Research Group on Healthy Aging (MiniAging)
Metabolism and Organic Damage Area
To know the molecular mechanisms involved in aging and frailty processes
To develop possible biomarkers to evaluate them
To develop possible methods to evaluate them
To develop appropriate intervention strategies
To determine an index of quality of life in experimental animals
To develop human imaging biomarkers for the diagnosis of frailty
To study interventions to delay aging and prevent frailty
– Therapy with small extracellular vesicles
– Role of the antiapoptotic gene Bcl-xL
Coordinator
STAFF
Collaborating Researchers
Nurse
Technicians
Administrative assistant
Publications
Effects of a low-pressure hyperbaric oxygen therapy on psychological constructs related to pain and quality of life in women with fibromyalgia: A randomized clinical trial. Izquierdo-Alventosa R, Ingles M, Cortes-Amador S, Munoz-Gomez E, Molla-Casanova S, Gimeno-Mallench L, Chrivella-Garrido J, Serra-Ano P. Medicina Clinica. 2024 Feb 20:S0025-7753(24)00033-2. doi: 10.1016/j.medcli.2023.12.016. PMID: 38383268Effects of an oral stimulation program on feeding outcomes in preterm infants: a systematic review and meta-analysis. Munoz-Gomez E, Ingles M, Molla-Casanova S, Sempere-Rubio N, Serra-Ano P, Aguilar-Rodriguez M. Physical & Occupational Therapy in Pediatrics. 2024;44(1):110-127. doi: 10.1080/01942638.2023.2212767. PMID: 37203152
Effects of mirror neuron activation therapies on functionality in older adults: systematic review and meta-analysis. Molla-Casanova S, Page A, Lopez-Pascual J, Ingles M, Sempere-Rubio N, Aguilar-Rodriguez M, Munoz-Gomez E, Serra-Ano P. Geriatric Nursing. 2024 Feb 10:56:115-123. doi: 10.1016/j.gerinurse.2024.02.006. PMID: 38346365
Altered lipid moieties and carbonyls in a wistar rat dietary model of subclinical fatty liver: potential sex-specific biomarkers of early fatty liver disease?. Martín-Grau M, Pardo-Tendero M, Casanova P, Dromant M, Marrachelli V, Morales J, Borrás C, Pisoni S, Maestrini S, Di Blasio A, Monleon D. Antioxidants. 2023 Sep 28;12(10):1808. doi: 10.3390/antiox12101808. PMID: 37891887Assessment and risk prediction of frailty using texture-based muscle ultrasound image analysis and machine learning techniques. Miron-Mombiela R, Ruiz-Espana S, Moratal D, Borras C. Mechanisms of Ageing and Development. 2023 Sep 4;215:111860. doi: 10.1016/j.mad.2023.111860. PMID: 37666473
Changes in the extracellular matrix at microvascular obstruction area after reperfused myocardial infarction: A morphometric study. Blazquez-Bujeda A, Ortega M, de Dios E, Gavara J, Perez-Sole N, Molina-Garcia T, Marcos-Garces V, Diaz A, Chorro F, Rios-Navarro C, Bodi V, Ruiz-Sauri A. Annals of Anatomy-Anatomischer Anzeiger. 2023 Jul 26;250:152138. doi: 10.1016/j.aanat.2023.152138. PMID: 37506775
Effect of non-specific neck pain on the path of the instantaneous axis of rotation of the neck during its flexion-extension movement. Page A, Ingles M, Venegas W, Molla-Casanova S, Serra-Ano P. Musculoskeletal Science & Practice. 2023 Feb 28;64:102737. doi: 10.1016/j.msksp.2023.102737. PMID: 36871441
Effect of virtual running with exercise on functionality in pre-frail and frail elderly people: randomized clinical trial. Molla-Casanova S, Munoz-Gomez E, Sempere-Rubio N, Ingles M, Aguilar-Rodriguez M, Page A, Lopez-Pascual J, Serra-Ano P. Aging Clinical and Experimental Research. 2023 Jul;35(7):1459-1467. doi: 10.1007/s40520-023-02414-x. PMID: 37188994
Author response to Ilgen, U. Alventosa R, Ingles M, Amador S, Mallench L, Rubio N, Ano P. Physical Therapy. 2022 Aug 4;102(8):pzac072. doi: 10.1093/ptj/pzac072. PMID: 35713527Blood DNA methylation patterns in older adults with evolving dementia. Fernandez Perez R, Alba Linares JJ, Tejedor JR, Fernandez Fernandez A, Calero M, Roman Dominguez A, Borras C, Vina J, Avila J, Medina M, Fernandez Fraga M. The journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Sep 1;77(9):1743-1749. doi: 10.1093/gerona/glac068. PMID: 35299244
Effect of a craniosacral therapy protocol in people with migraine: a randomized controlled trial. Munoz-Gomez E, Ingles M, Aguilar-Rodriguez M, Molla-Casanova S, Sempere-Rubio N, Serra-Ano P, Espi-Lopez G. Journal of Clinical Medicine. 2022 Jan 30;11(3):759. doi: 10.3390/jcm11030759. PMID: 35160211
Effects of foam rolling vs. manual therapy in patients with tension-type headache: a randomized pilot study. Espi-Lopez G, Ingles M, Carrasco-Fernandez J, Serra-Ano P, Copete-Fajardo L, Gonzalez-Gerez J, Saavedra-Hernandez M, Marques-Sule E. Journal of Clinical Medicine. 2022 Mar 23;11(7):1778. doi: 10.3390/jcm11071778. PMID: 35407385
Fourier analysis of collagen bundle orientation in myocardial infarction scars. Marcos-Garces V, Rios-Navarro C, Gomez-Torres F, Gavara J, de Dios E, Diaz A, Minana G, Chorro F, Bodi V, Ruiz-Sauri A. Histochemistry and Cell Biology. 2022 Nov;158(5):471-483. doi: 10.1007/s00418-022-02132-x. PMID: 35948735
A natural xenogeneic endometrial extracellular matrix hydrogel toward improving current human in vitro models and future in vivo applications. Lopez-Martinez S, Campo H, de Miguel-Gomez L, Faus A, Navarro A, Diaz A, Pellicer A, Ferrero H, Cervello I. Frontiers in Bioengineering and Biotechnology. 2021 Mar 5;9:639688. doi: 10.3389/fbioe.2021.639688. PMID: 33748086Anti-inflammatory properties of diet: role in healthy aging.Stromsnes K, Correas A, Lehmann J, Gambini J, Olaso-Gonzalez G. Biomedicines. 2021 Jul 30;9(8):922. doi: 10.3390/biomedicines9080922. PMID: 34440125
Attitudes towards learning professional ethics in undergraduate physiotherapy students: A STROBE compliant cross-sectional study. Marques-Sule E, Arnal-Gomez A, Cortes-Amador S, de la Torre M, Hernandez D, Aguilar-Rodriguez M. Nurse Education Today. 2021 Mar;98:104771. doi: 10.1016/j.nedt.2021.104771. PMID: 33529858
Bcl-xL as a Modulator of Senescence and Aging. Mas-Bargues C, Borras C, Vina J. International Journal of Molecular Sciences. 2021 Feb 3;22(4):1527. doi: 10.3390/ijms22041527. PMID: 33546395
Bioengineered endometrial hydrogels with growth factors promote tissue regeneration and restore fertility in murine models. Lopez-Martinez S, Rodriguez-Eguren A, de Miguel-Gomez L, Frances-Herrero E, Faus A, Diaz A, Pellicer A, Ferrero H, Cervello I. Acta Biomaterialia. 2021 Nov;135:113-125. doi: 10.1016/j.actbio.2021.08.025. PMID: 34428563
Projects
Title: Papel de BCL-Xl en el envejecimiento saludable y la prevención de la fragilidad
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Cristina Más Bargues
Duration: 2022 – 2023
Total budget: 20.000 €
Title: Combining vitamin E-functionalized CHOcolate with physical exercise to reduce the risK of protein energy malnutrition in pre-dementia AGEd people. ERA-HDHL Call for Joint Transnational Research Proposals on Development of targeted nutrition for prevention of undernutrition for older adults (PREVNUT)
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: José Viña Ribes
Duration: 2021 – 2023
Total budget: 169.098 €
Title: Efecto del tratamiento con vesículas extracelulares de células madre de grasa de ratones jóvenes sobre parámetros de envejecimiento y fragilidad en ratones de edad avanzada
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Consuelo Borrás Blasco
Duration: 2021 – 2024
Total budget: 181.500 €
Title: Estudio de posibles huellas genéticas de envejecimiento saludable en descendientes de centenarios
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Marta Inglés de la Torre
Duration: 2018 – 2019
Total budget: 12.040 €
Title: Obesidad materna y disfunción cognitiva en la descendencia: papel causa-efecto de la microbiota intestinal y prevención dietética temprana
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: Consuelo Borrás Blasco
Duration: 2017 – 2022
Total budget: 143.000 €
Title: GUTMOM: Maternal obesity and cognitive dysfunction in the offspring: cause-effect role of the GUT MicrobiOMe and early dietary prevention
Funding body: European Commission. JPI HDHL
Principal Investigator: Patricia Lozzo
Duration: 2017 – 2020
Total budget: 778.240 €
Title: Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
Funding body: European Commission
Principal Investigator: Erich Gnaiger
Duration: 2016 – 2020
Total budget:
+ Info
Doctoral candidate: Vucetic, Jelena
Director(s): Borrás Blasco, Consuelo; Mirón Mombiela, Rebeca; Marcaida Benito, Goizane
Date of the defense: 18/05/2023
University: University de ValenciaTitle: Study of the role of BCL-XL in healthy aging and frailty prevention
Doctoral candidate: Román Domínguez, Aurora
Director(s): Borrás Blasco, Consuelo; Mas Bargues, Cristina; Viña Ribes, José
Date of the defense: 03/03/2023
University: Universitat de ValènciaTitle: Efecto favorable de la comunicación intercelular a través de vesículas extracelulares derivadas de células madre del tejido adiposo en el envejecimiento.
Doctoral candidate: Sanz Ros, Jorge Manuel
Director(s): Borrás Blasco, Consuelo; Viña Ribes, Jose; Mas Bargues, Cristina
Date of the defense: 16/09/2022
University: Univeridad de Valencia
Title: Estudio comparativo de los efectos del ejercicio físico de baja intensidad, de la estimulación magnética transcraneal y de la terapia con oxígeno hiperbárico en mujeres con fibromialgia. Ensayo clínico aleatorizado
Doctoral candidate: Izquierdo Alventosa, Ruth
Director(s): Inglés de la Torre, Marta; Serra Añó, Pilar; Cortés Amador, Sara
Date of the defense: 14/01/2022
University: Univeridad de Valencia
Title: Transcriptómica en centenarios: un ejemplo de envejecimiento satisfactorio
Doctoral candidate: Dromant Jarque, Mar
Director(s): Inglés De La Torre, Marta; Borrás Blasco, Consuelo; Viña Ribes, José
Date of the defense: 21/12/2021
University: Universitat de València
Title: Eficacia de la terapia manual en pacientes con migraña
Doctoral candidate: Muñoz Gómez, Elena
Director(s): Inglés De La Torre, Marta; Espí López, Gemma Victoria
Date of the defense: 23/04/2021
University: Universitat de València
Title: Efecto de la activación del receptor PPARy/RxR como posible tratamiento de la enfermedad de Alzheimer. Papel de la genisteína
Doctoral candidate: Muñoz Cebriá, José Enrique
Director(s): Viña, José; Borrás, Consuelo; Gambini, Juan
Date of the defense: 01/07/2020
University: Universitat de València
Title: Development of an ultrasound-based muscle texture analysis as a potential imaging biomarker for frailty phenotype
Doctoral candidate: Mirón Mombiela, Rebeca
Director(s): Borrás Blasco, Consuelo; Forner Giner, Juana
Date of the defense: 28/01/2019
University: Universitat de València