Dr. Clara Bonanad Lozano
Emerging Investigator
Group on Translational Research in Ischemic Heart Disease
Presentation
After finishing her specialty in Cardiology, PhD. Clara Bonanad received a Rio Hortega contract to expand her research training. This allowed her to combine an active care activity, based on the care of patients with acute coronary syndrome, with training in clinical and translational research, developing her doctoral thesis on the prognostic impact of geriatric syndromes in patients with acute coronary syndrome, obtaining the distinction “cum laude”.
She has completed a Master’s Degree in Advances in Cardiology and a Master’s Degree in Acute Cardiac Care. She has been the principal investigator of several clinical trials in the field of cardiovascular risk in patients with high-risk acute coronary syndrome (SOLIST, SCORED, THEMIS trial) as well as two competitive projects focused on translational research related to acute myocardial infarction: a Project for Emerging Groups of the Generalitat Valenciana (File GV/2018/116) and a FIS project of the Carlos III Health Institute (PI20/00637). All of this has allowed her to initiate a line of research focused on studying the impact of geriatric syndromes and residual cardiovascular risk, specifically dyslipidemia and inflammation, in patients with non-ST-segment elevation acute coronary syndrome. During her time as a researcher at this institution, she has collaborated in the publication of 86 articles in high-impact journals (D1 and Q1), as well as more than 30 communications in congresses and is directing 4 Doctoral Theses.
She is currently Associate Professor of the Department of Medicine of the University of Valencia, specifically she belongs to the faculty responsible for simulation practices and has directed 4 TFG of the Degree in Medicine. In addition, she has been President of the Geriatric Cardiology section of the Spanish Society of Cardiology as well as a member of the board of directors of the Group of Young Cardiologists and a member of the Ischemic Heart Disease section of the Valencian Society of Cardiology.
Publications
Clinical predictors and prognosis of Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) without ST-Segment elevation in older adults. Gabaldon Perez A, Bonanad C, Garcia Blas S, Marcos Garces V, Gonzalez D’Gregorio J, Fernandez Cisnal A, Valero E, Minana G, Merenciano Gonzalez H, Mollar A, Bodi V, Nunez J, Sanchis J. Journal of Clinical Medicine. 2023 Feb 2;12(3):1181. doi: 10.3390/jcm12031181. PMID: 36769828
Consensus document on palliative care in cardiorenal patients. Bonanad C, Buades J, Leiva J, de la Espriella R, Marcos M, Núñez J, García-Llana H, Facila L, Sánchez R, Rodríguez-Osorio L, Alonso-Babarro A, Quiroga B, Berroteran D, Rodríguez C, Maidana D, Díez J. Frontiers in Cardiovascular Medicine. 2023 Dec 19:10:1225823. doi: 10.3389/fcvm.2023.1225823. PMID: 38179502
Extended use of dual antiplatelet therapy among older adults with acute coronary syndromes and associated variables: a cohort study. Ariza Sole A, Mateus Porta G, Formiga F, Garcia Blas S, Bonanad C, Nunez Gil I, Vergara Uzcategui C, Diez Villanueva P, Baneras J, Badia Molins C, Aboal J, Carreras-Mora J, Gabaldon Perez A, Parada Barcia J, Martinez Selles M, Comin Colet J, Raposeiras Roubin S. Thrombosis Journal. 2023 Mar 21;21(1):32. doi: 10.1186/s12959-023-00476-5. PMID: 36944967
Impact of persistent microvascular obstruction late after STEMI on AdverseLV remodeling: a CMR Study. Bodi V, Gavara J, Lopez-Lereu M, Monmeneu J, de Dios E, Perez-Sole N, Bonanad C, Marcos-Garces V, Canoves J, Minana G, Nunez J, Moratal D, Chorro F, Rodriguez-Palomares J, Freixa A, Borras R, Ortiz-Perez J, Rios-Navarro C. JACC. Cardiovascular Imaging. 2023 Jul;16(7):919-930. doi: 10.1016/j.jcmg.2023.01.021. PMID: 37052556
Applicability of echocardiographic strict negative criteria for suspected infective endocarditis. Marcos-Garces V, Gabaldon-Perez A, Merenciano-Gonzalez H, Soler M, Lorenzo-Hernandez M, Nunez-Marin G, de la Espriella R, Bonanad C, Nunez J, Chorro FJ, Bodi V, Santas E. American Journal of Cardiology. 2022 Jan 1;162:156-162. doi: 10.1016/j.amjcard.2021.09.012. PMID: 34728063
Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure. de la Espriella R, Amiguet M, Minana G, Rodriguez JC, Moyano P, Segarra D, Fernandez J, Santas E, Nunez G, Lorenzo M, Bonanad C, Alania E, Valle A, Sanchis J, Bodi V, Gorriz JL, Navarro J, Codina P, Voors AA, Bayes-Genis A, Nunez J. European Journal of Heart Failure. 2022 Nov;24(11):2108-2117. doi: 10.1002/ejhf.2651. PMID: 36054502
Cardiovascular prevention in elderly patients. Bonanad C, Fernandez-Olmo R, Garcia-Blas S, Alarcon J, Diez-Villanueva P, Mansilla C, Garcia-Pardo H, Toledo P, Ayesta A, Pereira E, Carol A, Castro-Conde A, de Pablo-Zarzoso C, Martinez-Selles M, Arrarte V, Campuzano R, Ariza-Sole A. Journal of Geriatric Cardiology. 2022 May 28;19(5):377-392. doi: 10.11909/j.issn.1671-5411.2022.05.004. PMID: 35722032
Combined assessment of stress cardiovascular magnetic resonance and angiography to predict the effect of revascularization in chronic coronary syndrome patients. Gavara J, Perez N, Marcos-Garces V, Monmeneu J, Lopez-Lereu M, Rios-Navarro C, de Dios E, Bonanad C, Canoves J, Moratal D, Palau P, Minana G, Nunez J, Chorro F, Bodi V. European Journal of Preventive Cardiology. 2022 Mar 11;29(2):407-416. doi: 10.1093/eurjpc/zwab170. PMID: 34686874
CA125 but not NT-proBNP predicts the presence of a congestive intrarenal venous flow in patients with acute heart failure. Nunez-Marin G, de la Espriella R, Santas E, Lorenzo M, Minana G, Nunez E, Bodi V, Gonzalez M, Gorriz J, Bonanad C, Sanchis J, Bayes-Genis A, Nunez J. European Heart Journal-Acute Cardiovascular Care. 2021 Jun 30;10(5):475-483. doi: 10.1093/ehjacc/zuab022. PMID: 33829233
Direct oral anticoagulants versus warfarin in octogenarians with nonvalvular atrial fibrillation: a systematic review and meta-analysis. Bonanad C, Garcia-Blas S, Torres Llergo J, Fernandez-Olmo R, Diez-Villanueva P, Ariza-Sole A, Martinez-Selles M, Raposeiras S, Ayesta A, Bertomeu-Gonzalez V, Tarazona Santabalbina F, Facila L, Vivas D, Gabaldon-Perez A, Bodi V, Nunez J, Cordero A. Journal of Clinical Medicine. 2021 Nov 12;10(22):5268. doi: 10.3390/jcm10225268. PMID: 34830548
Frailty scales for prognosis assessment of older adult patients after acute myocardial infarction. Garcia-Blas S, Bonanad C, Fernandez-Cisnal A, Sastre-Arbona C, Ruescas-Nicolau M, D’Gregorio J, Valero E, Minana G, Palau P, Tarazona-Santabalbina F, Ros V, Nunez J, Sanchis J. Journal of Clinical Medicine. 2021 Sep 21;10(18):4278. doi: 10.3390/jcm10184278. PMID: 34575389
Long-term outcome of patients with NSTEMI and nonobstructive coronary arteries by different angiographic subtypes. Garcia-Blas S, Gonzalez D’ Gregorio J, Bonanad C, Fernandez-Cisnal A, Valero E, Minana G, Mollar A, Nunez J, Sanchis J. Revista Espanola de Cardiologia. 2021 Nov;74(11):919-926. doi: 10.1016/j.rec.2020.10.008. PMID: 33349589
Projects
Title: Resonancia magnética cardíaca de estrés con vasodilatadores para predecir la mortalidad a largo plazo en un amplio registro retrospectivo de pacientes con cardiopatía isquémica conocida o sospechada
Funding body: Sociedad Española de Cardiología
Principal Investigator: Vicent Bodí Peris
Duration: 2021 – 2022
Total budget: 15.000 €
Title: Resolución de la obstrucción microvascular tras un infartodemiocardio: evaluación de las consecuencias estructurales y clínicas y búsqueda de nuevas opciones terapéuticas
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Vicent Bodí Peris, Clara Bonanad Lozano
Duration: 2021 – 2023
Total budget: 129.470 €
Title: Estudio multidisciplinar de la dinámica, mecanismos básicos, diagnóstico y exploración de nuevas oportunidades terapéuticas en la obstrucción microvascular tras infarto agudo de miocardio
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Clara Bonanad Lozano
Duration: 2018 – 2019
Total budget: 15.000 €