Group on Translational Research in Ischemic Heart Disease
Cardiovascular Area
From our research experience from the last years in the clinical and experimental field related to ischemic cardiopathy, our current goal is to focus into a translational approach
In 2021 we continued elucidating the abnormalities in the coronary circulation after a myocardial infarction by using a swine model. Moreover, we have also started to evaluate in vitro the role of endothelial injury after coronary reperfusion and the implication of angiogenesis in the recovery of the microvasculature after a myocardial infarction in animal models and in patients
We have also developed new tools to study patients with ST-segment elevation myocardial infarction using cardiac magnetic resonance imaging
Coordinator
STAFF
Collaborating Researchers
Joaquim Cànoves FemeniaPaolo Racugno
Nurse
Francisca Esteve ClaramuntMaría Regina Blanco del Burgo
Technicians
Andrea Arroyo ÁlvarezCarles Muñoz AlfonsoGuillermo Barreres MartínDaznia Loiret Bompart BerroteranIlza Victoria Freitas DurksTamara Molina García
Administrative assistant
Javier Damià Escrig
Publications
Solitary fibrous tumor: can the new Huang risk stratification system for orbital tumors improve prognostic accuracy in other tumor locations?. Medina-Ceballos E, Machado I, Giner F, Bujeda A, Navarro S, Ferrandez A, Lavernia J, Ruiz-Sauri A, Llombart-Bosch A. Pathology, Research and Practice. 2024 Feb:254:155143. doi: 10.1016/j.prp.2024.155143. PMID: 38301364
ß-Blocker withdrawal and functional capacity improvement in patients with heart failure with preserved ejection fraction. Palau P, de la Espriella R, Seller J, Santas E, Dominguez E, Bodi V, Sanchis J, Núñez E, Bayés-Genis A, Bertomeu-González V, Meyer M, Núñez J. JAMA Cardiology. 2024 Feb 7:e235500. doi: 10.1001/jamacardio.2023.5500. PMID: 38324280
Cardiac magnetic resonance outperforms echocardiography to predict subsequent implantable cardioverter defibrillator therapies in ST-segment elevation myocardial infarction patients. Marcos-Garces V, Perez N, Gavara J, Lopez-Lereu M, Monmeneu J, Rios-Navarro C, de Dios E, Merenciano-Gonzalez H, Gabaldon-Perez A, Ferrero-de-Loma-Osorio A, Martinez-Brotons A, Bondanza L, Sanchez-Gomez J, Albiach C, Nunez J, Bayes-Genis A, Chorro F, Ruiz-Granell R, Bodi V. Frontiers in Cardiovascular Medicine. 2023 Feb 3;10:991307. doi: 10.3389/fcvm.2023.991307. PMID: 36818338
Changes in the extracellular matrix at microvascular obstruction area after reperfused myocardial infarction: A morphometric study. Blazquez-Bujeda A, Ortega M, de Dios E, Gavara J, Perez-Sole N, Molina-Garcia T, Marcos-Garces V, Diaz A, Chorro F, Rios-Navarro C, Bodi V, Ruiz-Sauri A. Annals of Anatomy-Anatomischer Anzeiger. 2023 Jul 26;250:152138. doi: 10.1016/j.aanat.2023.152138. PMID: 37506775
Chronotropic index and long-term outcomes in heart failure with preserved ejection fraction. Palau P, Dominguez E, Seller J, Sastre C, Sanchis J, Lopez L, Bodi V, Llacer P, Minana G, Espriella R, Bayes-Genis A, Nunez J. Revista Espanola de Cardiologia (English ed.). 2023 Jul;76(7):511-518. doi: 10.1016/j.rec.2022.08.003. PMID: 36038124
Clinical benefit of bempedoic acid in randomized clinical trials. Cordero A, Olmo R, Santos-Gallego C, Fácila L, Bonanad C, Castellano J, Rodriguez-Mañero M, Seijas-Amigo J, González-Juanatey J, Badimon J. American Journal of Cardiology. 2023 Oct 15:205:321-324. doi: 10.1016/j.amjcard.2023.07.145. PMID: 37633067
Applicability of echocardiographic strict negative criteria for suspected infective endocarditis. Marcos-Garces V, Gabaldon-Perez A, Merenciano-Gonzalez H, Soler M, Lorenzo-Hernandez M, Nunez-Marin G, de la Espriella R, Bonanad C, Nunez J, Chorro FJ, Bodi V, Santas E. American Journal of Cardiology. 2022 Jan 1;162:156-162. doi: 10.1016/j.amjcard.2021.09.012. PMID: 34728063
Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure. de la Espriella R, Amiguet M, Minana G, Rodriguez JC, Moyano P, Segarra D, Fernandez J, Santas E, Nunez G, Lorenzo M, Bonanad C, Alania E, Valle A, Sanchis J, Bodi V, Gorriz JL, Navarro J, Codina P, Voors AA, Bayes-Genis A, Nunez J. European Journal of Heart Failure. 2022 Nov;24(11):2108-2117. doi: 10.1002/ejhf.2651. PMID: 36054502
Carbohydrate antigen 125 and risk of heart failure readmissions in patients with heart failure and preserved ejection fraction. Minana G, de la Espriella R, Palau P, Llacer P, Nunez E, Santas E, Valero E, Lorenzo M, Nunez G, Bodi V, Heredia R, Sanchis J, Bayes-Genis A, Chorro F, Nunez J. Scientific Reports. 2022 Jan 25;12(1):1344. doi: 10.1038/s41598-022-05328-2. PMID: 35079082
Cardiovascular prevention in elderly patients. Bonanad C, Fernandez-Olmo R, Garcia-Blas S, Alarcon J, Diez-Villanueva P, Mansilla C, Garcia-Pardo H, Toledo P, Ayesta A, Pereira E, Carol A, Castro-Conde A, de Pablo-Zarzoso C, Martinez-Selles M, Arrarte V, Campuzano R, Ariza-Sole A. Journal of Geriatric Cardiology. 2022 May 28;19(5):377-392. doi: 10.11909/j.issn.1671-5411.2022.05.004. PMID: 35722032
Anomalous right coronary artery from the left sinus with interarterial course. Marcos Garcés V, Lorenzo Hernández M, Martínez Más M, Parrilla Muñoz C, Pernias Escrig V, Bodí Peris V. Coronary Artery Disease. 2021 Aug 1;32(5):475-477. doi: 10.1097/MCA.0000000000000941. PMID: 32804784
Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review. Nunez J, de la Espriella R, Minana G, Santas E, Llacer P, Nunez E, Palau P, Bodi V, Chorro F, Sanchis J, Lupon J, Bayes-Genis A. European Journal of Heart Failure. 2021 Sep;23(9):1445-1457. doi: 10.1002/ejhf.2295. PMID: 34241936
Atrial fibrillation in patients with COVID-19. Usefulness of the CHA2DS2-VASc score: an analysis of the international HOPE COVID-19 registry. Uribarri A, Nunez-Gil I, Aparisi A, Arroyo-Espliguero R, Eid C, Romero R, Becerra-Munoz V, Feltes G, Molina M, Garcia-Aguado M, Cerrato E, Capel-Astrua T, Alfonso-Rodriguez E, Castro-Mejia A, Raposeiras-Roubin S, Espejo C, Perez-Sole N, Bardaji A, Marin F, Fabregat-Andres O, D’ascenzo F, Santoro F, Akin I, Estrada V, Fernandez-Ortiz A, Macaya C, en representacion de los investigadores del HOPE COVID-19. Revista Espanola de Cardiologia. 2021 Jul;74(7):608-615. doi: 10.1016/j.recesp.2020.12.014. PMID: 33678938
Automatic left ventricle volume calculation with explainability through a deep learning weak-supervision methodology. Perez-Pelegri M, Monmeneu J, Lopez-Lereu M, Perez-Pelegri L, Maceira A, Bodi V, Moratal D. Computer Methods and Programs in Biomedicine. 2021 Sep;208:106275. doi: 10.1016/j.cmpb.2021.106275. PMID: 34274609
Projects
Title: Resonancia magnética cardíaca de estrés con vasodilatadores para predecir la mortalidad a largo plazo en un amplio registro retrospectivo de pacientes con cardiopatía isquémica conocida o sospechada
Funding body: Sociedad Española de Cardiología
Principal Investigator: Vicent Bodí Peris
Duration: 2021 – 2022
Total budget: 15.000 €
Title: A multidisciplinary study to advance in the understanding of the basic mechanisms and clinical implications of microvascular obstruction after acute myocardial infarction. Exploration of novel diagnostic and therapeutic opportunities
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Vicente Bodí Peris, Amparo Ruiz Saurí
Duration: 2021 – 2024
Total budget: 435.929 €
Title: Resolución de la obstrucción microvascular tras un infartodemiocardio: evaluación de las consecuencias estructurales y clínicas y búsqueda de nuevas opciones terapéuticas
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Vicent Bodí Peris, Clara Bonanad Lozano
Duration: 2021 – 2023
Total budget: 129.470 €
Title: Estudio multidisciplinar de la dinámica, mecanismos básicos, diagnóstico y exploración de nuevas oportunidades terapéuticas en la obstrucción microvascular tras infarto agudo de miocardio
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Clara Bonanad Lozano
Duration: 2018 – 2019
Total budget: 15.000 €
Title: Estudio multidisciplinar de la obstrucción microvascular y su reparación tras un infarto agudo demiocardio: de la arteria coronaria a la microcirculación. Foco en el factor VEGF-A165b
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Vicente Bodí Peris
Duration: 2018 – 2020
Total budget: 99.220 €
Title: A multidisciplinary Project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Vicente Bodí Peris
Duration: 2016 – 2019
Total budget: 589.050 €
+ Info
Doctoral candidate: Ríos Navarro, César
Director(s): Bodí Peris, Vicent; Ruiz Saurí, Amparo
Date of the defense: 01/07/2022
University: Universitat de València
Title: Patogenicidad de la infección invasiva por Candida Auris: virulencia en un modelo de infección in vivo y factores de riesgo de Candidemia
Doctoral candidate: García Bustos, Víctor
Director(s): Pemán García, Javier; Ruiz Saurí, Amparo
Date of the defense: 09/05/2022
University: Universitat de València
Title: Avances en estratificación pronóstica mediante resonancia magnética cardíaca en pacientes con síndrome coronario crónico
Doctoral candidate: Marcos Garcés, Víctor
Director(s): Bodí Peris Vicent , Ruiz Saurí Amparo
Date of the defense: 18/02/2022
University: Universitat de València
Title: Comparación de las diferentes técnicas de cementación de la bandeja tibial en las prótesis de rodilla
Doctoral candidate: Rodríguez Collell, Juan Ramón
Director(s): Valverde Navarro, Alfonso A; Mifsut Miedes, Damián; Ruiz Saurí, Amparo
Date of the defense: 11/09/2020
University: Universitat de València
Title: Estudio de la deformidad del tejido cardiaco (strain) tras un infarto de miocardio con elevación del segmento ST mediante la técnica de resonancia magnética tissue tracking: dinámica, implicación estructural y valor pronóstico
Doctoral candidate: Gavara Doñate, Josep
Director(s): Monmeneu Menadas José Vicente; Bodí Peris Vicente
Date of the defense: 19/06/2020
University: Universitat de València