Dr. José Tomás Real Collado

Principal Investigator
Research Group on Cardiometabolic Risk and Diabetes

Presentation

Dr. José T. Real is Professor of Medicine at the University of Valencia and Head of the Endocrinology and Nutrition Service at the Hospital Clínico Universitario of Valencia. His training as a medical internal resident was carried out at the Hospital Clínico Universitario of Valencia. After completing this period, he trained in molecular biology laboratory techniques, obtaining his PhD in the field of molecular biology applied to the study of primary dyslipidemia, making an important contribution to the genetic diagnosis of familial hypercholesterolemia.

He is also coordinator of the transversal program on overweight, obesity and metabolic, vascular and renal risk at the Health Research Institute – INCLIVA, and responsible for the participation of the research group in the CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM) of the Institute of Health Charles III. His research work has been developed mainly in the area of cardiometabolic risk and diabetes and its associated complications. He is the author of more than 150 original papers and reviews published in different international journals. He has been the principal investigator in multiple research projects financed in competitive public calls, both national and regional. As a collaborator, he has also participated in European projects and national and regional competitive projects.

Dr. José Tomás Real Collado
Principal
Investigator
Dr. José Tomás Real Collado

jose.t.real@uv.es; jtreal@uv.es

Publications
CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction. Hueso L, Marques P, Morant B, Gonzalez-Navarro H, Ortega J, Real J, Sanz M, Piqueras L. Frontiers in Endocrinology. 2023 Apr 12;14:1154158. doi: 10.3389/fendo.2023.1154158. PMID: 37124725

Comparison of GLP-1 Receptor agonists and other glucose-lowering agents on cardiovascular outcomes in individuals with type 2 diabetes and obesity: a spanish real-world population-based study. Palanca A, Javier Ampudia-Blasco F, Miguel Calderon J, Sauri I, Martinez-Hervas S, Luis Trillo J, Redon J, Real J. Diabetes Research and Clinical Practice. 2023 Dec 22:111071. doi: 10.1016/j.diabres.2023.111071. PMID: 38142748

Impact of conducting a genetic study on the management of familial hypercholesterolemia. Marco-Benedi V, Cenarro A, Vila A, Real J, Tamarit J, Walther L, Diaz-Diaz J, Perea V, Civeira F, Vaz A. Journal of Clinical Lipidology. 2023 Nov-Dec;17(6):717-731. doi: 10.1016/j.jacl.2023.08.008. PMID: 37813710

Low muscle mass is associated with poorer glycemic control and higher oxidative stress in older patients with type 2 Diabetes. Alabadi B, Civera M, De la Rosa A, Martinez-Hervas S, Gomez-Cabrera M, Real J. Nutrients. 2023 Jul 17;15(14):3167. doi: 10.3390/nu15143167. PMID: 37513585

Metabolomic signature and molecular profile of normal and degenerated human intervertebral disc cells. Francisco V, Eldjoudi D, Gonzalez-Rodriguez M, Ruiz-Fernandez C, Cordero-Barreal A, Marques P, Sanz M, Real J, Lago F, Pino J, Farrag Y, Gualillo O. Spine Journal. 2023 Oct;23(10):1549-1562. doi: 10.1016/j.spinee.2023.06.005. PMID: 37339697

Real-world evaluation of GLP-1 receptor agonist therapy persistence, adherence and therapeutic inertia among obese adults with Type 2 Diabetes. Palanca A, Ampudia Blasco F, Calderon J, Sauri I, Martinez Hervas S, Trillo J, Redon J, Real J. Diabetes Therapy. 2023 Apr;14(4):723-736. doi: 10.1007/s13300-023-01382-9. PMID: 36847952

Remission of graves disease after initiation of ocrelizumab in patients with multiple sclerosis. Casany-Fernandez R, Gascon-Gimenez F, Matarredona Solaz E, Pardo Lozano F, Dominguez-Moran J, Ferri Ciscar J, Real J. Thyroid. 2023 Feb;33(2):267-269. doi: 10.1089/thy.2022.0398. PMID: 36416241

A very rare variant in SREBF2, a possible cause of hypercholesterolemia and increased glycemic levels. Garcia-Garcia A, Martinez-Hervas S, Vernia S, Ivorra C, Pulido I, Martin-Escudero J, Casado M, Carretero J, Real J, Chaves F. Biomedicines. 2022 May 19;10(5):1178. doi: 10.3390/biomedicines10051178. PMID: 35625914

Adipokines in non-alcoholic fatty liver disease: are we on the road toward new biomarkers and therapeutic targets?. Francisco V, Sanz M, Real J, Marques P, Capuozzo M, Ait Eldjoudi D, Gualillo O. Biology. 2022 Aug 19;11(8):1237. doi: 10.3390/biology11081237. PMID: 36009862

Association of chemokines IP-10/CXCL10 and I-TAC/CXCL11 with insulin resistance and enhance leukocyte endothelial arrest in obesity. Moreno B, Hueso L, Ortega R, Benito E, Martinez Hervas S, Peiro M, Civera M, Sanz MJ, Piqueras L, Real JT. Microvascular Research. 2022 Jan;139:104254. doi: 10.1016/j.mvr.2021.104254. PMID: 34534571

Beneficial effects of PCSK9 inhibition with alirocumab in familial hypercholesterolemia involve modulation of new immune players. Marques P, Domingo E, Rubio A, Martinez-Hervas S, Ascaso JF, Piqueras L, Real JT, Sanz MJ. Biomedicine & Pharmacotherapy. 2022 Jan;145:112460. doi: 10.1016/j.biopha.2021.112460. PMID: 34864314

Corticotroph cell hyperplasia as a rare cause of ACTH-dependent Cushing syndrome. Ferri J, Martinez-Ibanez J, Terradez L, Savall E, Martinez-Hervas S, Oller M, Lorente R, Ascaso J, Real J. Endocrinologia, Diabetes y Nutrición. 2022 Nov;69(9):694-701. doi: 10.1016/j.endien.2022.11.004. PMID: 36470644

Developing a simple and practical decision model to predict the risk of incident type 2 diabetes among the general population: The Di@bet.es Study. Martinez-Hervas S, Morales-Suarez-Varela MM, Andres-Blasco I, Lara-Hernandez F, Peraita-Costa I, Real JT, Garcia-Garcia AB, Chaves FJ. European Journal of Internal Medicine. 2022 Aug;102:80-87. doi: 10.1016/j.ejim.2022.05.005. PMID: 35570127

Effect of personality on blood glucose control in patients with type 1 diabetes. Gu Hong W, Ferri J, Ampudia-Blasco F, Martin-Brufau R, Peiro M, Benito E, Martinez-Hervas S, Sanz M, Real J. Endocrinologia, Diabetes y Nutricion. 2022 Nov;69(9):677-685. doi: 10.1016/j.endien.2021.11.034. PMID: 36470643

Efficacy and safety of lomitapide in homozygous familial hypercholesterolaemia: the pan-European retrospective observational study. D’Erasmo L, Steward K, Cefalu A, Di Costanzo A, Boersma E, Bini S, Arca M, van Lennep J, Real Collado J, Italian and European Working Group on Lomitapide in HoFH. European Journal of Preventive Cardiology. 2022 May 5;29(5):832-841. doi: 10.1093/eurjpc/zwab229. PMID: 34971394

Immune-mediated necrotising inflammatory myopathy. A rare side effect of statins. Alarcon Chulilla M, Avila Fuentes M, Casan Fernandez R, Muelas N, Real Collado J. Endocrinologia, Diabetes y Nutricion. 2022 Oct;69(8):648-649. doi: 10.1016/j.endien.2022.10.001. PMID: 36347793

Impact of COVID-19 lockdown on diabetes management and follow-up in a broad population in Spain. Palanca A, Quinones Torrelo C, Girbes J, Real JT, Ampudia Blasco FJ. European Journal of Clinical Investigation. 2022 Jun;52(6):e13771. doi: 10.1111/eci.13771. PMID: 35313009

SEA 2022 standards for global control of cardiovascular risk. Mostaza J, Pinto X, Armario P, Masana L, Real J, Valdivielso P, Arrobas-Velilla T, Baeza-Trinidad R, Calmarza P, Cebollada J, Civera-Andres M, Cuende Melero J, Diaz-Diaz J, Fernandez Pardo J, Guijarro C, Jerico C, Laclaustra M, Lahoz C, Lopez-Miranda J, Martinez-Hervas S, Muniz-Grijalvo O, Paramo J, Pascual V, Pedro-Botet J, Perez-Martinez P, Plana N, Puzo J, Sanchez Chaparro M, Vila L. Clinica e Investigacion en Arteriosclerosis. 2022 May-Jun;34(3):130-179. doi: 10.1016/j.arteri.2021.11.003. PMID: 35090775

The controversial role of vitamin D in thyroid cancer prevention. Palanca A, Ampudia-Blasco F, Real J. Nutrients. 2022 Jun 23;14(13):2593. doi: 10.3390/nu14132593. PMID: 35807774

Activation of the constitutive androstane receptor inhibits leukocyte adhesiveness to dysfunctional endothelium. Lopez-Riera M, Ortega R, Hueso L, Montesinos MC, Gomez-Cabrera MC, Sanz MJ, Real JT, Piqueras L. International Journal of Molecular Sciences. 2021 Aug 27;22(17):9267. doi: 10.3390/ijms22179267. PMID: 34502180

Anthropometric indicators as a tool for diagnosis of obesity and other health risk factors: a literature review. Piqueras P, Ballester A, Dura-Gil J, Martinez-Hervas S, Redon J, Real J. Frontiers in Psychology. 2021 Jul 9;12:631179. doi: 10.3389/fpsyg.2021.631179. PMID: 34305707

Frailty is associated with oxidative stress in older patients with Type 2 Diabetes. Alabadi B, Civera M, De la Rosa A, Martinez-Hervas S, Gomez-Cabrera MC, Real JT. Nutrients. 2021 Nov 9;13(11):3983. doi: 10.3390/nu13113983. PMID: 34836238

Hypercholesterolemic patients have higher eryptosis and erythrocyte adhesion to human endothelium independently of statin therapy. Cilla A, Lopez-Garcia G, Collado-Diaz V, Blanch-Ruiz MA, Garcia-Llatas G, Barbera R, Martinez-Cuesta MA, Real JT, Alvarez A, Martinez-Hervas S. International Journal of Clinical Practice. 2021 Nov;75(11):e14771. doi: 10.1111/ijcp.14771. PMID: 34473881

NT3/TrkC pathway modulates the expression of ucp-1 and adipocyte size in human and rodent adipose tissue. Bove M, Monto F, Guillem-Llobat P, Ivorra M, Noguera M, Zambrano A, Sirerol-Piquer M, Requena A, Garcia-Alonso M, Tejerina T, Real J, Farinas I, D’Ocon P. Frontiers in Endocrinology. 2021 Mar 18;12:630097. doi: 10.3389/fendo.2021.630097. PMID: 33815288

Oral unsaturated fat load impairs postprandial systemic inflammation in primary hypercholesterolemia patients. Collado A, Domingo E, Marques P, Perello E, Martínez-Hervás S, Piqueras L, Ascaso JF, Real JT, Sanz MJ. Frontiers in Pharmacology. 2021 Apr 20;12:656244. doi: 10.3389/fphar.2021.656244. PMID: 33959024

Peripheral blood levels of CXCL10 are a useful marker for diabetic polyneuropathy in subjects with type 2 diabetes. Ascaso P, Palanca A, Martinez-Hervas S, Sanz MJ, Ascaso JF, Piqueras L, Real JT. International Journal of Clinical Practice. 2021 Aug;75(8):e14302. doi: 10.1111/ijcp.14302. PMID: 33930221

Postprandial triglyceridemia is modulated by insulin resistance but not by grade of obesity in abdominal and morbid obese subjects. Moreno-Perez B, Benito E, Civera M, Alabadi B, Martinez-Hervas S, Peiro M, Gonzalez-Navarro H, Piqueras L, Jesus Sanz M, Ascaso J, Real J. International Journal of Clinical Practice. 2021 Apr;75(4):e13776. doi: 10.1111/ijcp.13776. PMID: 33089594

The nuclear retinoid-related orphan receptor RORalpha controls adipose tissue inflammation in patients with morbid obesity and diabetes. Ortega R, Hueso L, Benito E, Ortega J, Civera M, Sanz M, Real J, Piqueras L. International Journal of Obesity. 2021 Jul;45(7):1369-1381. doi: 10.1038/s41366-021-00787-5. PMID: 33637954

Therapeutic inertia in patients with type 2 diabetes treated with non-insulin agents. Ampudia-Blasco F, Palanca A, Trillo J, Navarro J, Real J. Journal of diabetes and its complications. 2021 Mar;35(3):107828. doi: 10.1016/j.jdiacomp.2020.107828. PMID: 33436143

Projects
Reference: PI21/00220
Title: Estudio de nuevos ejes de quimiocinas como potenciales dianas de intervención en la obesidad y la resistencia a la insulina
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Laura Piqueras Ruiz, José Tomas Real Collado
Duration: 2022 – 2024
Total budget: 204.490 €
Reference: PI18/00209
Title: Identificación de nuevos mecanismos implicados en la angiogénesis e inflamación en pacientes obesos. Modulación por ligandos de receptores nucleares constitutivos de androstano
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Laura Piqueras Ruiz, José Tomas Real Collado
Duration: 2019 – 2022
Total budget: 173.333 €
Reference: CB07/08/0018
Title: CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem)
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: José Tomás Real Collado
Duration: 2008 –
Total budget: 154.577 €
+ Info
Title: Estudio de la sarcopenia y la fragilidad en una población diabética de edad avanzada y su relación con parámetros de estrés oxidativo
Doctoral candidate: Alabadí Pardiñes, Blanca
Director(s): Real Collado, Jose Tomás; Civera Andrés, Miguel
Date of the defense: 11/11/2022
University: Universitat de València

Title: Effect of SGLT-2 inhibition in abdominal aortic aneurysm development. Role of rora in adipose tissue inflammation associated to obesity
Doctoral candidate: Ortega Herráiz, Rebeca
Director(s): Piqueras Ruiz, Laura; Sanz Ferrando, María Jesús; Real Collado, José Tomás
Date of the defense: 21/02/2022
University: Universitat de València

Title: Influencia de la situación postprandial sobre el eje CCL11/CCR3 en sujetos con hipercolesterolemia
Doctoral candidate: Perelló Camacho, Eva
Director(s): Ascaso Gimilio, Juan F; Real Collado, Jose Tomás
Date of the defense: 23/11/2020
University: Universitat de València

Title: Efecto de los parámetros epigenéticos tras dos años de la cirugía bariátrica
Doctoral candidate: Wu Xiong, Ning Yun
Director(s): Ascaso Gimilio, Juan F; Real Collado, Jose Tomás
Date of the defense: 22/09/2020
University: Universitat de València

Title: Identificación de variantes genéticas relacionadas con diabetes mellitus tipo 2 en población española
Doctoral candidate: Lendínez Tortajada, Verónica
Director(s): Chaves Martínez, Felipe Javier; Real Collado, Jose Tomás
Date of the defense: 31/01/2020
University: Universitat de València

Title: Metilación del ADN de adipocitos en sujetos con obesidad mórbida
Doctoral candidate: Martínez Ibáñez, Juncal
Director(s): Real Collado, Jose Tomás; Ascaso Gimilio, Juan F
Date of the defense: 22/07/2019
University: Universitat de València

Title: Lipemia postprandial y regulación génica en la obesidad mórbida
Doctoral candidate: Artero Fullana, Ana
Director(s): Real Collado, Jose Tomás; Ascaso Gimilio, Juan F
Date of the defense: 21/03/2019
University: Universitat de València