Research Group on Exercise, Nutrition and Healthy Lifestyle
Metabolism and Organic Damage Area
Role of nicotinamide riboside (NR) and Urolithin A (UroA) as mitotherapeutics for the reversal of energy collapse associated with agingRole of β-hydroxybutyrate on the loss of muscle mass associated with agingEffect of an intervention with protein and vitamin supplementation in synergy with a multicomponent program of physical exercise in the reversal of frailty
Effect of glucosamine supplementation on physical performance
Evaluation of the neuroprotective effect of ketogenic diets (intermittent fasting and carbohydrate-free diet)
High intensity interval exercise in the prevention and treatment of frailty
Study of the effect of the activation of glucose 6 phosphate dehydrogenase with different intervention strategies in the prevention of frailty
Coordinator
RESEARCHERS
Leading, R4
Recognised/Emerging, R2
Aitor Carretero Martínez
Esther García Domínguez
Fernando Millán Domingo
Gloria Olaso González
First Stage, R1
Abril Gorgori González
Ángela García Correas
Eva Tamayo Torres
Kristine Stromsnes
Silvana Javiera Soto Rodríguez
STAFF
Collaborating Researchers
Remus Iulian Lupu
Nurse
Technicians
Administrative assistant
Publications
Low muscle mass is associated with poorer glycemic control and higher oxidative stress in older patients with type 2 Diabetes. Alabadi B, Civera M, De la Rosa A, Martinez-Hervas S, Gomez-Cabrera M, Real J. Nutrients. 2023 Jul 17;15(14):3167. doi: 10.3390/nu15143167. PMID: 37513585Oxidative stress, atherogenic dyslipidemia, and cardiovascular risk. Vekic J, Stromsnes K, Mazzalai S, Zeljkovic A, Rizzo M, Gambini J. Biomedicines. 2023 Oct 26;11(11):2897. doi: 10.3390/biomedicines11112897. PMID: 38001900
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models. Costa-Machado L, Garcia-Dominguez E, McIntyre R, Lopez-Aceituno J, Ballesteros-Gonzalez A, Tapia-Gonzalez A, Fabregat-Safont D, Eisenberg T, Gomez J, Plaza A, Sierra-Ramirez A, Perez M, Villanueva-Bermejo D, Fornari T, Loza M, Herradon G, Hofer S, Magnes C, Madeo F, Duerr J, Pozo O, Galindo M, Del Pino I, Houtkooper R, Megias D, Vina J, Gomez-Cabrera M, Fernandez-Marcos P. Nature Communications. 2023 May 15;14(1):2779. doi: 10.1038/s41467-023-38410-y. PMID: 37188705
Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice. Rodriguez-Ramiro I, Pastor-Fernández A, López-Aceituno JL, Garcia-Dominguez E, Sierra-Ramirez A, Valverde AM, Martinez-Pastor B, Efeyan A, Gomez-Cabrera MC, Viña J, Fernandez-Marcos PJ. Free Radical Biology & Medicine. 2023 Nov 29:210:448-461. doi: 10.1016/j.freeradbiomed.2023.11.019. PMID: 38036067
Pomegranate extract administration reverses loss of motor coordination and prevents oxidative stress in cerebellum of aging mice. Verdú D, Valls A, Díaz A, Carretero A, Dromant M, Kuligowski J, Serna E, Viña J. Antioxidants. 2023 Nov 11;12(11):1991. doi: 10.3390/antiox12111991. PMID: 38001844
Allopurinol blocks aortic aneurysm in a mouse model of Marfan syndrome via reducing aortic oxidative stress. Rodriguez-Rovira I, Arce C, De Rycke K, Perez B, Carretero A, Arbones M, Teixido-Tura G, Gomez-Cabrera M, Campuzano V, Jimenez-Altayo F, Egea G. Free Radical Biology & Medicine. 2022 Nov 5;193(Pt 2):538-550. doi: 10.1016/j.freeradbiomed.2022.11.00. PMID: 36347404Exercise training as a modulator of epigenetic events in prostate tumors. Dufresne S, Gueritat J, Wong CP, Isanejad A, Ho E, Serna E, Gomez-Cabrera MC, Rebillard A. Prostate Cancer and Prostatic Diseases. 2022 Mar;25(1):119-122. doi: 10.1038/s41391-021-00380-x. PMID: 34007020
Glucosamine supplementation improves physical performance in trained mice. De la Rosa A, Olaso-Gonzalez G, Garcia-Dominguez E, Mastaloudis A, Hester S, Wood S, Gomez-Cabrera M, Vina J. Medicine and Science in Sports and Exercise. 2022 Mar 1;54(3):466-474. doi: 10.1249/MSS.0000000000002821. PMID: 34711707
Glucose 6-P dehydrogenase-an antioxidant enzyme with regulatory functions in skeletal muscle during exercise. Garcia-Dominguez E, Carretero A, Vina-Almunia A, Domenech-Fernandez J, Olaso-Gonzalez G, Vina J, Gomez-Cabrera MC. Cells. 2022 Sep 28;11(19):3041. doi: 10.3390/cells11193041. PMID: 36231003
Impact of supplementation with vitamins B6, B12, and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: a systematic review. Olaso-Gonzalez G, Inzitari M, Bellelli G, Morandi A, Barcons N, Vina J. IUBMB Life. 2022 Jan;74(1):74-84. doi: 10.1002/iub.2507. PMID: 34058062
A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts. Gomez-Cabrero D, Walter S, Abugessaisa I, Minambres-Herraiz R, Palomares L, Butcher L, Erusalimsky J, Garcia-Garcia F, Carnicero J, Hardman T, Mischak H, Zurbig P, Hackl M, Grillari J, Fiorillo E, Cucca F, Cesari M, Carrie I, Colpo M, Bandinelli S, Feart C, Peres K, Dartigues J, Helmer C, Vina J, Olaso G, Garcia-Palmero I, Martinez J, Jansen-Durr P, Grune T, Weber D, Lippi G, Bonaguri C, Sinclair A, Tegner J, Rodriguez-Manas L. GeroScience. 2021 Jun;43(3):1317-1329. doi: 10.1007/s11357-021-00334-0. PMID: 33599920Activation of the constitutive androstane receptor inhibits leukocyte adhesiveness to dysfunctional endothelium. Lopez-Riera M, Ortega R, Hueso L, Montesinos MC, Gomez-Cabrera MC, Sanz MJ, Real JT, Piqueras L. International Journal of Molecular Sciences. 2021 Aug 27;22(17):9267. doi: 10.3390/ijms22179267. PMID: 34502180
Anti-inflammatory properties of diet: role in healthy aging.Stromsnes K, Correas A, Lehmann J, Gambini J, Olaso-Gonzalez G. Biomedicines. 2021 Jul 30;9(8):922. doi: 10.3390/biomedicines9080922. PMID: 34440125
Exploring potential benefits of accumulated multicomponent-training in non-active older adults: from physical fitness to mental health. Monteagudo P, Cordellat A, Roldan A, Gomez-Cabrera M, Pesce C, Blasco-Lafarga C. International Journal of Environmental Research and Public Health. 2021 Sep 13;18(18):9645. doi: 10.3390/ijerph18189645. PMID: 34574570
Frailty is associated with oxidative stress in older patients with Type 2 Diabetes. Alabadi B, Civera M, De la Rosa A, Martinez-Hervas S, Gomez-Cabrera MC, Real JT. Nutrients. 2021 Nov 9;13(11):3983. doi: 10.3390/nu13113983. PMID: 34836238
Projects
Title: Redes de Investigación en ciencias del deporte: EXERNET. Red de ejercicio físico y salud
Funding body: Ministerio de Cultura y Deportes
Principal Investigator: José Antonio Casajús
Duration: 2021 – 2022
Total budget: 8.000 €
Title: Diferencias de fragilidad entre generos: Evaluación de biomarcadores y estrategias de intervención
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: José Viña Ribes
Duration: 2020 – 2023
Total budget: 189.391 €
Title: Ejercicio físico personalizado como intervención para revertir la discapacidad en adultos mayores que viven en residencias (RESIFIT)
Funding body: Fundación General del Consejo Superior de Investigaciones Científicas (FGCSIC)
Principal Investigator: Mª Carmen Gómez Cabrera
Duration: 2020 – 2021
Total budget: 24.000 €
Title: Nuevas intervenciones terapéuticas multidominio para retrasar la fragilidad y la discapacidad. Identificación de mecanismos moleculares con relevancia traslacional (Mitofrail)
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: José Viña Ribes, Mª Carmen Gómez Cabrera
Duration: 2020 – 2023
Total budget: 270.000 €
Title: Scaling-up of and evidence-based intervention programme in older people with Diabetes and Frailty in LatinAmerica
Funding body: European Commission
Principal Investigator: José Viña Ribes
Duration: 2019 – 2024
Total budget: 273.720 €
+ Info
Starting year: 2014
Researchers: García Giménez, José Luis
Web: http://www.epidisease.com/
Doctoral candidate: García Domínguez, Esther
Director(s): Viña Ribes, José; Gómez Cabrera, Mari Carmen; Blasco Lafarga, Cristina
Date of the defense: 01/01/2023
University: University de ValenciaTitle: Intervención con ejercicio físico multicomponente sobre el adulto mayor frágil en la vida real (Real Life Intervention)
Doctoral candidate: Millán Domingo, Fernando
Director(s): Viña Ribes, José; Gómez Cabrera, María Carmen; Tarazona Santabalbina, Francisco José
Date of the defense: 01/07/2022
University: Universitat de ValènciaTitle: Papel de la xantina oxidasa en la pérdida de masa muscular por inmovilización en humanos. Importancia del protocolo de obtención de biopsias musculares en los estudios de atrofia muscular
Doctoral candidate: Sebastiá Alcàcer, Vicente
Director(s): Gómez Cabrera, Mª Carmen; Viña Ribes, José; Viosca Herrero, Enrique
Date of the defense: 28/06/2022
University: Universitat de València
Title: Impacto del ejercicio físico a largo plazo en la neuroprotección de sujetos de mediana edad: estudio de los mecanismos moleculares involucrados
Doctoral candidate: De La Rosa González, Adrián
Director(s): Gómez Cabrera, M. Carmen; Sanfeliú Pujol, Coral; Viña Ribes, José
Date of the defense: 05/06/2020
University: Universitat de València
Title: Regulation of antioxidant defenses in the prevention of skeletal muscle deconditioning
Doctoral candidate: Arc-Chagnaud, Coralie
Director(s): Viña Ribes, José; Gómez-Cabrera, Carmen; Chopard, Angèle; Brioche, Thomas
Date of the defense: 22/11/2019
University: Universitat de València
Title: Moderate overexpression of glucose-6-phosphate dehydrogenase improves healthspan in mice. Implications in skeletal muscle regeneration
Doctoral candidate: Salvador Pascual, Andrea
Director(s): Viña Ribes, José; Gomez Cabrera, M. Carmen
Date of the defense: 15/07/2019
University: Universitat de València