Cardiometabolic Research Group on Primary Care

Cardiovascular Area
The Research Group on Primary Care was created more than fifteen years ago with the aim of incorporating the perspective of primary care professionals, who are the first ones to establish contact with patients, into health research.
This group, initially focused on cardiometabolic research, has extended the scope of its activity by integrating new lines, such as active aging, liver diseases and pediatric research, and has consolidated research based on Big Data. It has recently opened new lines of work in mental health and genetics.
He addressed issues such as the cardiovascular impact of risk factors (such as smoking, hypertension and diabetes), health care inequalities according to gender, the impact of social determinants, diagnostic and therapeutic inertia, potentially inappropriate prescribing and the stratification of the chronic population according to costs.
He collaborates with other INCLIVA Research Groups like General Medicine, Cardiology, Nephrology and Aging.
Currently, the Group is made up of more than 50 researchers, who are primary care health professionals at the Valencia Clinical-Malvarrosa Health Department.
Dr. Jorge Navarro Pérez
Coordinator
Dr. Jorge Navarro Pérez
jorge.navarro@uv.es; jorgenavper@gmail.com

RESEARCHERS
Leading, R4

Jorge Navarro Pérez    

Established, R3

José Luis Trillo Mata
Álvaro Bonet Pla
Carolina Mir Sánchez
Desamparados Garcés Sánchez

Recognised/Emerging, R2
First Stage, R1
STAFF
Collaborating Researchers

Ester Robles Pastor
Luz Vázquez Canales
Paula Sala Ivars
Celia Poveda Rocamora
Esther Carrión Albert
Mª Dolores Seligra Borrull
Marina Gimeno Gimeno
Tamara Miravalls Pérez
Verónica Lozano Rodríguez
Aaron Piera Torró
Alberto Belenguer Guillot
Alex David Misle Morales
Alexandre Sorribes Ramírez
Carmina Martínez Vernia
Cristina Más Lázaro
Diana Vicente Miralles
Eduardo Rovira Cabrera
Enrique Guinot Martínez
Eugenia Avelino Hidalgo
Idoia Aramburu Aizpiri
Ignacio Ramos Manuel
Irene Marco Moreno
Ismael Ejarque Doménech
Isabel Gabaldón Sánchez
Laura Almudéver Campo
Lucía Navarro Salvador
Mª José Puchades Company
Margarita Giménez Loreiro
María Aóda Andreu Lledó
María Ferrus Domingo
Maria José Garzón Nieto
Marisa Gómez Arnero
Nidia Ruiz Varea
Óscar Pérez Quintana
Pablo Sabater Arnaldos
Pilar Roca Navarro
Ricardo González Espadas
Ruth Uribes Fillol
Sofía Bauer Izquierdo
Svitlana Nikítina Osadcha 
Tomás Sánchez Ruiz
Verónica Audina Márquez
Vibiana Blanco Alvarado
Victoria Gosalbes Soler

Nurse
Technicians
Administrative assistant
Publications
Changes in benign prostatic hyperplasia management in Valencia: a real-world evidence analysis. Navarro-Perez J, Lopez Alcina E, Calabiug Perez J, Brotons Munto F, Martinez A, Vallejo L, Jimenez J. Actas Urologicas Espanolas. 2024 Feb 16:S2173-5786(24)00012-X. doi: 10.1016/j.acuroe.2024.02.005. PMID: 38369289

Implementation of pharmacogenetics in primary care. Ejarque Domenech I, Souviron Rodriguez A, Herrero Cervera M, Llerena A. Atencion Primaria. 2024 Feb 19;56(5):102881. doi: 10.1016/j.aprim.2024.102881. PMID: 38377772

Author Correction: a new risk score to assess atrial fibrillation risk in hypertensive patients (ESCARVAL-RISK Project). Orozco-Beltran D, Quesada JA, Bertomeu-Gonzalez V, Lobos-Bejarano JM, Navarro-Perez J, Gil-Guillen VF, Ortiz LG, Lopez-Pineda A, Castellanos-Rodriguez A, Lopez-Domenech A, Cardona-Llorens AFJ, Carratala-Munuera C. Scientific Reports. 2023 Aug 16;13(1):13297. doi: 10.1038/s41598-023-40306-2. PMID: 37587145

Biomarkers of preclinical ventricular dysfunction in type 2 diabetes mellitus. Bayes-Genis A, Navarro J, Rodriguez-Padial L. Revista Espanola de Cardiologia (english Ed.). 2023 Jan;76(1):4-6. doi: 10.1016/j.rec.2022.06.008. PMID: 35787949

Cardiovascular risk assessment of elevated blood pressure for screening and early detection in children 6 to 9 years of age in the Valencian Community: ANIVA Study. Morales-Suarez-Varela M, Peraita-Costa I, Llopis-Morales A, Perez J. Children. 2023 Dec 14;10(12):1928. doi: 10.3390/children10121928. PMID: 38136130

Claiming to be able to draw the family tree in the Primary Care electronic medical record. Doménech I, Valero C, Fernández I, Rodríguez A. Atencion Primaria. 2023 Dec;55(12):102768. doi: 10.1016/j.aprim.2023.102768. PMID: 37738700

Comparison of GLP-1 Receptor agonists and other glucose-lowering agents on cardiovascular outcomes in individuals with type 2 diabetes and obesity: a spanish real-world population-based study. Palanca A, Javier Ampudia-Blasco F, Miguel Calderon J, Sauri I, Martinez-Hervas S, Luis Trillo J, Redon J, Real J. Diabetes Research and Clinical Practice. 2023 Dec 22:111071. doi: 10.1016/j.diabres.2023.111071. PMID: 38142748

Genetic testing in primary care. Fernandez Torres S, Ejarque Domenech I. Atencion Primaria. 2023 Jun 27;55(8):102695. doi: 10.1016/j.aprim.2023.102695. PMID: 37385051

Lipoprotein(a) and long-term recurrent infarction after an acute myocardial infarction. Miñana G, Cordero A, Fácila L, Company M, Fernández-Cisnal A, Valero E, Carratalá A, Navarro J, Llergo J, Fernández-Olmo R, Castro A, Bodi V, Sanchis J, Núñez J. American Journal of Cardiology. 2023 Oct 18:211:9-16. doi: 10.1016/j.amjcard.2023.10.028. PMID: 37858663

Real-world evaluation of GLP-1 receptor agonist therapy persistence, adherence and therapeutic inertia among obese adults with Type 2 Diabetes. Palanca A, Ampudia Blasco F, Calderon J, Sauri I, Martinez Hervas S, Trillo J, Redon J, Real J. Diabetes Therapy. 2023 Apr;14(4):723-736. doi: 10.1007/s13300-023-01382-9. PMID: 36847952

Safety and immunogenicity of the protein-based PHH-1V compared to BNT162b2 as a heterologous SARS-CoV-2 booster vaccine in adults vaccinated against COVID-19: a multicentre, randomised, double-blind, non-inferiority phase IIb trial. Corominas J, Garriga C, Prenafeta A, Moros A, Canete M, Barreiro A, Gonzalez-Gonzalez L, Madrenas L, Guell I, Clotet B, Izquierdo-Useros N, Raich-Regue D, Gallemi M, Blanco J, Pradenas E, Trinite B, Prado J, Blanch-Lombarte O, Perez-Caballero R, Plana M, Esteban I, Pastor-Quinones C, Nunez-Costa X, Taleb R, McSkimming P, Soriano A, Nava J, Anagua J, Ramos R, Lluch R, Comes A, Romero S, Gomez X, Sans-Pola C, Molto J, Benet S, Bailon L, Arribas J, Borobia A, Parada J, Navarro-Perez J, Forner Giner M, Lucas R, Jimenez M, Compan S, Alvarez-Mon M, Troncoso D, Arana-Arri E, Meijide S, Imaz-Ayo N, Garcia P, de la Villa Martinez S, Fernandez S, Prat T, Torroella E, Ferrer L. Lancet Regional Health. Europe. 2023 May;28:100613. doi: 10.1016/j.lanepe.2023.100613. PMID: 37131861

Value contribution of cenobamate for the treatment of Focal-Onset Seizures (FOS) in patients with drug-resistant epilepsy (DRE) in Spain through reflective Multi-Criteria Decision Analysis (MCDA). Falip M, González F, Martín-Herranz I, Merino-Bohórquez V, Montoya J, Gómez-Serranillos I, Uranga J, Ruiz E, Sancho-López A, Mata J, Vallès J, Alvarez-Barón E, Sabaniego J, Subías-Labazuy S, Gil A. Epilepsy & Behavior. 2023 Aug:145:109350. doi: 10.1016/j.yebeh.2023.109350. PMID: 37480633

Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure. de la Espriella R, Amiguet M, Minana G, Rodriguez JC, Moyano P, Segarra D, Fernandez J, Santas E, Nunez G, Lorenzo M, Bonanad C, Alania E, Valle A, Sanchis J, Bodi V, Gorriz JL, Navarro J, Codina P, Voors AA, Bayes-Genis A, Nunez J. European Journal of Heart Failure. 2022 Nov;24(11):2108-2117. doi: 10.1002/ejhf.2651. PMID: 36054502

Cardiovascular preventive recommendations. PAPPS 2022 thematic updates. Working groups of the PAPPS. Orozco-Beltran D, Brotons Cuixart C, Banegas Banegas J, Gil Guillen V, Cebrian Cuenca A, Martin Rioboo E, Jorda Baldo A, Vicuna J, Navarro Perez J. Atencion Primaria. 2022 Oct;54 Suppl 1(Suppl 1):102444. doi: 10.1016/j.aprim.2022.102444. PMID: 36435583

Characterizing diagnostic inertia in arterial hypertension with a gender perspective in primary care. Pallares Carratala V, Carratala Munuera C, Lopez Pineda A, Quesada J, Gil Guillen V, Orozco Beltran D, Alfonso Sanchez J, Navarro Perez J, Martin Moreno J. Frontiers in Cardiovascular Medicine. 2022 Jun 16;9:874764. doi: 10.3389/fcvm.2022.874764. PMID: 35783866

Frailty and hospitalization burden in patients with chronic heart failure. Mollar A, Bonanad C, Diez-Villanueva P, Segarra D, Civera J, Sastre C, Conesa A, Villaescusa A, Fernández J, Miñana G, Navarro J, Sanchis J, Núñez J. American Journal of Cardiology. 2022 Nov 15;183:48-54. doi: 10.1016/j.amjcard.2022.08.013. PMID: 36153181

Impact of the COVID-19 pandemic on a cancer fast-track programme. Martinez M, Moragon S, Ortega-Morillo B, Monton-Bueno J, Simon S, Rosello S, Insa A, Viala A, Navarro J, Sanmartin A, Fluixa C, Julve A, Soriano D, Buch E, Pena A, Franco J, Martinez-Jabaloyas J, Marco J, Forner M, Cano A, Silvestre A, Teruel A, Bermejo B, Cervantes A, Chirivella Gonzalez I. Cancer Control. 2022 Jan-Dec;29:10732748221131000. doi: 10.1177/10732748221131000. PMID: 36355430

Incidence and impact of atrial fibrillation in heart failure patients: real-world data in a large community. Diaz J, Martinez F, Calderon JM, Fernandez A, Sauri I, Uso R, Trillo JL, Redon J, Forner MJ. ESC Heart Failure. 2022 Dec;9(6):4230-4239. doi: 10.1002/ehf2.14124. PMID: 36111519

Long-term prognostic impact of estimated glomerular filtration rate on admission in patients hospitalized for acute heart failure. de la Espriella R, Navarro J, Mollar A, D’Marco L, Palau P, Minana G, Llacer P, Santas E, Heredia R, Gonzalez M, Gorriz JL, Codina P, Diez J, Bayes-Genis A, Nunez J. Cardiorenal Medicine. 2022;12(4):179-188. doi: 10.1159/000526105. PMID: 36282062

Neutralizing antibodies against SARS-CoV-2 variants of concern elicited by the comirnaty COVID-19 vaccine in nursing home residents. Sánchez-Sendra B, Albert E, Zulaica J, Torres I, Giménez E, Botija P, Beltrán MJ, Rodado C, Geller R, Navarro D. Scientific Reports. 2022 Mar 8;12(1):3788. doi: 10.1038/s41598-022-07849-2. PMID: 35260713

Real world data of anticoagulant treatment in non-valvular atrial fibrillation across renal function status. Calderon J, Martinez F, Fernandez A, Sauri I, Diaz J, Uso R, Trillo J, Redon J, Forner M. Scientific reports. 2022 Apr 12;12(1):6123. doi: 10.1038/s41598-022-10164-5. PMID: 35414001

Real-life performance of a COVID-19 rapid antigen detection test targeting the SARS-CoV-2 nucleoprotein for diagnosis of COVID-19 due to the Omicron variant. de Michelena P, Torres I, Ramos Garcia A, Gozalbes V, Ruiz N, Sanmartin A, Botija P, Poujois S, Huntley D, Albert E, Navarro D. Journal of Infection. 2022 May;84(5):e64-e66. doi: 10.1016/j.jinf.2022.02.022. PMID: 35217106

Real-world data of anticoagulant treatment in non-valvular atrial fibrillation. Calderon J, Martinez F, Diaz J, Fernandez A, Sauri I, Uso R, Trillo J, Vela S, Bea C, Redon J, Forner M. Frontiers In Cardiovascular Medicine. 2022 Jan 21;8:733300. doi: 10.3389/fcvm.2021.733300. PMID: 35127843

Renal histologic findings in necropsies of Type 2 Diabetes Mellitus patients. D’Marco L, Puchades M, Escudero-Saiz V, Gimenez-Civera E, Terradez L, Moscardo A, Carbonell-Asins J, Perez-Bernat E, Torregrosa I, Moncho F, Navarro J, Gorriz J. Journal of Diabetes Research. 2022 Sep 6;2022:3893853. doi: 10.1155/2022/3893853. PMID: 36110834

SARS-CoV-2 Omicron BA.1 variant breakthrough infections in nursing home residents after an homologous third dose of the Comirnaty (R) COVID-19 vaccine: looking for correlates of protection. Torres I, Gimenez E, Albert E, Zulaica J, Alvarez-Rodriguez B, Burgos J, Peiro S, Limon R, Vanaclocha H, Rodado C, Botija P, Sifre A, Tur B, Lozano R, Orosa I, Vicente-Ruiz M, Carrion R, Clari M, Sanchez-Paya J, Diez-Domingo J, Comas I, Gonzalez-Candelas F, Geller R, Navarro D. Journal of Medical Virology. 2022 Sep;94(9):4216-4223. doi: 10.1002/jmv.27867. PMID: 35585782

The contribution of fenfluramine to the treatment of Dravet syndrome in Spain through multi-criteria decision analysis. Gil-Nagel A, Falip M, Sanchez-Carpintero R, Abad-Sazatornil M, Poveda J, Aibar J, Cardenal-Munoz E, Aras L, Sanchez R, Sancho-Lopez A, Trillo-Mata J, Torrejon M, Gil A. Epilepsy & Behavior. 2022 Jul;132:108711. doi: 10.1016/j.yebeh.2022.108711. PMID: 35588562

Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease. Gorriz J, Arroyo D, D’Marco L, Torra R, Tomas P, Puchades M, Panizo N, Pantoja J, Montomoli M, Llisterri J, Pallares-Carratala V, Valdivielso J. BMC nephrology. 2021 Mar 25;22(1):110. doi: 10.1186/s12882-021-02313-1. PMID: 33765945

Checklist for patients with type 2 diabetes mellitus for remote consultation. Angullo-Martinez E, Carretero-Anibarro E, Barrancos I, Claramunt X, Beltran D, Baile J, Loiola P, Grp Trabajo Diabet SemFyC. Atencion Primaria. 2021 Apr;53(4):101983. doi: 10.1016/j.aprim.2021.101983. PMID: 33743202

Cost of Type 2 diabetes patients with chronic kidney disease based on real-world data: an observational population-based study in Spain. Uso-Talamantes R, Gonzalez-de-Julian S, Diaz-Carnicero J, Sauri-Ferrer I, Trillo-Mata J, Carrasco-Perez M, Navarro-Perez J, Gorriz J, Vivas-Consuelo D, Redon J. International Journal of Environmental Research and Public Health. 2021 Sep 18;18(18):9853. doi: 10.3390/ijerph18189853. PMID: 34574782

Determining the burden of infectious diseases caused by carbapenem-resistant gram-negative bacteria in Spain. Canton R, Huarte R, Morata L, Trillo-Mata J, Munoz R, Gonzalez J, Tort M, Badia X. Enfermedades Infecciosas y Microbiologia Clinica. 2021 Apr;39(4):179-183. doi: 10.1016/j.eimc.2020.04.009. PMID: 32576392

Disorders in bone-mineral parameters and the risk of death in persons with chronic kidney disease stages 4 and 5: the PECERA study. Molina P, Molina M, Pallardo L, Torralba J, Escudero V, Alvarez L, Peris A, Sanchez-Perez P, Gonzalez-Rico M, Puchades M, Fernandez-Najera J, Gimenez-Civera E, D’Marco L, Carrero J, Gorriz J. Journal Of Nephrology. 2021 Aug;34(4):1189-1199. doi: 10.1007/s40620-020-00916-9. PMID: 33394344

Gender differences in the diagnosis of dyslipidemia: ESCARVAL-GENERO. Soriano-Maldonado C, Lopez-Pineda A, Orozco-Beltran D, Quesada JA, Alfonso-Sanchez JL, Pallares-Carratala V, Navarro-Perez J, Gil-Guillen VF, Martin-Moreno JM, Carratala-Munuera C. International Journal of Environmental Research and Public Health. 2021 Nov 25;18(23):12419. doi: 10.3390/ijerph182312419. PMID: 34886144

Gender inequalities in diagnostic inertia around the three most prevalent cardiovascular risk studies: protocol for a population-based cohort study. Carratala-Munuera C, Lopez-Pineda A, Orozco-Beltran D, Quesada J, Alfonso-Sanchez J, Pallares-Carratala V, Soriano-Maldonado C, Navarro-Perez J, Gil-Guillen V, Martin-Moreno J. International Journal of Environmental Research and Public Health. 2021 Apr 12;18(8):4054. doi: 10.3390/ijerph18084054. PMID: 33921396

Hospital admissions trends for severe hypoglycemia in diabetes patients in Spain, 2005 to 2015. Domingo O, Alberto G, Ana Maria C, Jorge N, Vicente G, Quesada-Rico Jose A, Pomares-Gomez Francisco J, Adriana L, Concepcion C. Diabetes Research and Clinical Practice. 2021 Jan;171:108565. doi: 10.1016/j.diabres.2020.108565. PMID: 33242511

Primary care at home in the framework of the COVID-19 pandemic. Cortes J, Sanchez C, Pajares P. Atencion Primaria. 2021 Mar;53(3):101963. doi: 10.1016/j.aprim.2020.12.004. PMID: 33517112

Renal function and attributable risk of death and cardiovascular hospitalization in participants with diabetes from a registry-based cohort. Ruiz-Quintero M, Redón Mas J, Tellez-Plaza M, Cebrian-Cuenca A, Navarro Perez J, Menendez E, Perez-Navarro A, Fernandez-Gimenez A, Lopez-Pineda A, Quesada J, Pallares-Carratala V, Gil-Guillen V, Martín Moreno J, Bleda-Cano J, Carrascosa S, Carratala-Munuera C. Primary Care Diabetes. 2021 Feb;15(1):88-94. doi: 10.1016/j.pcd.2020.06.004. PMID: 32646765

Ten-year assessment of a cancer fast-track programme to connect primary care with oncology: reducing time from initial symptoms to diagnosis and treatment initiation. Martinez MT, Monton-Bueno J, Simon S, Ortega B, Moragon S, Rosello S, Insa A, Navarro J, Sanmartin A, Julve A, Buch E, Pena A, Franco J, Martinez-Jabaloyas J, Marco J, Forner MJ, Cano A, Silvestre A, Teruel A, Lluch A, Cervantes A, Chirivella Gonzalez I. ESMO open. 2021 May 11;6(3):100148. doi: 10.1016/j.esmoop.2021.100148. PMID: 33989988

Therapeutic inertia in patients with type 2 diabetes treated with non-insulin agents. Ampudia-Blasco F, Palanca A, Trillo J, Navarro J, Real J. Journal of diabetes and its complications. 2021 Mar;35(3):107828. doi: 10.1016/j.jdiacomp.2020.107828. PMID: 33436143

Projects
Reference: PI21/01417
Title: Cribado sistemático de insuficiencia cardíaca en pacientes con diabetes mellitus tipo 2. Estudio piloto
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Enrique Santas Olmeda, Jorge Navarro Pérez
Duration: 2022 – 2024
Total budget: 90.871 €
Reference: PI16/02130
Title: Impacto de la auto-medición y el auto-ajuste de la medicación antihipertensiva en el control de la hipertensión arterial. Un ensayo clínico pragmático: estudio ADAMPA
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Jorge Navarro Pérez
Duration: 2017 – 2021
Total budget: 86.515 €
+ Info
Title: Calidad de la farmacoterapia antidiabética en el departamento de salud valencia clínico malvarrosa en 2015-2019 con datos de vida real
Doctoral candidate: Ruiz Domingo, Pablo
Director(s): Cortijo Gimeno, Julio; Trillo Mata, José Luis; Usó Talamantes, Ruth
Date of the defense: 10/07/2023
University: University de Valencia

Title: Análisis de las prescripciones potencialmente inadecuadas según los criterios STOPP/START en los residentes de los centros sociosanitarios del Departamento de Salud Clínico-Malvarrosa de Valencia desde 2016 hasta 2018
Doctoral candidate: Díaz Planelles, Isabel
Director(s): Navarro Pérez, Jorge; Trillo Mata, José Luis
Date of the defense: 30/03/2022
University: Universitat de València

Title: Análisis de los determinantes socioeconómicos y de la morbilidad del Departamento de Salud Valencia Clínico-Malvarrosa. Desarrollo de un índice de privación poblacional integrado
Doctoral candidate: Pilar Botija Yagüe
Director(s): Usó Talamantes, Ruth; Navarro Pérez, Jorge; Botija Yagüe, Mª de las Mercedes
Date of the defense: 30/11/2021
University: Universitat de València

Title: Efectividad de una intervención de automanejo de la hipertensión arterial en la mejora de la inercia terapéutica y la adherencia a los medicamentos antihipertensivos. Ensayo clínico pragmático ADAMPA
Doctoral candidate: Marco Moreno, Irene
Director(s): Sanfélix, Gabriel; Peiró Moreno, Salvador; San Félix Genovés, Jose
Date of the defense: 28/04/2021
University: Universitat de València

Title: Análisis epidemiológico de la fibromialgia en la Comunidad Valenciana
Doctoral candidate: Cabo Meseguer, Asensio Francisco
Director(s): Trillo Mata, Jose Luis; Cerdá Olmedo, Germán
Date of the defense: 25/02/2019
University: University Católica de Valencia San Vicente Mártir