Dr. Mª Jesús Sanz Ferrando
Principal Investigator
Research Group on Inflammation
Presentation
Dr. Sanz is Full Professor at the Department of Pharmacology, University of Valencia since 2009 and coordinator of the Inflammation Group at the Institute of Health Research of the University Clinic Hospital of Valencia (INCLIVA). She has been the President of the Spanish Society of Pharmacology (2014- 2019) and since June 2022, she is the President elect of the Federation of European Pharmacological Societies (EPHAR).
Since 1992 her research has been focused in the area of Immunity and Inflammation mainly on the study of the molecular and cellular mechanisms involved in endothelial dysfunction. Nowadays, her group is evaluating the impact of the systemic inflammation associated to different diseases (primary hypercholestetolemia, metabolic syndrome, nonalcoholic fatty liver disease, COPD or menopause) in the development of further cardiovascular disorders (CVD) such as atherosclerosis or abdominal aortic aneurysm. This traslational research has allowed to find new potential biomarkers of CVD and/or new therapeutic interventions to prevent it.
She has been evaluator of the Spanish National Evaluation Agency (ANEP) and other regional agencies. Consequently, she became adjunct to the Coordinator of ANEP (Spanish Ministry of Innovation and Competitiveness) from 2009 to 2013 and from 2018- 2021 she was collaborator of the Spanish Research Council (AEI). She has also evaluated international projects for different agencies (Horizon 2020, Welcome Trust or the Canadian Foundation for Innovation, among others).
As result of her research, she has published around 142 original articles and reviews in relevant peer-reviewed journals and 8 book chapters. 70% of the indexed publications are published in Q1 journals (40% of them in D1 journals). Her h-index is 41. She has supervised 17 PhD students and has been continuously funded as a PI in competitive national and regional grants since 1999. She has been invited as speaker in several international and national forums. During her research career, she did several stays abroad: NHLI, Imperial College, London, UK (3 years) and Calvin, Phoebe & Joan Snyder Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, Canada (2years). From January 2023 she is editor of the European Journal of Pharmacology.
Publications
CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction. Hueso L, Marques P, Morant B, Gonzalez-Navarro H, Ortega J, Real J, Sanz M, Piqueras L. Frontiers in Endocrinology. 2023 Apr 12;14:1154158. doi: 10.3389/fendo.2023.1154158. PMID: 37124725
Metabolomic signature and molecular profile of normal and degenerated human intervertebral disc cells. Francisco V, Eldjoudi D, Gonzalez-Rodriguez M, Ruiz-Fernandez C, Cordero-Barreal A, Marques P, Sanz M, Real J, Lago F, Pino J, Farrag Y, Gualillo O. Spine Journal. 2023 Oct;23(10):1549-1562. doi: 10.1016/j.spinee.2023.06.005. PMID: 37339697
Overview of cellular and soluble mediators in systemic inflammation associated with non-alcoholic fatty liver disease. Marques P, Francisco V, Martinez-Arenas L, Carvalho-Gomes A, Domingo E, Piqueras L, Berenguer M, Sanz M. International Journal of Molecular Sciences. 2023 Jan 24;24(3):2313. doi: 10.3390/ijms24032313. PMID: 36768637
Association of chemokines IP-10/CXCL10 and I-TAC/CXCL11 with insulin resistance and enhance leukocyte endothelial arrest in obesity. Moreno B, Hueso L, Ortega R, Benito E, Martinez Hervas S, Peiro M, Civera M, Sanz MJ, Piqueras L, Real JT. Microvascular Research. 2022 Jan;139:104254. doi: 10.1016/j.mvr.2021.104254. PMID: 34534571
Beneficial effects of PCSK9 inhibition with alirocumab in familial hypercholesterolemia involve modulation of new immune players. Marques P, Domingo E, Rubio A, Martinez-Hervas S, Ascaso JF, Piqueras L, Real JT, Sanz MJ. Biomedicine & Pharmacotherapy. 2022 Jan;145:112460. doi: 10.1016/j.biopha.2021.112460. PMID: 34864314
Correction: L-selectin regulates human neutrophil transendothelial migration. Rahman I, Sánchez AC, Davies J, Rzeniewicz K, Abukscem S, Joachim J, Hoskins Green HL, Killock D, Sanz MJ, Charras G, Parsons M, Ivetic A. Journal of Cell Science. 2022 Oct 15;135(20):jcs260658. doi: 10.1242/jcs.260658. PMID: 36259426
Effect of personality on blood glucose control in patients with type 1 diabetes. Gu Hong W, Ferri J, Ampudia-Blasco F, Martin-Brufau R, Peiro M, Benito E, Martinez-Hervas S, Sanz M, Real J. Endocrinologia, Diabetes y Nutricion. 2022 Nov;69(9):677-685. doi: 10.1016/j.endien.2021.11.034. PMID: 36470643
An updated overview of e-cigarette impact on human health. Marques P, Piqueras L, Sanz MJ. Respiratory Research. 2021 May 18;22(1):151. doi: 10.1186/s12931-021-01737-5. PMID: 34006276
L-selectin regulates human neutrophil transendothelial migration. Rahman I, Collado Sanchez A, Davies J, Rzeniewicz K, Abukscem S, Joachim J, Hoskins Green H, Killock D, Sanz M, Charras G, Parsons M, Ivetic A. Journal of Cell Science. 2021 Feb 8;134(3):jcs250340. doi: 10.1242/jcs.250340. PMID: 33408247
Oral unsaturated fat load impairs postprandial systemic inflammation in primary hypercholesterolemia patients. Collado A, Domingo E, Marques P, Perello E, Martínez-Hervás S, Piqueras L, Ascaso JF, Real JT, Sanz MJ. Frontiers in Pharmacology. 2021 Apr 20;12:656244. doi: 10.3389/fphar.2021.656244. PMID: 33959024
Peripheral blood levels of CXCL10 are a useful marker for diabetic polyneuropathy in subjects with type 2 diabetes. Ascaso P, Palanca A, Martinez-Hervas S, Sanz MJ, Ascaso JF, Piqueras L, Real JT. International Journal of Clinical Practice. 2021 Aug;75(8):e14302. doi: 10.1111/ijcp.14302. PMID: 33930221
Projects
Title: Modulación de la inflamación metabólica en la prevención de la patología cardiovascular: Identificación de nuevas dianas terapéuticas y desarrollo de fármacos novedosos.
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Mª Jesús Sanz Ferrando
Duration: 2021 – 2024
Total budget: 290.400 €
Title: Una aproximación traslacional desde la clínica a la experimentación animal: Estudio del papel del eje CCL11/CCR3 y la inflamación eosinofílica en la patología cardiovascular asociada a desórdenes metabólicos
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Mª Jesús Sanz Ferrando
Duration: 2020 – 2023
Total budget: 211.736 €
Title: Modulación farmacológica del sistema inmune como diana clave en la prevención de la enfermedad cardiovascular asociada a desordenes metabólicos. Síntesis de fármacos novedosos
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: Mª Jesús Sanz Ferrando, Juan F. Ascaso Gimilio
Duration: 2018 – 2021
Total budget: 205.700 €
Title: The William Harvey International Translational Research Academy (WHRI-ACADEMY)
Funding body: European Commission. FP7 Marie Curie Actions
Principal Investigator: Márta Korbonits
Duration: 2015 – FALTA
Total budget: 6,5 million €
+ Info
Doctoral candidate: Hueso Soler, Luisa María
Director(s): Piqueras Ruiz, Laura; Real Collado, Jose Tomás; Sanz Ferrando, María Jesús
Date of the defense: 28/04/2023
University: Universitat de València
Title: Effect of SGLT-2 inhibition in abdominal aortic aneurysm development. Role of rora in adipose tissue inflammation associated to obesity
Doctoral candidate: Ortega Herráiz, Rebeca
Director(s): Piqueras Ruiz, Laura; Sanz Ferrando, María Jesús; Real Collado, José Tomás
Date of the defense: 21/02/2022
University: Universitat de València
Title: Chemokine axes and inflammatory status in metabolic syndrome. Effect of pcsk9 inhibitors in the systemic inflammation associated to familial hypercholesterolemia
Doctoral candidate: Gomes Marques, Patrice
Director(s): Piqueras Ruiz, Laura; Sanz Ferrando, María Jesús
Date of the defense: 07/02/2020
University: Universitat de València
Title: Study of the systemic inflammation associated to primary hypercholesterolemia, its modulation and its impact in atherosclerosis. Role of cxcl16/cxcr6 axis in abdominal aortic aneurysm formation
Doctoral candidate: Collado Sánchez, Aida
Director(s): Sanz Ferrando, María Jesús; Piqueras Ruiz, Laura
Date of the defense: 22/07/2019
University: Universitat de València