Dr. Jaime Signes-Costa Miñana

Principal Investigator
Research Group on Respiratory Diseases

Presentation

Jefe de Servicio de Neumología del Hospital Clínico Universitario de Valencia.

Licenciado en Medicina y Cirugía por la Facultad de Medicina de la Universidad de Valencia y Doctor en Medicina por la Universidad de Málaga.
Realiza la residencia en la especialidad de Neumología en el Hospital Clínico de Valencia (1991-1994). Durante su periodo formativo lleva a cabo dos estancias (“visiting professor”, “clinical observer”) en James H. Quillen College of Medicine at East Tennessee State University y MD Anderson Cancer Center Houston, University of Texas.

Ha desarrollado su labor profesional en distintos hospitales de la Comunidad Valencia hasta su incorporación en 2014 al Hospital Clínico. Actualmente es coordinador nacional de tabaquismo de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR). Ha sido presidente de las Sociedad Valenciana de Neumología (2015-2017). Académico correspondiente de la Real Academia de Medicina de la Comunidad Valenciana desde 2004.

Sus trabajos de investigación iniciales se centraron en las complicaciones pulmonares en pacientes inmunocomprometidos. Tiene publicados artículos y capítulos de libros sobre el síndrome de apneas obstructivas del sueño (SAOS) y sobre el tratamiento del tabaquismo en diferentes escenarios.

En estos momentos su especial interés son las secuelas post COVID-19 a medio y largo plazo, en concreto las alteraciones pulmonares en pacientes ingresados por neumonía bilateral por SARS-CoV-2.

Dr. Jaime Signes-Costa Miñana
Principal
Investigator
Dr. Jaime Signes-Costa Miñana

jaimesignescosta@gmail.com

Publications
Clinical Practice Guideline of Spanish Society of Pneumology and Thoracic Surgery (SEPAR) on Pharmacological Treatment of Tobacco Dependence 2023. Rabade-Castedo C, de Granda-Orive J, Riesco-Miranda J, De Higes-Martinez E, Ramos-Pinedo A, Cabrera-Cesar E, Signes-Costa Minana J, Garcia Rueda M, Pastor-Espla E, Jimenez-Ruiz C. Archivos de Bronconeumologia. 2023 Oct;59(10):651-661. doi: 10.1016/j.arbres.2023.07.024. PMID: 37567792

Clinical profile and determinants of mortality in patients with interstitial lung disease admitted for COVID-19. Mulet A, Nunez-Gil I, Carbonell J, Soriano J, Viana-Llamas M, Raposeiras-Roubin S, Romero R, Alfonso-Rodriguez E, Uribarri A, Feltes G, Becerra-Munoz V, Santoro F, Pepe M, Castro-Mejia A, Chipayo D, Corbi-Pascual M, Lopez-Pais J, Vedia O, Manzone E, Molina-Romera G, Espejo-Paeres C, Lopez-Masjuan A, Velicki L, Fernandez-Ortiz A, El-Battrawy I, Signes-Costa J, On Behalf Of Hope Team. Journal of Clinical Medicine. 2023 Jun 2;12(11):3821. doi: 10.3390/jcm12113821. PMID: 37298018

Fibrosis biomarkers in a cohort of COVID-19 Patients One Year after Hospital Discharge. Mulet A, Tarraso J, Rodriguez-Borja E, Carbonell-Asins J, Lope-Martinez A, Marti-Martinez A, Murria R, Safont B, Fernandez-Fabrellas E, Ros J, Rodriguez-Portal J, Andreu A, Soriano J, Signes-Costa J. American Journal of Respiratory Cell and Molecular Biology. 2023 Sep;69(3):321-327. doi: 10.1165/rcmb.2022-0474OC. PMID: 36848314

Frequency and characteristics of asthma in smokers attending smoking cessation units in Spain. Riesco J, Rábade C, Signes-Costa J, Cabrera E, Jimenez C. PLoS One. 2023 Dec 7;18(12):e0294587. doi: 10.1371/journal.pone.0294587. PMID: 38060490

Home noninvasive ventilation in Myasthenia Gravis. Sancho J, Ferrer S, Quezada A, Gimenez E, Signes-Costa J. Respiratory Care. 2023 Nov 7:respcare.11308. doi: 10.4187/respcare.11308. PMID: 37935525

Persistent pulmonary fibrotic sequelae in patients with telomere shortening one year after severe COVID-19. Mulet A, González-Cabo P, Pallardó FV, Signes-Costa J. Archivos de Bronconeumologia. 2023 Nov 10:S0300-2896(23)00365-4. doi: 10.1016/j.arbres.2023.11.003. PMID: 37985282

Post-COVID-19 symptoms and heart disease: incidence, prognostic factors, outcomes and vaccination: results from a multi-center international prospective registry (HOPE 2). Nunez-Gil IJ, Feltes G, Viana-Llamas MC, Raposeiras-Roubin S, Romero R, Alfonso-Rodriguez E, Uribarri A, Santoro F, Becerra-Munoz V, Pepe M, Castro-Mejia AF, Signes-Costa J, Gonzalez A, Marin F, Lopez-Pais J, Cerrato E, Vazquez-Cancela O, Espejo-Paeres C, Lopez Masjuan A, Velicki L, El-Battrawy I, Ramakrishna H, Fernandez-Ortiz A, Perez-Villacastin J. Journal of Clinical Medicine. 2023 Jan 16;12(2):706. doi: 10.3390/jcm12020706. PMID: 36675633

Stiff-person syndrome with respiratory complications. Gimenez E, Sancho J, Signes-Costa J. Archivos de Bronconeumologia. 2023 Dec 20:S0300-2896(23)00410-6. doi: 10.1016/j.arbres.2023.12.008. PMID: 38160164

The DESTINA Study: an observational cross-sectional study to evaluate patient satisfaction and tolerability of cytisine for smoking cessation in spain. Jimenez-Ruiz C, Riesco Miranda J, Martinez Pico A, de Simon Gutierrez R, Signes-Costa Minana J, Diaz Maroto Munoz J, Sellares Torres J. Archivos de Bronconeumologia. 2023 Apr;59(4):270-272. doi: 10.1016/j.arbres.2022.11.015. PMID: 36549936

Aspirin therapy on prophylactic anticoagulation for patients hospitalized with COVID-19: a propensity score-matched cohort analysis of the HOPE-COVID-19 Registry. Santoro F, Nunez-Gil I, Vitale E, Viana-Llamas M, Romero R, Eid C, Guzman G, Becerra-Munoz V, Rozas I, Uribarri A, Alfonso-Rodriguez E, Aguado M, Huang J, Mejia A, Prieto J, Elola J, Ugo F, Cerrato E, Signes-Costa J, Roubin S, Mendez J, Paeres C, Masjuan A, Marin F, Guerra F, El-Battrawy I, Cortese B, Ramakrishna H, Perez-Villacastin J, Fernandez-Ortiz A, Brunetti N. Journal of the American Heart Association. 2022 Jul 5;11(13):e024530. doi: 10.1161/JAHA.121.024530. PMID: 35730631

Chronic oral anticoagulation therapy and prognosis of patients admitted to hospital for COVID-19: insights from the HOPE COVID-19 Registry. Rivera-Caravaca J, Nunez-Gil I, Lip G, Uribarri A, Viana-Llamas M, Gonzalez A, Castro-Mejia A, Gonzalez B, Alfonso E, Prieto J, Cavallino C, Cortese B, Feltes G, Fernandez-Rozas I, Signes-Costa J, Huang J, Aguado M, Pepe M, Romero R, Cerrato E, Becerra-Munoz V, Roubin S, Santoro F, Bagur R, Sposato L, El-Battrawy I, Masjuan A, Fernandez-Ortiz A, Estrada V, Macaya C, Marin F. International Journal of Clinical Practice. 2022 May 26;2022:7325060. doi: 10.1155/2022/7325060. PMID: 35685504

Idiopathic pulmonary fibrosis and telomeres. Mulet A, Signes-Costa J. Journal of Clinical Medicine. 2022 Nov 22;11(23):6893. doi: 10.3390/jcm11236893. PMID: 36498467

Initial SARS-CoV-2 RNA load in nasopharyngeal specimens is not associated with severity and midterm resolution of pneumonia in COVID-19 patients. Costa R, Signes-Costa J, Olea B, Tarraso J, Carbonell N, Blasco M, Navarro D. Journal of Infection. 2022 Dec;85(6):702-769. doi: 10.1016/j.jinf.2022.10.031. PMID: 36346264

Las unidades de deshabituacion tabaquica como oportunidad para el diagnostico de EPOC: el proyecto 1000-200. Lopez-Campos JL, Jimenez-Ruiz CA, Meneses Petersen ED, Rabade Castedo C, Asensio Sanchez S, Vaquero Lozano P, Ferrer Espinosa S, Perez Soriano MP, de Higes Martinez E, Garcia de Llanos C, Pastor Espla E, Cabrera Cesar E, Mogrovejo S, Riesco Miranda JA, Barrueco Ferrero M, Callejas Gonzalez FJ, Sandoval Contreras R, Pena Miguel T, Peris Cardells R, Gonzalez Dou MV, Guzman Aguilar JM, Amado CA, Gorordo Unzueta MI, Rois Seijas P, Martinez Muniz MA, Naval Sendra E, Granda-Orive JI, Signes-Costa J. Archivos de Bronconeumologia. 2022 Mar;58(3):264-267. doi: 10.1016/j.arbres.2021.05.013. PMID: 34158184

Lung fibrosis and fibrosis in the lungs: is it all about myofibroblasts?. Ortiz-Zapater E, Signes-Costa J, Montero P, Roger I. Biomedicines. 2022 Jun 15;10(6):1423. doi: 10.3390/biomedicines10061423. PMID: 35740444

Lung function, radiological findings and biomarkers of fibrogenesis in a cohort of COVID-19 patients six months after hospital discharge. Safont B, Tarraso J, Rodriguez-Borja E, Fernandez-Fabrellas E, Sancho-Chust JN, Molina V, Lopez-Ramirez C, Lope-Martinez A, Cabanes L, Andreu A, Herrera S, Lahosa C, Ros JA, Rodriguez-Hermosa JL, Soriano JB, Moret-Tatay I, Carbonell-Asins JA, Mulet A, Signes-Costa J. Archivos de Bronconeumologia. 2022 Feb;58(2):142-149. doi: 10.1016/j.arbres.2021.08.014. PMID: 34497426

Smoking cessation units as a source of COPD diagnoses: Project 1000-200. Lopez-Campos J, Jimenez-Ruiz C, Meneses Petersen E, Rabade Castedo C, Asensio Sanchez S, Vaquero Lozano P, Ferrer Espinosa S, Perez Soriano M, de Higes Martinez E, Garcia de Llanos C, Pastor Espla E, Cabrera Cesar E, Mogrovejo S, Riesco Miranda J, Barrueco Ferrero M, Callejas Gonzalez F, Sandoval Contreras R, Pena Miguel T, Peris Cardells R, Gonzalez Dou M, Guzman Aguilar J, Amado C, Gorordo Unzueta M, Rois Seijas P, Martinez Muniz M, Naval Sendra E, Granda-Orive J, Signes-Costa J. Archivos de Bronconeumología. 2022 Mar;58(3):T264-T267. doi: 10.1016/j.arbres.2021.05.031. PMID: 35312495

The radiographic assessment of lung edema score of lung edema severity correlates with inflammatory parameters in patients with coronavirus disease 2019-Potential new admission biomarkers to predict coronavirus disease 2019 worsening. Marques P, Fernandez-Presa L, Carretero A, Gómez-Cabrera MC, Viña J, Signes-Costa J, Sanz MJ. Frontiers in Medicine. 2022 Aug 11;9:871714. doi: 10.3389/fmed.2022.871714. PMID: 36035415

Waveforms analysis in patients with amyotrophic lateral sclerosis for enhanced efficacy of mechanically assisted coughing. Sancho J, Ferrer S, Bures E, Fernandez-Presa L, Banuls P, Gonzalez MC, Signes-Costa J. Respiratory Care. 2022 Oct;67(10):1226-1235. doi: 10.4187/respcare.09978. PMID: 35790394

COVID-19 and the impact of arterial hypertension-An analysis of the international HOPE COVID-19 Registry (Italy-Spain-Germany). El-Battrawy I, Nunez-Gil I, Abumayyaleh M, Estrada V, Becerra-Munoz V, Uribarri A, Fernandez-Rozas I, Feltes G, Arroyo-Espliguero R, Trabattoni D, Lopez-Pais J, Pepe M, Romero R, Castro-Mejia A, Cerrato E, Astrua T, D’Ascenzo F, Fabregat-Andres O, Signes-Costa J, Marin F, Buonsenso D, Bardaji A, Tellez M, Fernandez-Ortiz A, Macaya C, Akin I. European Journal of Clinical Investigation. 2021 Aug 19;e13582. doi: 10.1111/eci.13582. PMID: 34409593

Effect of one-year dextromethorphan/quinidine treatment on management of respiratory impairment in amyotrophic lateral sclerosis. Sancho J, Ferrer S, Bures E, Diaz JL, Torrecilla T, Signes-Costa J, Servera E. Respiratory Medicine. 2021 Jul 7;186:106536. doi: 10.1016/j.rmed.2021.106536. PMID: 34260979

Healthcare professionals and tobacco industry: making the space. Jimenez-Ruiz C, Signes-Costa Minana J, Garcia Rueda M. Archivos de Bronconeumologia. 2021 Apr 15;S0300-2896(21)00120-4. doi: 10.1016/j.arbres.2021.04.002. PMID: 33958233

Mechanical Insufflation-Exsufflation With Oscillations in Amyotrophic Lateral Sclerosis With Home Ventilation via Tracheostomy. Sancho Chinesta J, Bures Sales E, Ferrer Espinosa S, Lahosa Córdoba C, Signes-Costa Miñana J, Servera Pieras E. Respiratory Care. 2021 Mar;66(3):378-383. doi: 10.4187/respcare.08145. PMID: 33082217

Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry. Nunez-Gil I, Fernandez-Perez C, Estrada V, Becerra-Munoz V, El-Battrawy I, Uribarri A, Fernandez-Rozas I, Feltes G, Viana-Llamas M, Trabattoni D, Lopez-Pais J, Pepe M, Romero R, Castro-Mejia A, Cerrato E, Astrua T, D’Ascenzo F, Fabregat-Andres O, Moreu J, Guerra F, Signes-Costa Miñana J, Marin F, Buosenso D, Bardaji A, Raposeiras-Roubin S, Elola J, Molino A, Gomez-Doblas J, Abumayyaleh M, Aparisi A, Molina M, Guerri A, Arroyo-Espliguero R, Assanelli E, Mapelli M, Garcia-Acuna J, Brindicci G, Manzone E, Ortega-Armas M, Bianco M, Trung C, Nunez M, Castellanos-Lluch C, Garcia-Vazquez E, Cabello-Clotet N, Jamhour-Chelh K, Tellez M, Fernandez-Ortiz A, Macaya C, HOPE COVID-19 Investigators. Internal and Emergency Medicine. 2021 Jun;16(4):957-966. doi: 10.1007/s11739-020-02543-5. PMID: 33165755

Prevalence and 30-Day Mortality in Hospitalized Patients With Covid-19 and Prior Lung Diseases. Signes-Costa J, Nunez-Gil I, Soriano J, Arroyo-Espliguero R, Eid C, Romero R, Uribarri A, Fernandez-Rozas I, Aguado M, Becerra-Munoz V, Huang J, Pepe M, Cerrato E, Raposeiras S, Gonzalez A, Franco-Leon F, Wang L, Alfonso E, Ugo F, Garcia-Prieto J, Feltes G, Abumayyaleh M, Espejo-Paeres C, Jativa J, Masjuan A, Macaya C, Carbonell Asins J, Estrada V, HOPE COVID-19 investigators. Archivos de Bronconeumologia. 2021 Apr;57:13-20. doi: 10.1016/j.arbres.2020.11.012. PMID: 33423874

ROX index as predictor of high flow nasal cannula therapy success in acute respiratory failure due to SARS-CoV-2. Ferrer S, Sancho J, Bocigas I, Bures E, Mora H, Monclou E, Mulet A, Quezada A, Royo P, Signes-Costa J. Respiratory Medicine. 2021 Oct 6;189:106638. doi: 10.1016/j.rmed.2021.106638. PMID: 34634500

SARS-CoV-2-reactive interferon-gamma-producing CD8+ T cells in patients hospitalized with Coronavirus Disease 2019. Gimenez Quiles E, Albert Vicent E, Torres Fink I, Remigia Pellicer M, Alcaráz Soriana M, Galindo Puerto M, Blasco Cortes M, Solano Vercet C, Forner Giner M, Redón Mas J, Signes-Costa Miñana J, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):375-382. doi: 10.1002/jmv.26213. PMID: 32579268

Tracheostomy in patients with COVID-19: predictors and clinical features. Sancho J, Ferrer S, Lahosa C, Posadas T, Bures E, Banuls P, Fernandez-Presa L, Royo P, Blasco M, Signes-Costa J. European Archives of Oto-Rhino-Laryngology. 2021 Oct;278(10):3911-3919. doi: 10.1007/s00405-020-06555-x. PMID: 33386436

Underlying heart diseases and acute COVID-19 outcomes. Abraham W, Lindenfeld J, Ponikowski P, Agostoni P, Butler J, Desai A, Filippatos G, Gniot J, Fu M, Gullestad L, Howlett J, Nicholls S, Redon J, Schenkenberger I, Silva-Cardoso J, Stork S, Krzysztof Wranicz J, Savarese G, Brueckmann M, Jamal W, Nordaby M, Peil B, Ritter I, Ustyugova A, Zeller C, Salsali A, Anker S. European Heart Journal. 2021;28(2):202-214. doi: 10.5603/CJ.a2020.0183. PMID: 33346365

Projects
Reference: COV20/01209
Title: Cambios en los test de función pulmonar en pacientes con neumonia por CoVid19
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Jaime Signes-Costa
Duration: 2020 – 2021
Total budget: 73.500 €
+ Info
Clinical Practice Guideline of Spanish Society of Pneumology and Thoracic Surgery (SEPAR) on Pharmacological Treatment of Tobacco Dependence 2023. Rabade-Castedo C, de Granda-Orive J, Riesco-Miranda J, De Higes-Martinez E, Ramos-Pinedo A, Cabrera-Cesar E, Signes-Costa Minana J, Garcia Rueda M, Pastor-Espla E, Jimenez-Ruiz C. Archivos de Bronconeumologia. 2023 Oct;59(10):651-661. doi: 10.1016/j.arbres.2023.07.024. PMID: 37567792