurosurgical Anesthesiology. 2022 Apr 1;34(2):209-220. doi: 10.1097/ANA.0000000000000825. PMID: 34882104

Remote monitoring of chronic critically ill patients after hospital discharge: a systematic review. Viderman D, Seri E, Aubakirova M, Abdildin Y, Badenes R, Bilotta F. Journal of Clinical Medicine. 2022 Feb 15;11(4):1010. doi: 10.3390/jcm11041010. PMID: 35207287

SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. COVIDSurg Collaborative, GlobalSurg Collaborative. Medical Journal of Australia. 2022 Jan;77(1):28-39. doi: 10.1111/anae.15563. PMID: 34428858

Ten rules for the management of moderate and severe traumatic brain injury during pregnancy: an expert viewpoint. Di Filippo S, Godoy D, Manca M, Paolessi C, Bilotta F, Meseguer A, Severgnini P, Pelosi P, Badenes R, Robba C. Frontiers in Neurology. 2022 Jun 9;13:911460. doi: 10.3389/fneur.2022.911460. PMID: 35756939

Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study. Rasulo F, Calza S, Robba C, Taccone F, Biasucci D, Badenes R, Piva S, Savo D, Citerio G, Dibu J, Curto F, Merciadri M, Gritti P, Fassini P, Park S, Lamperti M, Bouzat P, Malacarne P, Chieregato A, Bertuetti R, Aspide R, Cantoni A, McCredie V, Guadrini L, Latronico N. Critical Care. 2022 Apr 15;26(1):110. doi: 10.1186/s13054-022-03978-2. PMID: 35428353

Upcoming and urgent challenges in critical care research based on COVID-19 pandemic experience. Verdonk F, Feyaerts D, Badenes R, Bastarache J, Bougle A, Ely W, Gaudilliere B, Howard C, Kotfis K, Lautrette A, Le Dorze M, Mankidy B, Matthay M, Morgan C, Mazeraud A, Patel B, Pattnaik R, Reuter J, Schultz M, Sharshar T, Shrestha G, Verdonk C, Ware L, Pirracchio R, Jabaudon M. Anaesthesia, critical care & pain medicine. 2022 Jun 30;41(5):101121. doi: 10.1016/j.accpm.2022.101121. PMID: 35781076

Ventilation management and outcomes in out-of-hospital cardiac arrest: a protocol for a preplanned secondary analysis of the TTM2 trial. Robba C, Nielsen N, Dankiewicz J, Badenes R, Battaglini D, Ball L, Brunetti I, Wendel Garcia P, Young P, Eastwood G, Chew MS, Jakobsen J, Unden J, Thomas M, Joannidis M, Nichol A, Lundin A, Hollenberg J, Lilja G, Hammond NE, Saxena M, Martin A, Solar M, Taccone FS, Friberg HA, Pelosi P. BMJ Open 2022 Mar 3;12(3):e058001. doi: 10.1136/bmjopen-2021-058001. PMID: 35241476

Ventilatory settings in the initial 72h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial. Robba C, Badenes R, Battaglini D, Ball L, Brunetti I, Jakobsen J, Lilja G, Friberg H, Wendel-Garcia P, Young P, Eastwood G, Chew M, Unden J, Thomas M, Joannidis M, Nichol A, Lundin A, Hollenberg J, Hammond N, Saxena M, Annborn M, Solar M, Taccone F, Dankiewicz J, Nielsen N, Pelosi P. Intensive Care Medicine. 2022 Aug;48(8):1024-1038. doi: 10.1007/s00134-022-06756-4. PMID: 35780195

Analgesic efficacy and safety of local infiltration following lumbar decompression surgery: a systematic review of randomized controlled trials. Tsaousi G, Tsitsopoulos PP, Pourzitaki C, Palaska E, Badenes R, Bilotta F. Journal of Clinical Medicine. 2021 Dec 17;10(24):5936. doi: 10.3390/jcm10245936. PMID: 34945233Cerebral autoregulation in non-brain injured patients: a systematic review. Longhitano Y, Iannuzzi F, Bonatti G, Zanza C, Messina A, Godoy D, Dabrowski W, Li X, Czosnyka M, Pelosi P, Badenes R, Robba C. Frontiers in Neurology. 2021 Nov 16;12:732176. doi: 10.3389/fneur.2021.732176. PMID: 34899560

Changes in sub-endocardial viability ratio in traumatic brain injury patients. Siwicka-Gieroba D, Robba C, Poleszczuk J, Debowska M, Waniewski J, Badenes R, Jaroszynski A, Piasek E, Kotfis K, Biernawska J, Dabrowski W. Brain Connectivity. 2021 Jun;11(5):349-358. doi: 10.1089/brain.2020.0850. PMID: 33559521

Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study. COVIDSurg Collaborative, GlobalSurg Collaborative. Anaesthesia. 2021 Nov;76(11):1454-1464. doi: 10.1111/anae.15560. PMID: 34371522

Hemodynamic Monitoring in Patients With Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis. Simonassi F, Ball L, Badenes Quiles R, Millone M, Citerio G, Zona G, Pelosi P, Robba C. Journal of Neurosurgical Anesthesiology. 2021 Oct 1;33(4):285-292. doi: 10.1097/ANA.0000000000000679. PMID: 32011413

Hyperventilation in severe traumatic brain injury has something changed in the last decade or uncertainty continues? A Brief Review. Godoy D, Badenes R, Robba C, Cabezas F. Frontiers in Neurology. 2021 Mar 11;12:573237. doi: 10.3389/fneur.2021.573237. PMID: 33776876

Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion. Padilla M, Coll E, Fernandez-Perez C, Pont T, Ruiz A, Perez-Redondo M, Oliver E, Atutxa L, Mancino JM, Daga D, Minambres E, Moya J, Vidal B, Duenas-Jurado JM, Mosteiro F, Rodriguez-Salgado A, Fernandez-Garcia E, Lara R, Hernandez-Marrero D, Estebanez B, Rodriguez-Ferrero ML, Barber M, Garcia-Lopez F, Andres A, Santiago C, Zapatero A, Badenes R, Carrizosa F, Blanco JJ, Bernal JL, Elola FJ, Vidal C, Terron C, Castro P, Comas J, Dominguez-Gil B. American Journal of Transplantation. 2021 Nov;21(11):3618-3628. doi: 10.1111/ajt.16622. PMID: 33891793

Inhaled anesthesia in neurosurgery: still a role?. Badenes R, Nato Consolato G, Pena JD, Bilotta F. Best Practice & Research-Clinical Anaesthesiology. 2021 Jul;35(2):231-240. doi: 10.1016/j.bpa.2020.10.004. PMID: 34030807

Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study. Robba C, Graziano F, Rebora P, Elli F, Giussani C, Oddo M, Meyfroidt G, Helbok R, Taccone F, Prisco L, Vincent J, Suarez J, Stocchetti N, Citerio G, SYNAPSE-ICU Investigators. Lancet Neurology. 2021 Jul;20(7):548-558. doi: 10.1016/S1474-4422(21)00138-1. PMID: 34146513

Intranasal insulin administration to prevent delayed neurocognitive recovery and postoperative neurocognitive disorder: a narrative review. Badenes R, Qeva E, Giordano G, Romero-Garcia N, Bilotta F. International Journal of Environmental Research and Public Health. 2021 Mar 7;18(5):2681. doi: 10.3390/ijerph18052681. PMID: 33799976

Ketamine in acute phase of severe traumatic brain injury an old drug for new uses?. Godoy D, Badenes R, Pelosi P, Robba C. Critical Care. 2021 Jan 6;25(1):19. doi: 10.1186/s13054-020-03452-x. PMID: 33407737

Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol. Robba C, Citerio G, Taccone F, Galimberti S, Rebora P, Vargiolu A, Pelosi P, VENTIBRAIN Enlarged Steering Comm. BMJ Open. 2021 Aug 11;11(8):e047100. doi: 10.1136/bmjopen-2020-047100. PMID: 34380722

Outcome prognostication of acute brain injury using the neurological pupil index (ORANGE) study: protocol for a prospective, observational, multicentre, international cohort study. Oddo M, Taccone F, Galimberti S, Rebora P, Citerio G, Orange Study Group. BMJ Open. 2021 May 11;11(5):e046948. doi: 10.1136/bmjopen-2020-046948. PMID: 33980528

Perioperative management of polytrauma patients with severe traumatic brain injury undergoing emergency extracranial surgery: a narrative review. Picetti E, Rosenstein I, Balogh Z, Catena F, Taccone F, Fornaciari A, Votta D, Badenes R, Bilotta F. Journal of Clinical Medicine. 2021 Dec 21;11(1):18. doi: 10.3390/jcm11010018. PMID: 35011760

Potentially detrimental effects of hyperosmolality in patients treated for traumatic brain injury. Dabrowski W, Siwicka-Gieroba D, Robba C, Bielacz M, Solek-Pastuszka J, Kotfis K, Bohatyrewicz R, Jaroszynski A, Malbrain M, Badenes R. Journal of Clinical Medicine. 2021 Sep 14;10(18):4141. doi: 10.3390/jcm10184141. PMID: 34575255

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study. Pun B, Badenes R, Heras La Calle G, Orun O, Chen W, Raman R, Simpson B, Wilson-Linville S, Hinojal Olmedillo B, Vallejo de la Cueva A, van der Jagt M, Navarro Casado R, Leal Sanz P, Orhun G, Ferrer Gomez C, Nunez Vazquez K, Pineiro Otero P, Taccone F, Gallego Curto E, Caricato A, Woien H, Lacave G, O’Neal H, Peterson S, Brummel N, Girard T, Ely E, Pandharipande P, COVID-19 Intensive Care International Study Group. Lancet. Respiratory medicine. 2021; 9(3): 239-250. doi: 10.1016/S2213-2600(20)30552-X. PMID: 33428871

Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients during the first wave of the pandemic: observational report from 28 European intensive care units. Lavinio A, Ercole A, Battaglini D, Magnoni S, Badenes R, Taccone F, Helbok R, Thomas W, Pelosi P, Robba C. Critical Care. 2021 Apr 22;25(1):155. doi: 10.1186/s13054-021-03543-3. PMID: 33888132

Seizures and sepsis: a narrative review. Alessandri F, Badenes R, Bilotta F. Journal of Clinical Medicine. 2021 Mar 3;10(5):1041. doi: 10.3390/jcm10051041. PMID: 33802419

Suppression of electrographic seizures is associated with amelioration of QTc interval prolongation in patients with traumatic brain injury. Dabrowski W, Siwicka-Gieroba D, Schlegel TT, Robba C, Zaid S, Bielacz M, Jaroszynski A, Badenes R. Journal of Clinical Medicine. 2021 Nov 18;10(22):5374. doi: 10.3390/jcm10225374. PMID: 34830656

The effects of arterial CO 2 on the injured brain: two faces of the same coin. Godoy D, Rovegno M, Lazaridis C, Badenes Quiles R. Journal of Critical Care. 2021 Feb;61:207-215. doi: 10.1016/j.jcrc.2020.10.028. PMID: 33186827

The prone position must accommodate changes in IAP in traumatic brain injury patients. Dabrowski W, Siwicka-Gieroba D, Robba C, Badenes R, Malbrain M. Critical Care. 2021 Apr 7;25(1):132. doi: 10.1186/s13054-021-03506-8. PMID: 33827641

The role of non-invasive brain oximetry in adult critically ill patients without primary brain injury. Badenes R, Bogossian EG, Chisbert V, Robba C, Oddo M, Taccone FS, Matta BF. Minerva Anestesiologica. 2021 Nov;87(11):1226-1238. doi: 10.23736/S0375-9393.21.15333-7. PMID: 33938677

The use of different components of brain oxygenation for the assessment of cerebral haemodynamics: a prospective observational study on COVID-19 patients. Robba C, Cardim D, Ball L, Battaglini D, Dabrowski W, Bassetti M, Giacobbe D, Czosnyka M, Badenes R, Pelosi P, Matta B. Frontiers in Neurology. 2021 Dec 20;12:735469. doi: 10.3389/fneur.2021.735469. PMID: 34987461

Usefulness of cerebral oximetry in TBI by NIRS. Barud M, Dabrowski W, Siwicka-Gieroba D, Robba C, Bielacz M, Badenes R. Journal of Clinical Medicine. 2021 Jun 30;10(13):2938. doi: 10.3390/jcm10132938. PMID: 34209017

Variability in serum sodium concentration and prognostic significance in severe traumatic brain injury: a multicenter observational study. Harrois A, Anstey J, van der Jagt M, Taccone F, Udy A, Citerio G, Duranteau J, Ichai C, Badenes Quiles R, Prowle J, Ercole A, Oddo M, Schneider A, Wolf S, Helbok R, Nelson D, Cooper D, Bellomo R, TBI Collaborative. Neurocritical Care. 2021 Jun;34(3):899-907. doi: 10.1007/s12028-020-01118-8. PMID: 33009658

+ Info
Title: Delirium en pacientes críticos con infección por SARS-CoV-2
Doctoral candidate: Ferrer Gómez, Carolina
Director(s): Badenes Quiles, Rafael; De Andrés Ibáñez, José
Date of the defense: 19/11/2021
University: Universitat de València

Title: Cerebrospinal fluid glucose and lactate concentrations after traumatic brain injury
Doctoral candidate: Lozano Roig, Angels
Director(s): Badenes Quiles, Rafael; Maruenda Paulino, Armando; Taccone, Fabio Silvio
Date of the defense: 30/06/2021
University: Universitat de València