Research Group on Tissular Biochemistry

Metabolism and Organic Damage Area

To study the influence of age at pregnancy and duration of breastfeeding on risk of breast cancer, and specifically, the role of calpain-2 as a regulatory node

To study the role of calpains 1, 2 and 3 as key mediators of hormones and Ca2+ metabolism in osteoblast differentiation and platelet abnormalities in LGMD patients

To study the mechanisms that control respiratory homeostasis, as well as the dysregulation of molecular and cellular pathways in respiratory pathological processes, such as vitamin A deficiency, allergic inflammation, or pulmonary fibrosis

Coordinator
Dr. Juan R. Viña Ribes
juan.r.vina@uv.es

RESEARCHERS
Leading, R4

Juan R. Viña Ribes    
Elena Ruiz García-Trevijano
Teresa Barber Ballester

Established, R3

Luis Torres Asensi
Rosa Zaragozá Colom

Recognised/Emerging, R2

Elena Ortiz Zapater

First Stage, R1
STAFF
Collaborating Researchers

Sara Puebla Planas

Nurse
Technicians
Administrative assistant
Publications
Calpains, the proteases of two faces controlling the epithelial homeostasis in mammary gland. García-Trevijano E, Ortiz-Zapater E, Gimeno A, Viña J, Zaragozá R. Frontiers in Cell and Developmental Biology. 2023 Sep 19:11:1249317. doi: 10.3389/fcell.2023.1249317. PMID: 37795261

Sphingosine-1-phosphate induces airway smooth muscle hyperresponsiveness and proliferation. Maguire T, Yung S, Ortiz-Zapater E, Kayode O, Till S, Corrigan C, Siew L, Knock G, Woszczek G. Journal of Allergy and Clinical Immunology. 2023 Nov;152(5):1131-1140.e6. doi: 10.1016/j.jaci.2023.05.028. PMID: 37474025

The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma. Rynne J, Ortiz-Zapater E, Bagley D, Zanin O, Doherty G, Kanabar V, Ward J, Jackson D, Parsons M, Rosenblatt J, Adcock I, Martinez-Nunez R. Frontiers in Cell and Developmental Biology. 2023 Oct 19:11:1241008. doi: 10.3389/fcell.2023.1241008. PMID: 37928904

The role of aryl hydrocarbon receptor in the endothelium: a systematic review. Guerra-Ojeda S, Suarez A, Valls A, Verdu D, Pereda J, Ortiz-Zapater E, Carretero J, Mauricio M, Serna E. International Journal of Molecular Sciences. 2023 Aug 31;24(17):13537. doi: 10.3390/ijms241713537. PMID: 37686342

CAR co-operates with integrins to promote lung cancer cell adhesion and invasion. Owczarek C, Ortiz-Zapater E, Kim J, Papaevangelou E, Santis G, Parsons M. Frontiers in Oncology. 2022 Feb 14;12:829313. doi: 10.3389/fonc.2022.829313. PMID: 35252000

Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation. Ortiz-Zapater E, Bagley D, Hernandez V, Roberts L, Maguire T, Voss F, Mertins P, Kirchner M, Peset-Martin I, Woszczek G, Rosenblatt J, Gotthardt M, Santis G, Parsons M. Nature Communications. 2022 Oct 27;13(1):6407. doi: 10.1038/s41467-022-33882-w. PMID: 36302767

Identification of circulating miRNAs differentially expressed in patients with Limb-girdle, Duchenne or facioscapulohumeral muscular dystrophies. Garcia-Gimenez JL, Garcia-Trevijano ER, Aviles-Alia AI, Ibanez-Cabellos JS, Bovea-Marco M, Bas T, Pallardo FV, Vina JR, Zaragoza R. Orphanet Journal of Rare Diseases. 2022 Dec 27;17(1):450. doi: 10.1186/s13023-022-02603-3. PMID: 36575500

Lung fibrosis and fibrosis in the lungs: is it all about myofibroblasts?. Ortiz-Zapater E, Signes-Costa J, Montero P, Roger I. Biomedicines. 2022 Jun 15;10(6):1423. doi: 10.3390/biomedicines10061423. PMID: 35740444

Cleavage and activation of LIM kinase 1 as a novel mechanism for calpain 2-mediated regulation of nuclear dynamics. Rodriguez-Fernandez L, Company S, Zaragoza R, Vina J, Garcia-Trevijano E. Scientific Reports. 2021 Aug 11;11(1):16339. doi: 10.1038/s41598-021-95797-8. PMID: 34381117

Editorial: organization and functional properties of the blood-brain Barrier. Peterson DR, Hawkins RA, Vina JR. Frontiers in Physiology. 2021 Dec 2;12:796030. doi: 10.3389/fphys.2021.796030. PMID: 34925076

Epigenetic Mechanisms Are Involved in the Oncogenic Properties of ZNF518B in Colorectal Cancer. Gimeno-Valiente F, Riffo-Campos A, Torres L, Tarazona N, Gambardella V, Cervantes A, Lopez-Rodas G, Franco L, Castillo J. Cancers. 2021 Mar 21;13(6):1433. doi: 10.3390/cancers13061433. PMID: 33801071

Projects
Reference: PID2023-149201OB-I00
Title: Proyectos de Generación de conocimiento, AES2023 Entidad
Funding body: Ministerio de Ciencia, Innovación y Universidades
>Principal Investigator: Elena Ortiz-Zapater
Duration: 2024 – 2026
Total budget: 137.500 €
Reference: CIPROM/2021/051
Title: Subvenciones concedidas del Programa Prometeo para grupos de investigación de excelencia
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Elena Ruiz García-Trevijano, Juan Viña Ribes
Duration: 2022 – 2025
Total budget: 240.238 €
Reference: OTR-2019-19499INVES
Title: Molecular mechanisms in the development of scoliosis in limb-girdle muscular dystrophies
Funding body: Fundación Ramón Areces
Principal Investigator: Juan Viña Ribes
Duration: 2019 – 2021
Total budget: 121.176 €
Reference: PROMETEO/2018/167
Title: Estudios tridimensionales de ductos mamarios para determinar el papel de las calpaínas en la remodelación del tejido mamario. Implicaciones biomédicas
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Juan Viña Ribes
Duration: 2018 – 2021
Total budget: 201.920 €
+ Info
Title: Subcellular distribution of calpain-1 and calpain-2 as a key event for calpain-mediated functions in physiological and neoplastic mammary models
Doctoral candidate: Rodríguez Fernández, Lucía
Director(s): Viña Ribes, Juan; Zaragozá Colom, Rosa; Ruiz García-Trevijano, Elena
Date of the defense: 29/03/2019
University: Universitat de València